LGALS3 — 42 ClinVar variants
All ClinVar germline LGALS3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
4 Benign · 4 Likely benign · 34 Uncertain significance
Full LGALS3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGALS3 p.Ala212Val Uncertain significance Single submitter
- LGALS3 p.Ala44Val Uncertain significance Single submitter
- LGALS3 p.Arg162Cys Uncertain significance Single submitter
- LGALS3 p.Arg162His Uncertain significance Single submitter
- LGALS3 p.Arg224Gln Uncertain significance Single submitter
- LGALS3 p.Asn141Ser Uncertain significance Single submitter
- LGALS3 p.Asn153Lys Uncertain significance Single submitter
- LGALS3 p.Gln187Arg Uncertain significance Single submitter
- LGALS3 p.Glu193Gln Uncertain significance Single submitter
- LGALS3 p.Gly85Val Uncertain significance Single submitter
- LGALS3 p.His8Arg Uncertain significance Single submitter
- LGALS3 p.Leu135Val Uncertain significance Single submitter
- LGALS3 p.Leu234Arg Uncertain significance Single submitter
- LGALS3 p.Phe198Ser Uncertain significance Single submitter
- LGALS3 p.Pro123Leu Uncertain significance Single submitter
- LGALS3 p.Pro206Arg Uncertain significance Single submitter
- LGALS3 p.Ser237Phe Uncertain significance Single submitter
- LGALS3 p.Tyr101Phe Uncertain significance Single submitter
- LGALS3 p.Tyr107Cys Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- LGALS3 p.Arg129His Uncertain significance Single submitter
- LGALS3 p.Glu230Lys Uncertain significance Single submitter
- LGALS3 p.Gly182Glu Uncertain significance Single submitter
- LGALS3 p.Gly99Arg Uncertain significance Single submitter
- LGALS3 p.Met130Thr Uncertain significance Single submitter
- LGALS3 p.Phe192Leu Uncertain significance Single submitter
- LGALS3 p.Phe198Leu Uncertain significance Single submitter
- LGALS3 p.Pro30Arg Uncertain significance Single submitter
- LGALS3 p.Pro37Thr Uncertain significance Single submitter
- LGALS3 p.Pro42Ser Uncertain significance Single submitter
- LGALS3 p.Pro67Leu Uncertain significance Single submitter
- LGALS3 p.Pro71His Uncertain significance Single submitter
- LGALS3 p.Ser188Leu Uncertain significance Single submitter
- LGALS3 p.Trp26Arg Uncertain significance Single submitter
- LGALS3 p.Val138Met Uncertain significance Single submitter
All LGALS3 variants
Benign 4
- p.Arg183Lys Multiple submitters
- p.Thr98= Multiple submitters
- c.18+7G>A Single submitter
- p.His8= Single submitter
Likely benign 4
Uncertain significance 34
- p.Ala212Val Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg162His Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Asn141Ser Single submitter ⚠
- p.Asn153Lys Single submitter ⚠
- p.Gln187Arg Single submitter ⚠
- p.Glu193Gln Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Gly182Glu Single submitter ⚠
- p.Gly85Val Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His8Arg Single submitter ⚠
- p.Leu135Val Single submitter ⚠
- p.Leu234Arg Single submitter ⚠
- p.Met130Thr Single submitter ⚠
- p.Phe192Leu Single submitter ⚠
- p.Phe198Leu Single submitter ⚠
- p.Phe198Ser Single submitter ⚠
- p.Pro123Leu Single submitter ⚠
- p.Pro206Arg Single submitter ⚠
- p.Pro30Arg Single submitter ⚠
- p.Pro37Thr Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Pro71His Single submitter ⚠
- p.Ser188Leu Single submitter ⚠
- p.Ser237Phe Single submitter ⚠
- p.Trp26Arg Single submitter ⚠
- p.Tyr101Phe Single submitter ⚠
- p.Tyr107Cys Single submitter ⚠
- p.Val138Met Single submitter ⚠