LPAR1 — 40 ClinVar variants
All ClinVar germline LPAR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Benign · 1 Likely benign · 38 Uncertain significance
Full LPAR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPAR1 p.Ala2Asp Uncertain significance Single submitter
- LPAR1 p.Ala42Thr Uncertain significance Single submitter
- LPAR1 p.Arg158Gln Uncertain significance Single submitter
- LPAR1 p.Arg330His Uncertain significance Single submitter
- LPAR1 p.Arg330Leu Uncertain significance Single submitter
- LPAR1 p.Arg343His Uncertain significance Single submitter
- LPAR1 p.Arg78Cys Uncertain significance Single submitter
- LPAR1 p.Asn112Asp Uncertain significance Single submitter
- LPAR1 p.Asn20Ser Uncertain significance Single submitter
- LPAR1 p.Cys24Ser Uncertain significance Single submitter
- LPAR1 p.Cys60Arg Uncertain significance Single submitter
- LPAR1 p.Glu28Lys Uncertain significance Single submitter
- LPAR1 p.Gly336Ser Uncertain significance Single submitter
- LPAR1 p.Gly340Asp Uncertain significance Single submitter
- LPAR1 p.His40Arg Uncertain significance Single submitter
- LPAR1 p.His81Tyr Uncertain significance Single submitter
- LPAR1 p.Ile352Leu Uncertain significance Single submitter
- LPAR1 p.Ile61Val Uncertain significance Single submitter
- LPAR1 p.Met174Val Uncertain significance Single submitter
- LPAR1 p.Ser244Thr Uncertain significance Single submitter
- LPAR1 p.Ser344Leu Uncertain significance Single submitter
- LPAR1 p.Ser5Pro Uncertain significance Single submitter
- LPAR1 p.Thr43Arg Uncertain significance Single submitter
- LPAR1 p.Thr47Ala Uncertain significance Single submitter
- LPAR1 p.Val136Ala Uncertain significance Single submitter
- LPAR1 p.Val165Leu Uncertain significance Single submitter
- LPAR1 p.Val170Ala Uncertain significance Single submitter
- LPAR1 p.Val177Ile Uncertain significance Single submitter
- LPAR1 p.Val216Ala Uncertain significance Single submitter
- LPAR1 p.Val261Ile Uncertain significance Single submitter
- LPAR1 p.Val282Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- LPAR1 p.Ala305Val Uncertain significance Single submitter
- LPAR1 p.Arg250Trp Uncertain significance Single submitter
- LPAR1 p.Met106Thr Uncertain significance Single submitter
- LPAR1 p.Met178Thr Uncertain significance Single submitter
- LPAR1 p.Ser37Asn Uncertain significance Single submitter
- LPAR1 p.Thr133Met Uncertain significance Single submitter
All LPAR1 variants
Benign 1
- p.Glu145= Multiple submitters
Likely benign 1
- p.Arg152Cys No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 38
- p.Ala2Asp Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala42Thr Single submitter ⚠
- p.Arg158Gln Single submitter ⚠
- p.Arg250Trp Single submitter ⚠
- p.Arg330His Single submitter ⚠
- p.Arg330Leu Single submitter ⚠
- p.Arg343His Single submitter ⚠
- p.Arg78Cys Single submitter ⚠
- p.Asn112Asp Single submitter ⚠
- p.Asn20Ser Single submitter ⚠
- p.Cys24Ser Single submitter ⚠
- p.Cys60Arg Single submitter ⚠
- p.Glu28Lys Single submitter ⚠
- p.Gly336Ser Single submitter ⚠
- p.Gly340Asp Single submitter ⚠
- p.His40Arg Single submitter ⚠
- p.His81Tyr Single submitter ⚠
- p.Ile352Leu Single submitter ⚠
- p.Ile61Val Single submitter ⚠
- p.Met106Thr Single submitter ⚠
- p.Met174Val Single submitter ⚠
- p.Met178Thr Single submitter ⚠
- p.Ser244Phe Single submitter
- p.Ser244Thr Single submitter ⚠
- p.Ser344Leu Single submitter ⚠
- p.Ser37Asn Single submitter ⚠
- p.Ser5Pro Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr43Arg Single submitter ⚠
- p.Thr47Ala Single submitter ⚠
- p.Val136Ala Single submitter ⚠
- p.Val165Leu Single submitter ⚠
- p.Val170Ala Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val216Ala Single submitter ⚠
- p.Val261Ile Single submitter ⚠
- p.Val282Ala Single submitter ⚠