Sugi Variant

Sugi Variant/LIG1

LIG1 — 814 ClinVar variants

All ClinVar germline LIG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 280 flagged for review →

2 Pathogenic · 1 Likely pathogenic · 8 Conflicting · 45 Benign · 19 Benign/Likely benign · 417 Likely benign · 322 Uncertain significance

Full LIG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 280

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 196

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 196

Predictors split 80

The independent predictors disagree with each other — read with care.

All LIG1 variants

Pathogenic 2

Likely pathogenic 1

Conflicting classifications of pathogenicity 8

Benign 45

Benign/Likely benign 19

Likely benign 417

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 322

Showing the top 300 by review status; the full set is in the sitemap.