LNPEP — 119 ClinVar variants
All ClinVar germline LNPEP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
3 Likely benign · 116 Uncertain significance
Full LNPEP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 87
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LNPEP p.Ala298Thr Uncertain significance Single submitter
- LNPEP p.Ala298Val Uncertain significance Single submitter
- LNPEP p.Arg439Gln Uncertain significance Single submitter
- LNPEP p.Arg49Gln Uncertain significance Single submitter
- LNPEP p.Arg515Gln Uncertain significance Single submitter
- LNPEP p.Arg634Gly Uncertain significance Single submitter
- LNPEP p.Arg634Ser Uncertain significance Single submitter
- LNPEP p.Arg663Gly Uncertain significance Single submitter
- LNPEP p.Arg663Lys Uncertain significance Single submitter
- LNPEP p.Arg89Gln Uncertain significance Single submitter
- LNPEP p.Arg8Gln Uncertain significance Single submitter
- LNPEP p.Arg904Gln Uncertain significance Single submitter
- LNPEP p.Arg920Gln Uncertain significance Single submitter
- LNPEP p.Arg996Gly Uncertain significance Single submitter
- LNPEP p.Asn145Thr Uncertain significance Single submitter
- LNPEP p.Asn215Tyr Uncertain significance Single submitter
- LNPEP p.Asn256Ile Uncertain significance Single submitter
- LNPEP p.Asn432Ser Uncertain significance Single submitter
- LNPEP p.Asn682Ser Uncertain significance Single submitter
- LNPEP p.Asn730His Uncertain significance Single submitter
- LNPEP p.Asn730Thr Uncertain significance Single submitter
- LNPEP p.Asn734Thr Uncertain significance Single submitter
- LNPEP p.Asn758Thr Uncertain significance Single submitter
- LNPEP p.Asp100Val Uncertain significance Single submitter
- LNPEP p.Asp513Gly Uncertain significance Single submitter
- LNPEP p.Asp786Asn Uncertain significance Single submitter
- LNPEP p.Asp871Val Uncertain significance Single submitter
- LNPEP p.Asp943Glu Uncertain significance Single submitter
- LNPEP p.Cys35Tyr Uncertain significance Single submitter
- LNPEP p.Cys999Trp Uncertain significance Single submitter
- LNPEP p.Gln806Leu Uncertain significance Single submitter
- LNPEP p.Gly140Val Uncertain significance Single submitter
- LNPEP p.His391Arg Uncertain significance Single submitter
- LNPEP p.His653Leu Uncertain significance Single submitter
- LNPEP p.Ile148Thr Uncertain significance Single submitter
- LNPEP p.Ile267Val Uncertain significance Single submitter
- LNPEP p.Ile701Thr Uncertain significance Single submitter
- LNPEP p.Ile701Val Uncertain significance Single submitter
- LNPEP p.Ile735Val Uncertain significance Single submitter
- LNPEP p.Ile884Val Uncertain significance Single submitter
- LNPEP p.Ile893Met Uncertain significance Single submitter
- LNPEP p.Ile928Val Uncertain significance Single submitter
- LNPEP p.Leu369Gln Uncertain significance Single submitter
- LNPEP p.Leu419Val Uncertain significance Single submitter
- LNPEP p.Leu547Phe Uncertain significance Single submitter
- LNPEP p.Leu612Arg Uncertain significance Single submitter
- LNPEP p.Leu683Val Uncertain significance Single submitter
- LNPEP p.Leu940Pro Uncertain significance Single submitter
- LNPEP p.Lys1016Arg Uncertain significance Single submitter
- LNPEP p.Lys1019Arg Uncertain significance Single submitter
- LNPEP p.Lys1019Glu Uncertain significance Single submitter
- LNPEP p.Lys367Glu Uncertain significance Single submitter
- LNPEP p.Lys951Glu Uncertain significance Single submitter
- LNPEP p.Met126Ile Uncertain significance Single submitter
- LNPEP p.Met606Leu Uncertain significance Single submitter
- LNPEP p.Met63Ile Uncertain significance Single submitter
- LNPEP p.Met860Val Uncertain significance Single submitter
- LNPEP p.Phe919Leu Uncertain significance Single submitter
- LNPEP p.Phe935Ser Uncertain significance Single submitter
- LNPEP p.Pro641Arg Uncertain significance Single submitter
- LNPEP p.Pro641Leu Uncertain significance Single submitter
- LNPEP p.Pro745Leu Uncertain significance Single submitter
- LNPEP p.Pro936Ser Uncertain significance Single submitter
- LNPEP p.Pro99Ser Uncertain significance Single submitter
- LNPEP p.Ser123Phe Uncertain significance Single submitter
- LNPEP p.Ser187Leu Uncertain significance Single submitter
- LNPEP p.Ser269Gly Uncertain significance Single submitter
- LNPEP p.Ser355Asn Uncertain significance Single submitter
- LNPEP p.Ser564Gly Uncertain significance Single submitter
- LNPEP p.Ser849Tyr Uncertain significance Single submitter
- LNPEP p.Thr258Lys Uncertain significance Single submitter
- LNPEP p.Thr609Asn Uncertain significance Single submitter
- LNPEP p.Thr807Ile Uncertain significance Single submitter
- LNPEP p.Thr971Ala Uncertain significance Single submitter
- LNPEP p.Tyr271Ser Uncertain significance Single submitter
- LNPEP p.Tyr46Cys Uncertain significance Single submitter
- LNPEP p.Tyr549Phe Uncertain significance Single submitter
- LNPEP p.Tyr70Cys Uncertain significance Single submitter
- LNPEP p.Tyr776Cys Uncertain significance Single submitter
- LNPEP p.Val113Ile Uncertain significance Single submitter
- LNPEP p.Val198Ile Uncertain significance Single submitter
- LNPEP p.Val219Ala Uncertain significance Single submitter
- LNPEP p.Val246Ile Uncertain significance Single submitter
- LNPEP p.Val373Leu Uncertain significance Single submitter
- LNPEP p.Val572Leu Uncertain significance Single submitter
- LNPEP p.Val744Leu Uncertain significance Single submitter
- LNPEP p.Val792Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- LNPEP p.Ala467Thr Uncertain significance Single submitter
- LNPEP p.Arg817Gln Uncertain significance Single submitter
- LNPEP p.Arg996Trp Uncertain significance Single submitter
- LNPEP p.Asp29Glu Uncertain significance Single submitter
- LNPEP p.Asp588Gly Uncertain significance Single submitter
- LNPEP p.Glu347Lys Uncertain significance Single submitter
- LNPEP p.Gly78Asp Uncertain significance Single submitter
- LNPEP p.Gly959Arg Uncertain significance Single submitter
- LNPEP p.Ile681Thr Uncertain significance Single submitter
- LNPEP p.Leu1025Arg Uncertain significance Single submitter
- LNPEP p.Leu419Phe Uncertain significance Single submitter
- LNPEP p.Phe404Leu Uncertain significance Single submitter
- LNPEP p.Phe516Cys Uncertain significance Single submitter
- LNPEP p.Pro856Arg Uncertain significance Single submitter
- LNPEP p.Ser583Pro Uncertain significance Single submitter
- LNPEP p.Ser592Arg Uncertain significance Single submitter
- LNPEP p.Thr976Ala Uncertain significance Single submitter
All LNPEP variants
Likely benign 3
- p.Asn831Ser Single submitter
- p.Val338Ile Single submitter
- p.Val690Ile Single submitter
Uncertain significance 116
- p.Ala298Thr Single submitter ⚠
- p.Ala298Val Single submitter ⚠
- p.Ala393Val Single submitter
- p.Ala467Thr Single submitter ⚠
- p.Arg439Gln Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg515Gln Single submitter ⚠
- p.Arg52Gln Single submitter
- p.Arg634Gly Single submitter ⚠
- p.Arg634Ser Single submitter ⚠
- p.Arg663Gly Single submitter ⚠
- p.Arg663Lys Single submitter ⚠
- p.Arg817Gln Single submitter ⚠
- p.Arg89Gln Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Arg904Gln Single submitter ⚠
- p.Arg920Gln Single submitter ⚠
- p.Arg996Gly Single submitter ⚠
- p.Arg996Trp Single submitter ⚠
- p.Asn145Thr Single submitter ⚠
- p.Asn215Tyr Single submitter ⚠
- p.Asn256Ile Single submitter ⚠
- p.Asn432Ser Single submitter ⚠
- p.Asn682Ser Single submitter ⚠
- p.Asn730His Single submitter ⚠
- p.Asn730Thr Single submitter ⚠
- p.Asn734Thr Single submitter ⚠
- p.Asn758Thr Single submitter ⚠
- p.Asp100Val Single submitter ⚠
- p.Asp29Glu Single submitter ⚠
- p.Asp513Gly Single submitter ⚠
- p.Asp588Gly Single submitter ⚠
- p.Asp69Asn Single submitter
- p.Asp786Asn Single submitter ⚠
- p.Asp871Val Single submitter ⚠
- p.Asp943Glu Single submitter ⚠
- p.Cys141Phe Single submitter
- p.Cys35Tyr Single submitter ⚠
- p.Cys999Trp Single submitter ⚠
- p.Gln806Leu Single submitter ⚠
- p.Glu347Lys Single submitter ⚠
- p.Gly140Arg Single submitter
- p.Gly140Val Single submitter ⚠
- p.Gly552Ala Single submitter
- p.Gly78Asp Single submitter ⚠
- p.Gly959Arg Single submitter ⚠
- p.His391Arg Single submitter ⚠
- p.His653Leu Single submitter ⚠
- p.Ile148Thr Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile681Thr Single submitter ⚠
- p.Ile701Thr Single submitter ⚠
- p.Ile701Val Single submitter ⚠
- p.Ile735Val Single submitter ⚠
- p.Ile884Val Single submitter ⚠
- p.Ile893Met Single submitter ⚠
- p.Ile928Val Single submitter ⚠
- p.Leu1025Arg Single submitter ⚠
- p.Leu369Gln Single submitter ⚠
- p.Leu419Phe Single submitter ⚠
- p.Leu419Val Single submitter ⚠
- p.Leu547Phe Single submitter ⚠
- p.Leu612Arg Single submitter ⚠
- p.Leu683Val Single submitter ⚠
- p.Leu855Pro Single submitter
- p.Leu940Pro Single submitter ⚠
- p.Lys1016Arg Single submitter ⚠
- p.Lys1019Arg Single submitter ⚠
- p.Lys1019Glu Single submitter ⚠
- p.Lys367Glu Single submitter ⚠
- p.Lys951Glu Single submitter ⚠
- p.Met126Ile Single submitter ⚠
- p.Met606Leu Single submitter ⚠
- p.Met63Ile Single submitter ⚠
- p.Met860Val Single submitter ⚠
- p.Phe404Leu Single submitter ⚠
- p.Phe516Cys Single submitter ⚠
- p.Phe919Leu Single submitter ⚠
- p.Phe935Ser Single submitter ⚠
- p.Pro641Arg Single submitter ⚠
- p.Pro641Leu Single submitter ⚠
- p.Pro655fs Single submitter
- p.Pro745Leu Single submitter ⚠
- p.Pro856Arg Single submitter ⚠
- p.Pro936Ser Single submitter ⚠
- p.Pro99Ser Single submitter ⚠
- p.Ser123Phe Single submitter ⚠
- p.Ser187Leu Single submitter ⚠
- p.Ser269Gly Single submitter ⚠
- p.Ser355Asn Single submitter ⚠
- p.Ser564Gly Single submitter ⚠
- p.Ser583Pro Single submitter ⚠
- p.Ser592Arg Single submitter ⚠
- p.Ser849Tyr Single submitter ⚠
- p.Thr258Lys Single submitter ⚠
- p.Thr609Asn Single submitter ⚠
- p.Thr807Ile Single submitter ⚠
- p.Thr971Ala Single submitter ⚠
- p.Thr976Ala Single submitter ⚠
- p.Trp652Ter Single submitter
- p.Trp908Ter Single submitter
- p.Tyr271Ser Single submitter ⚠
- p.Tyr46Cys Single submitter ⚠
- p.Tyr549Phe Single submitter ⚠
- p.Tyr70Cys Single submitter ⚠
- p.Tyr776Cys Single submitter ⚠
- p.Val113Ile Single submitter ⚠
- p.Val198Ile Single submitter ⚠
- p.Val219Ala Single submitter ⚠
- p.Val246Ile Single submitter ⚠
- p.Val373Leu Single submitter ⚠
- p.Val572fs Single submitter
- p.Val572Leu Single submitter ⚠
- p.Val744Leu Single submitter ⚠
- p.Val792Leu Single submitter ⚠
- p.Val983Phe Single submitter