LIMA1 — 113 ClinVar variants
All ClinVar germline LIMA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
16 Likely benign · 97 Uncertain significance
Full LIMA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LIMA1 p.Ala113Gly Uncertain significance Single submitter
- LIMA1 p.Ala136Val Uncertain significance Single submitter
- LIMA1 p.Ala183Asp Uncertain significance Single submitter
- LIMA1 p.Ala214Ser Uncertain significance Single submitter
- LIMA1 p.Ala367Val Uncertain significance Single submitter
- LIMA1 p.Ala479Val Uncertain significance Single submitter
- LIMA1 p.Ala531Thr Uncertain significance Single submitter
- LIMA1 p.Arg141Gln Uncertain significance Single submitter
- LIMA1 p.Arg213Trp Uncertain significance Single submitter
- LIMA1 p.Arg402Cys Uncertain significance Single submitter
- LIMA1 p.Arg416His Uncertain significance Single submitter
- LIMA1 p.Arg54Ile Uncertain significance Single submitter
- LIMA1 p.Arg633Thr Uncertain significance Single submitter
- LIMA1 p.Arg91Trp Uncertain significance Single submitter
- LIMA1 p.Arg98Met Uncertain significance Single submitter
- LIMA1 p.Arg98Thr Uncertain significance Single submitter
- LIMA1 p.Arg9Gln Uncertain significance Single submitter
- LIMA1 p.Arg9Trp Uncertain significance Single submitter
- LIMA1 p.Asn180Lys Uncertain significance Single submitter
- LIMA1 p.Asn191Asp Uncertain significance Single submitter
- LIMA1 p.Asn29Lys Uncertain significance Single submitter
- LIMA1 p.Asn406Ser Uncertain significance Single submitter
- LIMA1 p.Asn471Asp Uncertain significance Single submitter
- LIMA1 p.Asn471Lys Uncertain significance Single submitter
- LIMA1 p.Asp119Asn Uncertain significance Single submitter
- LIMA1 p.Asp147Ala Uncertain significance Single submitter
- LIMA1 p.Asp687Asn Uncertain significance Single submitter
- LIMA1 p.Asp687Val Uncertain significance Single submitter
- LIMA1 p.Cys438Phe Uncertain significance Single submitter
- LIMA1 p.Gln62Arg Uncertain significance Single submitter
- LIMA1 p.Gln696Pro Uncertain significance Single submitter
- LIMA1 p.Gln700Arg Uncertain significance Single submitter
- LIMA1 p.Glu121Gln Uncertain significance Single submitter
- LIMA1 p.Glu179Lys Uncertain significance Single submitter
- LIMA1 p.Glu304Asp Uncertain significance Single submitter
- LIMA1 p.Glu472Lys Uncertain significance Single submitter
- LIMA1 p.Glu566Lys Uncertain significance Single submitter
- LIMA1 p.Glu624Asp Uncertain significance Single submitter
- LIMA1 p.Glu657Asp Uncertain significance Single submitter
- LIMA1 p.Gly427Arg Uncertain significance Single submitter
- LIMA1 p.Gly649Arg Uncertain significance Single submitter
- LIMA1 p.Gly649Glu Uncertain significance Single submitter
- LIMA1 p.Gly683Ala Uncertain significance Single submitter
- LIMA1 p.Gly683Asp Uncertain significance Single submitter
- LIMA1 p.His125Arg Uncertain significance Single submitter
- LIMA1 p.His99Gln Uncertain significance Single submitter
- LIMA1 p.Ile412Phe Uncertain significance Single submitter
- LIMA1 p.Ile498Val Uncertain significance Single submitter
- LIMA1 p.Leu151Ile Uncertain significance Single submitter
- LIMA1 p.Leu361Arg Uncertain significance Single submitter
- LIMA1 p.Leu370Phe Uncertain significance Single submitter
- LIMA1 p.Leu370Pro Uncertain significance Single submitter
- LIMA1 p.Leu432Ser Uncertain significance Single submitter
- LIMA1 p.Leu545Phe Uncertain significance Single submitter
- LIMA1 p.Leu672Ser Uncertain significance Single submitter
- LIMA1 p.Lys159Gln Uncertain significance Single submitter
- LIMA1 p.Lys210Glu Uncertain significance Single submitter
- LIMA1 p.Lys349Arg Uncertain significance Single submitter
- LIMA1 p.Lys603Thr Uncertain significance Single submitter
- LIMA1 p.Lys695Thr Uncertain significance Single submitter
- LIMA1 p.Lys703Glu Uncertain significance Single submitter
- LIMA1 p.Met508Leu Uncertain significance Single submitter
- LIMA1 p.Met508Val Uncertain significance Single submitter
- LIMA1 p.Met618Val Uncertain significance Single submitter
- LIMA1 p.Phe64Val Uncertain significance Single submitter
- LIMA1 p.Pro133Leu Uncertain significance Single submitter
- LIMA1 p.Pro206Arg Uncertain significance Single submitter
- LIMA1 p.Pro535His Uncertain significance Single submitter
- LIMA1 p.Ser184Leu Uncertain significance Single submitter
- LIMA1 p.Ser279Cys Uncertain significance Single submitter
- LIMA1 p.Ser346Phe Uncertain significance Single submitter
- LIMA1 p.Ser601Phe Uncertain significance Single submitter
- LIMA1 p.Ser617Gly Uncertain significance Single submitter
- LIMA1 p.Ser625Pro Uncertain significance Single submitter
- LIMA1 p.Ser666Arg Uncertain significance Single submitter
- LIMA1 p.Ser708Leu Uncertain significance Single submitter
- LIMA1 p.Thr714Ile Uncertain significance Single submitter
- LIMA1 p.Thr87Arg Uncertain significance Single submitter
- LIMA1 p.Trp556Arg Uncertain significance Single submitter
- LIMA1 p.Tyr229Cys Uncertain significance Single submitter
- LIMA1 p.Tyr229Ser Uncertain significance Single submitter
- LIMA1 p.Val391Met Uncertain significance Single submitter
- LIMA1 p.Val636Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- LIMA1 p.Arg589Pro Uncertain significance Single submitter
- LIMA1 p.Arg750Leu Uncertain significance Single submitter
- LIMA1 p.Asn451Ser Uncertain significance Single submitter
- LIMA1 p.Lys747Glu Uncertain significance Single submitter
- LIMA1 p.Met200Thr Uncertain significance Single submitter
- LIMA1 p.Met508Ile Uncertain significance Single submitter
- LIMA1 p.Ser741Ala Uncertain significance Single submitter
- LIMA1 p.Val18Leu Uncertain significance Single submitter
All LIMA1 variants
Likely benign 16
- c.715+10G>A Single submitter
- c.973-6_973-5del Single submitter
- c.973-8_973-5del Single submitter
- p.Ala83= Single submitter
- p.Arg335His Single submitter
- p.Glu122= Single submitter
- p.His489= Single submitter
- p.Ile530= Single submitter
- p.Pro79= Single submitter
- p.Ser248Leu Single submitter
- p.Ser642= Single submitter
- p.Thr592= Single submitter
- p.Val138Ile Single submitter
- c.973-4G>T No assertion criteria LIMA1-related disorder
- p.Arg129= No assertion criteria LIMA1-related disorder
- p.Leu90= No assertion criteria LIMA1-related disorder
Uncertain significance 97
- p.Ala113Gly Single submitter ⚠
- p.Ala136Val Single submitter ⚠
- p.Ala183Asp Single submitter ⚠
- p.Ala214Ser Single submitter ⚠
- p.Ala367Val Single submitter ⚠
- p.Ala479Val Single submitter ⚠
- p.Ala531Thr Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg402Cys Single submitter ⚠
- p.Arg416His Single submitter ⚠
- p.Arg54Ile Single submitter ⚠
- p.Arg580Gln Single submitter
- p.Arg589Pro Single submitter ⚠
- p.Arg633Thr Single submitter ⚠
- p.Arg750Leu Single submitter ⚠
- p.Arg91Trp Single submitter ⚠
- p.Arg98Met Single submitter ⚠
- p.Arg98Thr Single submitter ⚠
- p.Arg9Gln Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asn180Lys Single submitter ⚠
- p.Asn191Asp Single submitter ⚠
- p.Asn29Lys Single submitter ⚠
- p.Asn406Ser Single submitter ⚠
- p.Asn451Ser Single submitter ⚠
- p.Asn471Asp Single submitter ⚠
- p.Asn471Lys Single submitter ⚠
- p.Asp119Asn Single submitter ⚠
- p.Asp147Ala Single submitter ⚠
- p.Asp687Asn Single submitter ⚠
- p.Asp687Val Single submitter ⚠
- p.Asp753His Single submitter
- p.Cys438Phe Single submitter ⚠
- p.Gln62Arg Single submitter ⚠
- p.Gln696Pro Single submitter ⚠
- p.Gln700Arg Single submitter ⚠
- p.Gln745Arg Single submitter
- p.Glu121Gln Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Glu188Gln Single submitter
- p.Glu304Asp Single submitter ⚠
- p.Glu472Lys Single submitter ⚠
- p.Glu566Lys Single submitter ⚠
- p.Glu624Asp Single submitter ⚠
- p.Glu657Asp Single submitter ⚠
- p.Gly427Arg Single submitter ⚠
- p.Gly649Arg Single submitter ⚠
- p.Gly649Glu Single submitter ⚠
- p.Gly683Ala Single submitter ⚠
- p.Gly683Asp Single submitter ⚠
- p.His125Arg Single submitter ⚠
- p.His433Tyr Single submitter
- p.His99Gln Single submitter ⚠
- p.Ile412Phe Single submitter ⚠
- p.Ile498Val Single submitter ⚠
- p.Leu151Ile Single submitter ⚠
- p.Leu361Arg Single submitter ⚠
- p.Leu370Phe Single submitter ⚠
- p.Leu370Pro Single submitter ⚠
- p.Leu432Ser Single submitter ⚠
- p.Leu545Phe Single submitter ⚠
- p.Leu672Ser Single submitter ⚠
- p.Lys159Gln Single submitter ⚠
- p.Lys210Glu Single submitter ⚠
- p.Lys349Arg Single submitter ⚠
- p.Lys603Thr Single submitter ⚠
- p.Lys695Thr Single submitter ⚠
- p.Lys703Glu Single submitter ⚠
- p.Lys747Glu Single submitter ⚠
- p.Met200Thr Single submitter ⚠
- p.Met508Ile Single submitter ⚠
- p.Met508Leu Single submitter ⚠
- p.Met508Val Single submitter ⚠
- p.Met618Val Single submitter ⚠
- p.Phe64Val Single submitter ⚠
- p.Pro133Leu Single submitter ⚠
- p.Pro206Arg Single submitter ⚠
- p.Pro535His Single submitter ⚠
- p.Ser184Leu Single submitter ⚠
- p.Ser279Cys Single submitter ⚠
- p.Ser346Phe Single submitter ⚠
- p.Ser369Arg Single submitter
- p.Ser601Phe Single submitter ⚠
- p.Ser617Gly Single submitter ⚠
- p.Ser625Pro Single submitter ⚠
- p.Ser666Arg Single submitter ⚠
- p.Ser708Leu Single submitter ⚠
- p.Ser741Ala Single submitter ⚠
- p.Thr714Ile Single submitter ⚠
- p.Thr87Arg Single submitter ⚠
- p.Trp556Arg Single submitter ⚠
- p.Tyr229Cys Single submitter ⚠
- p.Tyr229Ser Single submitter ⚠
- p.Val18Leu Single submitter ⚠
- p.Val391Met Single submitter ⚠
- p.Val636Met Single submitter ⚠