LGMN — 81 ClinVar variants
All ClinVar germline LGMN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Benign · 2 Likely benign · 77 Uncertain significance
Full LGMN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LGMN p.Ala371Gly Uncertain significance Single submitter
- LGMN p.Ala371Ser Uncertain significance Single submitter
- LGMN p.Ala49Val Uncertain significance Single submitter
- LGMN p.Ala6Ser Uncertain significance Single submitter
- LGMN p.Arg337Gln Uncertain significance Single submitter
- LGMN p.Arg350His Uncertain significance Single submitter
- LGMN p.Asn196Ser Uncertain significance Single submitter
- LGMN p.Asn211Thr Uncertain significance Single submitter
- LGMN p.Asp107Glu Uncertain significance Single submitter
- LGMN p.Asp107Gly Uncertain significance Single submitter
- LGMN p.Asp340Asn Uncertain significance Single submitter
- LGMN p.Glu369Lys Uncertain significance Single submitter
- LGMN p.Glu413Gln Uncertain significance Single submitter
- LGMN p.Glu78Gln Uncertain significance Single submitter
- LGMN p.Gly230Glu Uncertain significance Single submitter
- LGMN p.Gly84Arg Uncertain significance Single submitter
- LGMN p.His176Tyr Uncertain significance Single submitter
- LGMN p.His301Leu Uncertain significance Single submitter
- LGMN p.His51Arg Uncertain significance Single submitter
- LGMN p.Ile127Val Uncertain significance Single submitter
- LGMN p.Ile15Thr Uncertain significance Single submitter
- LGMN p.Ile345Val Uncertain significance Single submitter
- LGMN p.Ile352Leu Uncertain significance Single submitter
- LGMN p.Ile66Val Uncertain significance Single submitter
- LGMN p.Leu257Pro Uncertain significance Single submitter
- LGMN p.Leu312Val Uncertain significance Single submitter
- LGMN p.Lys125Glu Uncertain significance Single submitter
- LGMN p.Lys253Glu Uncertain significance Single submitter
- LGMN p.Lys273Gln Uncertain significance Single submitter
- LGMN p.Met320Ile Uncertain significance Single submitter
- LGMN p.Met425Val Uncertain significance Single submitter
- LGMN p.Met70Leu Uncertain significance Single submitter
- LGMN p.Pro293Ser Uncertain significance Single submitter
- LGMN p.Pro295Leu Uncertain significance Single submitter
- LGMN p.Pro372Arg Uncertain significance Single submitter
- LGMN p.Pro415Leu Uncertain significance Single submitter
- LGMN p.Ser215Leu Uncertain significance Single submitter
- LGMN p.Ser260Leu Uncertain significance Single submitter
- LGMN p.Ser307Gly Uncertain significance Single submitter
- LGMN p.Thr104Ala Uncertain significance Single submitter
- LGMN p.Thr146Pro Uncertain significance Single submitter
- LGMN p.Thr227Met Uncertain significance Single submitter
- LGMN p.Thr374Met Uncertain significance Single submitter
- LGMN p.Tyr185Cys Uncertain significance Single submitter
- LGMN p.Tyr76Cys Uncertain significance Single submitter
- LGMN p.Val141Met Uncertain significance Single submitter
- LGMN p.Val235Ile Uncertain significance Single submitter
- LGMN p.Val299Asp Uncertain significance Single submitter
- LGMN p.Val353Ile Uncertain significance Single submitter
- LGMN p.Val363Met Uncertain significance Single submitter
- LGMN p.Val428Leu Uncertain significance Single submitter
-
LGMN p.His404Arg
Uncertain significance
No assertion criteria
High myopia
Predictors split 21
The independent predictors disagree with each other — read with care.
- LGMN p.Ala123Glu Uncertain significance Single submitter
- LGMN p.Ala218Thr Uncertain significance Single submitter
- LGMN p.Ala75Ser Uncertain significance Single submitter
- LGMN p.Arg350Cys Uncertain significance Single submitter
- LGMN p.Arg403Gly Uncertain significance Single submitter
- LGMN p.Arg58Cys Uncertain significance Single submitter
- LGMN p.Asn91Ser Uncertain significance Single submitter
- LGMN p.Asp242Glu Uncertain significance Single submitter
- LGMN p.Asp309Asn Uncertain significance Single submitter
- LGMN p.Gly130Ser Uncertain significance Single submitter
- LGMN p.Leu114Arg Uncertain significance Single submitter
- LGMN p.Lys101Gln Uncertain significance Single submitter
- LGMN p.Met315Ile Uncertain significance Single submitter
- LGMN p.Pro137Leu Uncertain significance Single submitter
- LGMN p.Thr109Ala Uncertain significance Single submitter
- LGMN p.Val116Leu Uncertain significance Single submitter
- LGMN p.Val267Ile Uncertain significance Single submitter
- LGMN p.Val310Ala Uncertain significance Single submitter
- LGMN p.Val34Met Uncertain significance Single submitter
- LGMN p.Val407Met Uncertain significance Single submitter
- LGMN p.Val95Ile Uncertain significance Single submitter
All LGMN variants
Benign 2
- c.1259+9T>C Multiple submitters
- p.Tyr255= Multiple submitters
Likely benign 2
- p.Arg180Gln Single submitter
- p.Pro100Leu Single submitter
Uncertain significance 77
- p.Ala123Glu Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala371Gly Single submitter ⚠
- p.Ala371Ser Single submitter ⚠
- p.Ala49Val Single submitter ⚠
- p.Ala6Ser Single submitter ⚠
- p.Ala75Ser Single submitter ⚠
- p.Arg337Gln Single submitter ⚠
- p.Arg350Cys Single submitter ⚠
- p.Arg350His Single submitter ⚠
- p.Arg403Gly Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Asn196Ser Single submitter ⚠
- p.Asn211Thr Single submitter ⚠
- p.Asn91Ser Single submitter ⚠
- p.Asp107Glu Single submitter ⚠
- p.Asp107Gly Single submitter ⚠
- p.Asp242Glu Single submitter ⚠
- p.Asp309Asn Single submitter ⚠
- p.Asp340Asn Single submitter ⚠
- p.Glu369Lys Single submitter ⚠
- p.Glu413Gln Single submitter ⚠
- p.Glu78Gln Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly84Arg Single submitter ⚠
- p.His140Gln Single submitter
- p.His176Tyr Single submitter ⚠
- p.His301Leu Single submitter ⚠
- p.His51Arg Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Ile15Thr Single submitter ⚠
- p.Ile345Val Single submitter ⚠
- p.Ile352Leu Single submitter ⚠
- p.Ile66Val Single submitter ⚠
- p.Leu114Arg Single submitter ⚠
- p.Leu257Pro Single submitter ⚠
- p.Leu312Val Single submitter ⚠
- p.Lys101Gln Single submitter ⚠
- p.Lys125Glu Single submitter ⚠
- p.Lys253Glu Single submitter ⚠
- p.Lys273Gln Single submitter ⚠
- p.Met315Ile Single submitter ⚠
- p.Met320Ile Single submitter ⚠
- p.Met425Val Single submitter ⚠
- p.Met70Leu Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro293Ser Single submitter ⚠
- p.Pro295Leu Single submitter ⚠
- p.Pro372Arg Single submitter ⚠
- p.Pro415Leu Single submitter ⚠
- p.Ser215Leu Single submitter ⚠
- p.Ser260Leu Single submitter ⚠
- p.Ser307Gly Single submitter ⚠
- p.Thr104Ala Single submitter ⚠
- p.Thr109Ala Single submitter ⚠
- p.Thr146Pro Single submitter ⚠
- p.Thr227Met Single submitter ⚠
- p.Thr374Met Single submitter ⚠
- p.Tyr144Asn Single submitter
- p.Tyr185Cys Single submitter ⚠
- p.Tyr221His Single submitter
- p.Tyr76Cys Single submitter ⚠
- p.Val116Leu Single submitter ⚠
- p.Val141Met Single submitter ⚠
- p.Val235Ile Single submitter ⚠
- p.Val267Ile Single submitter ⚠
- p.Val299Asp Single submitter ⚠
- p.Val310Ala Single submitter ⚠
- p.Val34Met Single submitter ⚠
- p.Val353Ile Single submitter ⚠
- p.Val363Met Single submitter ⚠
- p.Val407Met Single submitter ⚠
- p.Val428Leu Single submitter ⚠
- p.Val86Met Single submitter
- p.Val95Ile Single submitter ⚠
- p.His404Arg No assertion criteria High myopia ⚠