LGALS3BP — 90 ClinVar variants

All ClinVar germline LGALS3BP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →

5 Benign · 7 Likely benign · 78 Uncertain significance

Full LGALS3BP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 76

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 62

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 14

The independent predictors disagree with each other — read with care.

All LGALS3BP variants

Benign 5

p.Arg333= Multiple submitters
p.Arg436Pro Multiple submitters
p.His369= Multiple submitters
p.Phe537= Multiple submitters
p.Thr94= Single submitter

Likely benign 7

p.Ala273Thr Single submitter
p.Arg393Gln Single submitter
p.Asp102Asn Single submitter
p.Pro4Leu Single submitter
p.Ser140= Single submitter
p.Thr2Ala Single submitter
p.Thr94Met Single submitter

Uncertain significance 78

p.Ala248Thr Single submitter ⚠
p.Ala27Thr Single submitter ⚠
p.Ala284Val Single submitter
p.Ala31Ser Single submitter ⚠
p.Ala31Val Single submitter ⚠
p.Ala425Val Single submitter ⚠
p.Ala542Ser Single submitter ⚠
p.Ala543Glu Single submitter ⚠
p.Ala563Val Single submitter ⚠
p.Arg333Cys Single submitter ⚠
p.Arg333His Single submitter ⚠
p.Arg393Trp Single submitter ⚠
p.Arg426Gln Single submitter ⚠
p.Arg426Trp Single submitter ⚠
p.Arg475Ser Single submitter ⚠
p.Arg514His Single submitter ⚠
p.Arg570Cys Single submitter ⚠
p.Arg574His Single submitter ⚠
p.Arg63Trp Single submitter ⚠
p.Asn112Lys Single submitter ⚠
p.Asn160Thr Single submitter ⚠
p.Asn580Asp Single submitter ⚠
p.Asn69Ile Single submitter ⚠
p.Asp154Asn Single submitter
p.Asp21His Single submitter ⚠
p.Asp302Glu Single submitter ⚠
p.Asp302Gly Single submitter ⚠
p.Asp312Asn Single submitter ⚠
p.Asp513Ala Single submitter ⚠
p.Asp536Asn Single submitter ⚠
p.Asp549Ala Single submitter ⚠
p.Cys93Arg Single submitter ⚠
p.Gln162Lys Single submitter ⚠
p.Gln472Lys Single submitter ⚠
p.Glu141Gly Single submitter ⚠
p.Glu318Lys Single submitter ⚠
p.Glu332Asp Single submitter ⚠
p.Glu338Gly Single submitter ⚠
p.Glu500Gln Single submitter ⚠
p.Glu500Lys Single submitter ⚠
p.Glu68Lys Single submitter ⚠
p.Gly144Cys Single submitter ⚠
p.Gly29Arg Single submitter ⚠
p.Gly341Asp Single submitter ⚠
p.Gly505Ser Single submitter ⚠
p.Gly511Ser Single submitter ⚠
p.Gly583Cys Single submitter ⚠
p.Gly84Asp Single submitter ⚠
p.His369Tyr Single submitter ⚠
p.Ile217Val Single submitter ⚠
p.Ile39Met Single submitter ⚠
p.Leu250Pro Single submitter ⚠
p.Leu275Gln Single submitter ⚠
p.Leu290Ser Single submitter ⚠
p.Leu506Phe Single submitter ⚠
p.Leu52Val Single submitter ⚠
p.Leu548Gln Single submitter ⚠
p.Phe361Val Single submitter ⚠
p.Phe417Val Single submitter ⚠
p.Pro316Ser Single submitter ⚠
p.Pro3Ser Single submitter ⚠
p.Pro450Thr Single submitter ⚠
p.Pro562Leu Single submitter ⚠
p.Ser149Arg Single submitter ⚠
p.Ser214Pro Single submitter ⚠
p.Ser329Gly Single submitter ⚠
p.Ser411Leu Single submitter ⚠
p.Ser415Asn Single submitter ⚠
p.Ser443Phe Single submitter ⚠
p.Ser555Asn Single submitter ⚠
p.Thr403Ile Single submitter ⚠
p.Thr413Ile Single submitter ⚠
p.Tyr234His Single submitter ⚠
p.Tyr577Cys Single submitter ⚠
p.Val19Met Single submitter ⚠
p.Val343Ala Single submitter ⚠
p.Val534Ile Single submitter ⚠
p.Val60Ile Single submitter ⚠