LIMK2 — 105 ClinVar variants
All ClinVar germline LIMK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Benign · 3 Likely benign · 100 Uncertain significance
Full LIMK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LIMK2 p.Ala172Gly Uncertain significance Single submitter
- LIMK2 p.Ala254Val Uncertain significance Single submitter
- LIMK2 p.Ala436Thr Uncertain significance Single submitter
- LIMK2 p.Arg11Gly Uncertain significance Single submitter
- LIMK2 p.Arg187Gln Uncertain significance Single submitter
- LIMK2 p.Arg243His Uncertain significance Single submitter
- LIMK2 p.Arg248Trp Uncertain significance Single submitter
- LIMK2 p.Arg252Trp Uncertain significance Single submitter
- LIMK2 p.Arg280Lys Uncertain significance Single submitter
- LIMK2 p.Arg307His Uncertain significance Single submitter
- LIMK2 p.Arg311Cys Uncertain significance Single submitter
- LIMK2 p.Arg364Leu Uncertain significance Single submitter
- LIMK2 p.Arg418Cys Uncertain significance Single submitter
- LIMK2 p.Arg418His Uncertain significance Single submitter
- LIMK2 p.Arg493His Uncertain significance Single submitter
- LIMK2 p.Arg496His Uncertain significance Single submitter
- LIMK2 p.Arg634Gln Uncertain significance Single submitter
- LIMK2 p.Arg634Gly Uncertain significance Single submitter
- LIMK2 p.Arg634Trp Uncertain significance Single submitter
- LIMK2 p.Asn259Asp Uncertain significance Single submitter
- LIMK2 p.Asn49Ser Uncertain significance Single submitter
- LIMK2 p.Asp8Glu Uncertain significance Single submitter
- LIMK2 p.Cys317Tyr Uncertain significance Single submitter
- LIMK2 p.Glu218Lys Uncertain significance Single submitter
- LIMK2 p.Glu335Val Uncertain significance Single submitter
- LIMK2 p.Gly16Glu Uncertain significance Single submitter
- LIMK2 p.Gly261Arg Uncertain significance Single submitter
- LIMK2 p.Gly334Arg Uncertain significance Single submitter
- LIMK2 p.Gly631Ser Uncertain significance Single submitter
- LIMK2 p.His262Arg Uncertain significance Single submitter
- LIMK2 p.Ile204Val Uncertain significance Single submitter
- LIMK2 p.Ile325Asn Uncertain significance Single submitter
- LIMK2 p.Ile346Val Uncertain significance Single submitter
- LIMK2 p.Ile476Leu Uncertain significance Single submitter
- LIMK2 p.Ile540Thr Uncertain significance Single submitter
- LIMK2 p.Leu554Val Uncertain significance Single submitter
- LIMK2 p.Lys57Arg Uncertain significance Single submitter
- LIMK2 p.Phe38Val Uncertain significance Single submitter
- LIMK2 p.Pro302Ser Uncertain significance Single submitter
- LIMK2 p.Pro61Arg Uncertain significance Single submitter
- LIMK2 p.Ser310Gly Uncertain significance Single submitter
- LIMK2 p.Ser318Thr Uncertain significance Single submitter
- LIMK2 p.Ser36Pro Uncertain significance Single submitter
- LIMK2 p.Ser454Leu Uncertain significance Single submitter
- LIMK2 p.Thr151Met Uncertain significance Single submitter
- LIMK2 p.Thr28Pro Uncertain significance Single submitter
- LIMK2 p.Thr625Ile Uncertain significance Single submitter
- LIMK2 p.Val103Ala Uncertain significance Single submitter
- LIMK2 p.Val169Met Uncertain significance Single submitter
- LIMK2 p.Val212Ile Uncertain significance Single submitter
- LIMK2 p.Val240Ile Uncertain significance Single submitter
- LIMK2 p.Val9Asp Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- LIMK2 p.Arg203Cys Uncertain significance Single submitter
- LIMK2 p.Arg39Trp Uncertain significance Single submitter
- LIMK2 p.Asp421Val Uncertain significance Single submitter
- LIMK2 p.Glu367Lys Uncertain significance Single submitter
-
LIMK2 p.Gly295Asp
Uncertain significance
Single submitter
volvulus of midgut
- LIMK2 p.Ile392Leu Uncertain significance Single submitter
- LIMK2 p.Leu389Val Uncertain significance Single submitter
- LIMK2 p.Pro578Leu Uncertain significance Single submitter
- LIMK2 p.Tyr52Cys Uncertain significance Single submitter
- LIMK2 p.Val180Met Uncertain significance Single submitter
- LIMK2 p.Val543Met Uncertain significance Single submitter
All LIMK2 variants
Likely benign 3
- p.Ala265Thr Single submitter
- p.Arg252Gln Single submitter
- p.Met628Val Single submitter
Uncertain significance 100
- c.117-9526T>A Single submitter
- c.117-9537C>A Single submitter
- c.117-9538T>G Single submitter
- c.1772+1483C>A Single submitter
- c.1772+1486C>A Single submitter
- c.1772+1488C>A Single submitter
- c.1772+1488C>G Single submitter
- c.1772+1489C>G Single submitter
- c.1773-1164A>G Single submitter
- c.1773-1191C>A Single submitter
- c.1773-1204G>A Single submitter
- c.1773-1204G>C Single submitter
- c.1773-1206T>C Single submitter
- c.1773-1216T>A Single submitter
- c.1773-1236A>G Single submitter
- c.1773-1236A>T Single submitter
- c.1773-1269C>G Single submitter
- c.1773-1293T>G Single submitter
- c.1773-1312G>A Single submitter
- c.1773-1316T>G Single submitter
- c.1773-1318A>G Single submitter
- c.1773-1334G>T Single submitter
- c.1773-1350A>G Single submitter
- c.1773-1362C>G Single submitter
- c.1773-1363A>G Single submitter
- c.1773-1366C>T Single submitter
- c.1773-1382G>T Single submitter
- c.1773-1399C>T Single submitter
- c.1773-1402A>C Single submitter
- c.1773-1479C>T Single submitter
- p.Ala172Gly Single submitter ⚠
- p.Ala254Val Single submitter ⚠
- p.Ala436Thr Single submitter ⚠
- p.Arg11Gly Single submitter ⚠
- p.Arg163Gln Single submitter
- p.Arg187Gln Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg203Gly Single submitter
- p.Arg243His Single submitter ⚠
- p.Arg248Trp Single submitter ⚠
- p.Arg252Trp Single submitter ⚠
- p.Arg280Lys Single submitter ⚠
- p.Arg282Cys Single submitter
- p.Arg282His Single submitter
- p.Arg307His Single submitter ⚠
- p.Arg311Cys Single submitter ⚠
- p.Arg316His Single submitter
- p.Arg364Leu Single submitter ⚠
- p.Arg39Trp Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg418His Single submitter ⚠
- p.Arg493His Single submitter ⚠
- p.Arg496His Single submitter ⚠
- p.Arg634Gln Single submitter ⚠
- p.Arg634Gly Single submitter ⚠
- p.Arg634Trp Single submitter ⚠
- p.Asn259Asp Single submitter ⚠
- p.Asn49Ser Single submitter ⚠
- p.Asp421Val Single submitter ⚠
- p.Asp8Glu Single submitter ⚠
- p.Cys317Tyr Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Glu335Val Single submitter ⚠
- p.Glu367Lys Single submitter ⚠
- p.Gly16Glu Single submitter ⚠
- p.Gly261Arg Single submitter ⚠
- p.Gly295Asp Single submitter volvulus of midgut ⚠
- p.Gly334Arg Single submitter ⚠
- p.Gly609Arg Single submitter
- p.Gly631Ser Single submitter ⚠
- p.His262Arg Single submitter ⚠
- p.Ile204Val Single submitter ⚠
- p.Ile325Asn Single submitter ⚠
- p.Ile346Val Single submitter ⚠
- p.Ile392Leu Single submitter ⚠
- p.Ile476Leu Single submitter ⚠
- p.Ile540Thr Single submitter ⚠
- p.Leu389Val Single submitter ⚠
- p.Leu554Val Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Phe38Val Single submitter ⚠
- p.Pro294Leu Single submitter
- p.Pro302Ser Single submitter ⚠
- p.Pro578Leu Single submitter ⚠
- p.Pro61Arg Single submitter ⚠
- p.Ser310Gly Single submitter ⚠
- p.Ser318Thr Single submitter ⚠
- p.Ser36Pro Single submitter ⚠
- p.Ser454Leu Single submitter ⚠
- p.Thr151Met Single submitter ⚠
- p.Thr28Pro Single submitter ⚠
- p.Thr625Ile Single submitter ⚠
- p.Tyr52Cys Single submitter ⚠
- p.Val103Ala Single submitter ⚠
- p.Val169Met Single submitter ⚠
- p.Val180Met Single submitter ⚠
- p.Val212Ile Single submitter ⚠
- p.Val240Ile Single submitter ⚠
- p.Val543Met Single submitter ⚠
- p.Val9Asp Single submitter ⚠