LGALS8 — 42 ClinVar variants
All ClinVar germline LGALS8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
2 Benign · 6 Likely benign · 34 Uncertain significance
Full LGALS8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGALS8 p.Ala117Thr Uncertain significance Single submitter
- LGALS8 p.Ala188Thr Uncertain significance Single submitter
- LGALS8 p.Ala73Val Uncertain significance Single submitter
- LGALS8 p.Arg199Gln Uncertain significance Single submitter
- LGALS8 p.Arg69Cys Uncertain significance Single submitter
- LGALS8 p.Arg69Leu Uncertain significance Single submitter
- LGALS8 p.Asn283Asp Uncertain significance Single submitter
- LGALS8 p.Asp217Val Uncertain significance Single submitter
- LGALS8 p.Asp61Val Uncertain significance Single submitter
- LGALS8 p.Cys273Tyr Uncertain significance Single submitter
- LGALS8 p.Glu133Gly Uncertain significance Single submitter
- LGALS8 p.Glu289Gln Uncertain significance Single submitter
- LGALS8 p.Gly120Val Uncertain significance Single submitter
- LGALS8 p.Gly205Arg Uncertain significance Single submitter
- LGALS8 p.Gly221Val Uncertain significance Single submitter
- LGALS8 p.Ile130Thr Uncertain significance Single submitter
- LGALS8 p.Ile76Val Uncertain significance Single submitter
- LGALS8 p.Leu183Pro Uncertain significance Single submitter
- LGALS8 p.Leu191Met Uncertain significance Single submitter
- LGALS8 p.Leu32Phe Uncertain significance Single submitter
- LGALS8 p.Ser316Asn Uncertain significance Single submitter
- LGALS8 p.Thr31Ile Uncertain significance Single submitter
- LGALS8 p.Val106Leu Uncertain significance Single submitter
- LGALS8 p.Val285Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- LGALS8 p.Asn119Ser Uncertain significance Single submitter
- LGALS8 p.His122Arg Uncertain significance Single submitter
- LGALS8 p.Ile149Thr Uncertain significance Single submitter
- LGALS8 p.Leu219Pro Uncertain significance Single submitter
- LGALS8 p.Phe151Leu Uncertain significance Single submitter
- LGALS8 p.Tyr266His Uncertain significance Single submitter
All LGALS8 variants
Benign 2
- c.549+147A>G Multiple submitters
- p.Val201= Multiple submitters
Likely benign 6
- c.549+192A>G Single submitter
- c.549+243A>G Single submitter
- p.Ala73= Single submitter
- p.Gly131Ser Single submitter
- p.Ser164Thr Single submitter
- p.Val203Ile Single submitter
Uncertain significance 34
- c.549+161G>A Single submitter
- c.549+186G>A Single submitter
- c.549+195C>T Single submitter
- p.Ala117Thr Single submitter ⚠
- p.Ala188Thr Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Arg59Gln Single submitter
- p.Arg69Cys Single submitter ⚠
- p.Arg69Leu Single submitter ⚠
- p.Asn119Ser Single submitter ⚠
- p.Asn283Asp Single submitter ⚠
- p.Asp217Val Single submitter ⚠
- p.Asp61Val Single submitter ⚠
- p.Cys273Tyr Single submitter ⚠
- p.Glu133Gly Single submitter ⚠
- p.Glu289Gln Single submitter ⚠
- p.Gly120Val Single submitter ⚠
- p.Gly205Arg Single submitter ⚠
- p.Gly221Val Single submitter ⚠
- p.His122Arg Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile76Val Single submitter ⚠
- p.Leu183Pro Single submitter ⚠
- p.Leu191Met Single submitter ⚠
- p.Leu219Pro Single submitter ⚠
- p.Leu32Phe Single submitter ⚠
- p.Phe151Leu Single submitter ⚠
- p.Ser316Asn Single submitter ⚠
- p.Thr31Ile Single submitter ⚠
- p.Tyr266His Single submitter ⚠
- p.Val106Leu Single submitter ⚠
- p.Val285Ile Single submitter ⚠