LINGO4 — 98 ClinVar variants
All ClinVar germline LINGO4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 91 flagged for review →
1 Conflicting · 3 Likely benign · 94 Uncertain significance
Full LINGO4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 91
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
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LINGO4 p.Ser284Phe
Conflicting
Single submitter
polymicrogyria
Predictors lean, ClinVar uncertain 73
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LINGO4 p.Ala151Val Uncertain significance Single submitter
- LINGO4 p.Ala335Thr Uncertain significance Single submitter
- LINGO4 p.Ala431Val Uncertain significance Single submitter
- LINGO4 p.Ala442Thr Uncertain significance Single submitter
- LINGO4 p.Ala533Ser Uncertain significance Single submitter
- LINGO4 p.Arg140His Uncertain significance Single submitter
- LINGO4 p.Arg189Gly Uncertain significance Single submitter
- LINGO4 p.Arg189His Uncertain significance Single submitter
- LINGO4 p.Arg202Cys Uncertain significance Single submitter
- LINGO4 p.Arg225Gln Uncertain significance Single submitter
- LINGO4 p.Arg261Cys Uncertain significance Single submitter
- LINGO4 p.Arg261His Uncertain significance Single submitter
- LINGO4 p.Arg365Cys Uncertain significance Single submitter
- LINGO4 p.Arg365His Uncertain significance Single submitter
- LINGO4 p.Arg371Gln Uncertain significance Single submitter
- LINGO4 p.Arg374His Uncertain significance Single submitter
- LINGO4 p.Arg416Gln Uncertain significance Single submitter
- LINGO4 p.Arg416Gly Uncertain significance Single submitter
-
LINGO4 p.Arg421Gln
Uncertain significance
Single submitter
polymicrogyria
- LINGO4 p.Arg472His Uncertain significance Single submitter
- LINGO4 p.Arg477Trp Uncertain significance Single submitter
- LINGO4 p.Arg576Trp Uncertain significance Single submitter
- LINGO4 p.Arg587Gln Uncertain significance Single submitter
- LINGO4 p.Arg587Trp Uncertain significance Single submitter
- LINGO4 p.Arg82Cys Uncertain significance Single submitter
- LINGO4 p.Arg82His Uncertain significance Single submitter
- LINGO4 p.Asn263His Uncertain significance Single submitter
- LINGO4 p.Asn515Lys Uncertain significance Single submitter
- LINGO4 p.Asp215Asn Uncertain significance Single submitter
- LINGO4 p.Asp580Asn Uncertain significance Single submitter
- LINGO4 p.Cys31Tyr Uncertain significance Single submitter
- LINGO4 p.Cys364Gly Uncertain significance Single submitter
- LINGO4 p.Cys410Gly Uncertain significance Single submitter
- LINGO4 p.Cys484Gly Uncertain significance Single submitter
- LINGO4 p.Cys484Tyr Uncertain significance Single submitter
- LINGO4 p.Glu242Gln Uncertain significance Single submitter
- LINGO4 p.Glu340Gln Uncertain significance Single submitter
- LINGO4 p.Glu470Ala Uncertain significance Single submitter
- LINGO4 p.Gly28Asp Uncertain significance Single submitter
- LINGO4 p.Gly309Arg Uncertain significance Single submitter
- LINGO4 p.Gly579Arg Uncertain significance Single submitter
- LINGO4 p.Gly57Ala Uncertain significance Single submitter
- LINGO4 p.His321Tyr Uncertain significance Single submitter
- LINGO4 p.His390Asn Uncertain significance Single submitter
- LINGO4 p.His407Gln Uncertain significance Single submitter
- LINGO4 p.His451Arg Uncertain significance Single submitter
- LINGO4 p.Ile235Leu Uncertain significance Single submitter
- LINGO4 p.Ile288Asn Uncertain significance Single submitter
- LINGO4 p.Leu141Phe Uncertain significance Single submitter
- LINGO4 p.Leu187Val Uncertain significance Single submitter
- LINGO4 p.Leu22Val Uncertain significance Single submitter
- LINGO4 p.Leu237Phe Uncertain significance Single submitter
- LINGO4 p.Leu67Pro Uncertain significance Single submitter
- LINGO4 p.Lys559Thr Uncertain significance Single submitter
- LINGO4 p.Met123Ile Uncertain significance Single submitter
- LINGO4 p.Phe526Leu Uncertain significance Single submitter
- LINGO4 p.Phe540Cys Uncertain significance Single submitter
- LINGO4 p.Pro16Leu Uncertain significance Single submitter
- LINGO4 p.Pro246Arg Uncertain significance Single submitter
- LINGO4 p.Pro383Ser Uncertain significance Single submitter
- LINGO4 p.Ser157Gly Uncertain significance Single submitter
- LINGO4 p.Ser266Leu Uncertain significance Single submitter
- LINGO4 p.Ser314Phe Uncertain significance Single submitter
- LINGO4 p.Ser381Thr Uncertain significance Single submitter
- LINGO4 p.Ser418Leu Uncertain significance Single submitter
- LINGO4 p.Ser418Pro Uncertain significance Single submitter
- LINGO4 p.Ser529Asn Uncertain significance Single submitter
- LINGO4 p.Thr260Ser Uncertain significance Single submitter
- LINGO4 p.Trp73Leu Uncertain significance Single submitter
- LINGO4 p.Val163Ala Uncertain significance Single submitter
- LINGO4 p.Val163Ile Uncertain significance Single submitter
- LINGO4 p.Val300Ala Uncertain significance Single submitter
- LINGO4 p.Val474Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- LINGO4 p.Ala223Asp Uncertain significance Single submitter
- LINGO4 p.Ala223Thr Uncertain significance Single submitter
- LINGO4 p.Arg371Trp Uncertain significance Single submitter
- LINGO4 p.Arg374Cys Uncertain significance Single submitter
- LINGO4 p.Asn166Ser Uncertain significance Single submitter
- LINGO4 p.Gly226Glu Uncertain significance Single submitter
- LINGO4 p.Gly357Asp Uncertain significance Single submitter
- LINGO4 p.Gly428Asp Uncertain significance Single submitter
- LINGO4 p.Gly562Val Uncertain significance Single submitter
- LINGO4 p.Leu148Pro Uncertain significance Single submitter
- LINGO4 p.Leu51Val Uncertain significance Single submitter
- LINGO4 p.Lys591Asn Uncertain significance Single submitter
- LINGO4 p.Phe170Ser Uncertain significance Single submitter
- LINGO4 p.Pro173Leu Uncertain significance Single submitter
- LINGO4 p.Ser109Ile Uncertain significance Single submitter
- LINGO4 p.Thr545Pro Uncertain significance Single submitter
- LINGO4 p.Thr548Asn Uncertain significance Single submitter
All LINGO4 variants
Conflicting classifications of pathogenicity 1
- p.Ser284Phe Single submitter polymicrogyria ⚠
Likely benign 3
- p.Ala223= Single submitter
- p.Gln77Arg Single submitter
- p.Val518Met Single submitter
Uncertain significance 94
- p.Ala151Val Single submitter ⚠
- p.Ala223Asp Single submitter ⚠
- p.Ala223Thr Single submitter ⚠
- p.Ala319Thr Single submitter
- p.Ala335Thr Single submitter ⚠
- p.Ala431Val Single submitter ⚠
- p.Ala442Thr Single submitter ⚠
- p.Ala533Ser Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Arg189Gly Single submitter ⚠
- p.Arg189His Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg261Cys Single submitter ⚠
- p.Arg261His Single submitter ⚠
- p.Arg306Cys Single submitter
- p.Arg365Cys Single submitter ⚠
- p.Arg365His Single submitter ⚠
- p.Arg371Gln Single submitter ⚠
- p.Arg371Trp Single submitter ⚠
- p.Arg373Cys Single submitter
- p.Arg374Cys Single submitter ⚠
- p.Arg374His Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg416Gly Single submitter ⚠
- p.Arg421Gln Single submitter polymicrogyria ⚠
- p.Arg472His Single submitter ⚠
- p.Arg477Trp Single submitter ⚠
- p.Arg576Trp Single submitter ⚠
- p.Arg587Gln Single submitter ⚠
- p.Arg587Trp Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg82His Single submitter ⚠
- p.Asn166Ser Single submitter ⚠
- p.Asn263His Single submitter ⚠
- p.Asn515Lys Single submitter ⚠
- p.Asp215Asn Single submitter ⚠
- p.Asp580Asn Single submitter ⚠
- p.Cys31Tyr Single submitter ⚠
- p.Cys364Gly Single submitter ⚠
- p.Cys410Gly Single submitter ⚠
- p.Cys484Gly Single submitter ⚠
- p.Cys484Tyr Single submitter ⚠
- p.Glu242Gln Single submitter ⚠
- p.Glu340Gln Single submitter ⚠
- p.Glu470Ala Single submitter ⚠
- p.Gly226Glu Single submitter ⚠
- p.Gly28Asp Single submitter ⚠
- p.Gly309Arg Single submitter ⚠
- p.Gly357Asp Single submitter ⚠
- p.Gly428Asp Single submitter ⚠
- p.Gly562Val Single submitter ⚠
- p.Gly579Arg Single submitter ⚠
- p.Gly57Ala Single submitter ⚠
- p.His321Tyr Single submitter ⚠
- p.His390Asn Single submitter ⚠
- p.His407Gln Single submitter ⚠
- p.His451Arg Single submitter ⚠
- p.Ile235Leu Single submitter ⚠
- p.Ile288Asn Single submitter ⚠
- p.Leu141Phe Single submitter ⚠
- p.Leu148Pro Single submitter ⚠
- p.Leu187Val Single submitter ⚠
- p.Leu22Val Single submitter ⚠
- p.Leu237Phe Single submitter ⚠
- p.Leu51Val Single submitter ⚠
- p.Leu67Pro Single submitter ⚠
- p.Lys559Thr Single submitter ⚠
- p.Lys591Asn Single submitter ⚠
- p.Met123Ile Single submitter ⚠
- p.Phe170Ser Single submitter ⚠
- p.Phe526Leu Single submitter ⚠
- p.Phe540Cys Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro246Arg Single submitter ⚠
- p.Pro383Ser Single submitter ⚠
- p.Ser109Ile Single submitter ⚠
- p.Ser157Gly Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser314Phe Single submitter ⚠
- p.Ser381Thr Single submitter ⚠
- p.Ser418Leu Single submitter ⚠
- p.Ser418Pro Single submitter ⚠
- p.Ser529Asn Single submitter ⚠
- p.Thr260Ser Single submitter ⚠
- p.Thr545Pro Single submitter ⚠
- p.Thr548Asn Single submitter ⚠
- p.Trp73Leu Single submitter ⚠
- p.Val163Ala Single submitter ⚠
- p.Val163Gly Single submitter
- p.Val163Ile Single submitter ⚠
- p.Val300Ala Single submitter ⚠
- p.Val474Leu Single submitter ⚠