LIMS1 — 64 ClinVar variants
All ClinVar germline LIMS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
2 Benign · 2 Likely benign · 60 Uncertain significance
Full LIMS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LIMS1 c.33-4433A>G Uncertain significance Multiple submitters
- LIMS1 p.Arg24Cys Uncertain significance Multiple submitters
- LIMS1 c.33-4355C>T Uncertain significance Single submitter
- LIMS1 c.33-4389G>A Uncertain significance Single submitter
- LIMS1 c.33-4413A>C Uncertain significance Single submitter
- LIMS1 c.33-4428G>A Uncertain significance Single submitter
- LIMS1 c.33-4450C>G Uncertain significance Single submitter
- LIMS1 c.33-4458A>G Uncertain significance Single submitter
- LIMS1 c.33-4467G>A Uncertain significance Single submitter
- LIMS1 c.33-4484A>G Uncertain significance Single submitter
- LIMS1 c.33-4485G>A Uncertain significance Single submitter
- LIMS1 c.33-4509C>T Uncertain significance Single submitter
- LIMS1 p.Ala20Thr Uncertain significance Single submitter
- LIMS1 p.Ala30Val Uncertain significance Single submitter
- LIMS1 p.Ala32Thr Uncertain significance Single submitter
- LIMS1 p.Arg209Gln Uncertain significance Single submitter
- LIMS1 p.Arg210Gln Uncertain significance Single submitter
- LIMS1 p.Arg215Cys Uncertain significance Single submitter
- LIMS1 p.Arg269Cys Uncertain significance Single submitter
- LIMS1 p.Arg269His Uncertain significance Single submitter
- LIMS1 p.Arg93Gln Uncertain significance Single submitter
- LIMS1 p.Asn175Ser Uncertain significance Single submitter
- LIMS1 p.Asp155Asn Uncertain significance Single submitter
- LIMS1 p.Asp307Tyr Uncertain significance Single submitter
- LIMS1 p.Cys234Tyr Uncertain significance Single submitter
- LIMS1 p.Cys315Tyr Uncertain significance Single submitter
- LIMS1 p.Cys71Arg Uncertain significance Single submitter
- LIMS1 p.Cys82Ser Uncertain significance Single submitter
- LIMS1 p.Glu33Lys Uncertain significance Single submitter
- LIMS1 p.Gly40Val Uncertain significance Single submitter
- LIMS1 p.Gly67Glu Uncertain significance Single submitter
- LIMS1 p.His73Leu Uncertain significance Single submitter
- LIMS1 p.Ile146Val Uncertain significance Single submitter
- LIMS1 p.Leu191Gln Uncertain significance Single submitter
- LIMS1 p.Lys233Met Uncertain significance Single submitter
- LIMS1 p.Lys300Glu Uncertain significance Single submitter
- LIMS1 p.Thr21Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- LIMS1 p.Val285Met Benign Multiple submitters
- LIMS1 c.33-4350T>C Uncertain significance Single submitter
- LIMS1 c.33-4369C>A Uncertain significance Single submitter
- LIMS1 p.Arg108Cys Uncertain significance Single submitter
- LIMS1 p.Arg136His Uncertain significance Single submitter
- LIMS1 p.Glu179Gln Uncertain significance Single submitter
- LIMS1 p.Glu179Val Uncertain significance Single submitter
- LIMS1 p.Glu59Lys Uncertain significance Single submitter
- LIMS1 p.Gly177Arg Uncertain significance Single submitter
- LIMS1 p.Leu159Val Uncertain significance Single submitter
- LIMS1 p.Phe48Leu Uncertain significance Single submitter
- LIMS1 p.Phe62Ile Uncertain significance Single submitter
- LIMS1 p.Ser19Arg Uncertain significance Single submitter
- LIMS1 p.Val36Met Uncertain significance Single submitter
All LIMS1 variants
Benign 2
- c.824-6C>G Multiple submitters
- p.Val285Met Multiple submitters ⚠
Likely benign 2
- c.33-4472G>A Single submitter
- c.33-4511C>T Single submitter
Uncertain significance 60
- c.33-4433A>G Multiple submitters ⚠
- p.Arg24Cys Multiple submitters ⚠
- c.33-38168A>G Single submitter
- c.33-38184G>A Single submitter
- c.33-38189G>A Single submitter
- c.33-38195G>A Single submitter
- c.33-38201G>A Single submitter
- c.33-4350T>C Single submitter ⚠
- c.33-4355C>T Single submitter ⚠
- c.33-4369C>A Single submitter ⚠
- c.33-4389G>A Single submitter ⚠
- c.33-4401A>G Single submitter
- c.33-4403G>T Single submitter
- c.33-4413A>C Single submitter ⚠
- c.33-4428G>A Single submitter ⚠
- c.33-4450C>G Single submitter ⚠
- c.33-4458A>G Single submitter ⚠
- c.33-4467G>A Single submitter ⚠
- c.33-4484A>G Single submitter ⚠
- c.33-4485G>A Single submitter ⚠
- c.33-4509C>T Single submitter ⚠
- p.Ala20Thr Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg209Gln Single submitter ⚠
- p.Arg210Gln Single submitter ⚠
- p.Arg215Cys Single submitter ⚠
- p.Arg269Cys Single submitter ⚠
- p.Arg269His Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asn175Ser Single submitter ⚠
- p.Asp155Asn Single submitter ⚠
- p.Asp307Tyr Single submitter ⚠
- p.Cys234Tyr Single submitter ⚠
- p.Cys315Tyr Single submitter ⚠
- p.Cys71Arg Single submitter ⚠
- p.Cys82Ser Single submitter ⚠
- p.Glu179Gln Single submitter ⚠
- p.Glu179Val Single submitter ⚠
- p.Glu23Lys Single submitter
- p.Glu272Gln Single submitter
- p.Glu33Lys Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Gly177Arg Single submitter ⚠
- p.Gly40Val Single submitter ⚠
- p.Gly67Glu Single submitter ⚠
- p.His73Leu Single submitter ⚠
- p.Ile146Val Single submitter ⚠
- p.Leu159Val Single submitter ⚠
- p.Leu191Gln Single submitter ⚠
- p.Lys233Met Single submitter ⚠
- p.Lys300Glu Single submitter ⚠
- p.Phe48Leu Single submitter ⚠
- p.Phe62Ile Single submitter ⚠
- p.Ser19Arg Single submitter ⚠
- p.Thr21Ala Single submitter ⚠
- p.Thr292Ile Single submitter
- p.Val36Met Single submitter ⚠