LIN28A — 24 ClinVar variants
All ClinVar germline LIN28A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
1 Benign · 23 Uncertain significance
Full LIN28A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LIN28A p.Leu176Val Uncertain significance Multiple submitters
- LIN28A p.Ala16Thr Uncertain significance Single submitter
- LIN28A p.Ala32Thr Uncertain significance Single submitter
- LIN28A p.Ala32Val Uncertain significance Single submitter
- LIN28A p.Ala92Ser Uncertain significance Single submitter
- LIN28A p.Arg192Gln Uncertain significance Single submitter
- LIN28A p.Arg61Ser Uncertain significance Single submitter
- LIN28A p.Arg85Trp Uncertain significance Single submitter
- LIN28A p.Asn141Ser Uncertain significance Single submitter
- LIN28A p.Glu196Gly Uncertain significance Single submitter
- LIN28A p.Glu26Lys Uncertain significance Single submitter
- LIN28A p.Glu34Lys Uncertain significance Single submitter
- LIN28A p.Gly186Glu Uncertain significance Single submitter
- LIN28A p.Pro175Leu Uncertain significance Single submitter
- LIN28A p.Pro182Ala Uncertain significance Single submitter
- LIN28A p.Thr189Ile Uncertain significance Single submitter
- LIN28A p.Thr202Ile Uncertain significance Single submitter
- LIN28A p.Tyr140His Uncertain significance Single submitter
- LIN28A p.Tyr190Asp Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All LIN28A variants
Benign 1
- p.Ala29= Multiple submitters
Uncertain significance 23
- p.Leu176Val Multiple submitters ⚠
- p.Ala16Thr Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Ala92Ser Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg61Ser Single submitter ⚠
- p.Arg85Trp Single submitter ⚠
- p.Asn141Ser Single submitter ⚠
- p.Gln7Ter Single submitter
- p.Glu196Gly Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Gly186Glu Single submitter ⚠
- p.Gly2Val Single submitter ⚠
- p.Lys98Asn Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro182Ala Single submitter ⚠
- p.Thr189Ile Single submitter ⚠
- p.Thr202Ile Single submitter ⚠
- p.Tyr140His Single submitter ⚠
- p.Tyr190Asp Single submitter ⚠