Sugi Variant

Sugi Variant/LONP1

LONP1 — 1085 ClinVar variants

All ClinVar germline LONP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 427 flagged for review →

11 Pathogenic · 14 Likely pathogenic · 89 Conflicting · 78 Benign · 29 Benign/Likely benign · 492 Likely benign · 372 Uncertain significance

Full LONP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 427

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 59

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 252

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 252

Predictors split 115

The independent predictors disagree with each other — read with care.

All LONP1 variants

Pathogenic 11

Likely pathogenic 14

Conflicting classifications of pathogenicity 89

Benign 78

Benign/Likely benign 29

Likely benign 492

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 372

Showing the top 300 by review status; the full set is in the sitemap.