LPAR2 — 44 ClinVar variants
All ClinVar germline LPAR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Benign · 43 Uncertain significance
Full LPAR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPAR2 c.-1C>G Uncertain significance Single submitter
- LPAR2 p.Ala171Val Uncertain significance Single submitter
- LPAR2 p.Ala310Thr Uncertain significance Single submitter
- LPAR2 p.Ala55Val Uncertain significance Single submitter
- LPAR2 p.Ala94Ser Uncertain significance Single submitter
- LPAR2 p.Arg128Cys Uncertain significance Single submitter
- LPAR2 p.Arg141His Uncertain significance Single submitter
- LPAR2 p.Arg174His Uncertain significance Single submitter
- LPAR2 p.Arg177His Uncertain significance Single submitter
- LPAR2 p.Arg207His Uncertain significance Single submitter
- LPAR2 p.Arg213Leu Uncertain significance Single submitter
- LPAR2 p.Arg214Leu Uncertain significance Single submitter
- LPAR2 p.Arg228His Uncertain significance Single submitter
- LPAR2 p.Arg230Gln Uncertain significance Single submitter
- LPAR2 p.Arg295Gln Uncertain significance Single submitter
- LPAR2 p.Arg304His Uncertain significance Single submitter
- LPAR2 p.Arg317Cys Uncertain significance Single submitter
- LPAR2 p.Glu318Lys Uncertain significance Single submitter
- LPAR2 p.Glu338Asp Uncertain significance Single submitter
- LPAR2 p.His321Tyr Uncertain significance Single submitter
- LPAR2 p.His341Tyr Uncertain significance Single submitter
- LPAR2 p.Pro140Leu Uncertain significance Single submitter
- LPAR2 p.Thr332Ala Uncertain significance Single submitter
- LPAR2 p.Tyr205Asp Uncertain significance Single submitter
- LPAR2 p.Val133Met Uncertain significance Single submitter
- LPAR2 p.Val189Ile Uncertain significance Single submitter
- LPAR2 p.Val223Gly Uncertain significance Single submitter
- LPAR2 p.Val41Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- LPAR2 p.Ala188Val Uncertain significance Single submitter
- LPAR2 p.Ala55Pro Uncertain significance Single submitter
- LPAR2 p.Arg174Cys Uncertain significance Single submitter
- LPAR2 p.Phe102Leu Uncertain significance Single submitter
- LPAR2 p.Ser183Asn Uncertain significance Single submitter
- LPAR2 p.Thr206Asn Uncertain significance Single submitter
All LPAR2 variants
Benign 1
- c.531C>T Multiple submitters
Uncertain significance 43
- c.-1C>G Single submitter ⚠
- p.Ala171Val Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala310Thr Single submitter ⚠
- p.Ala55Pro Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Ala94Ser Single submitter ⚠
- p.Arg128Cys Single submitter ⚠
- p.Arg141His Single submitter ⚠
- p.Arg174Cys Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg177His Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg213Leu Single submitter ⚠
- p.Arg214Leu Single submitter ⚠
- p.Arg218His Single submitter
- p.Arg228His Single submitter ⚠
- p.Arg230Gln Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg300Cys Single submitter
- p.Arg300His Single submitter
- p.Arg304His Single submitter ⚠
- p.Arg317Cys Single submitter ⚠
- p.Glu282Lys Single submitter
- p.Glu318Lys Single submitter ⚠
- p.Glu338Asp Single submitter ⚠
- p.His136Arg Single submitter
- p.His321Tyr Single submitter ⚠
- p.His341Tyr Single submitter ⚠
- p.Ile122Val Single submitter
- p.Leu76Arg Single submitter
- p.Phe102Leu Single submitter ⚠
- p.Phe198Leu Single submitter
- p.Pro140Leu Single submitter ⚠
- p.Ser183Asn Single submitter ⚠
- p.Thr206Asn Single submitter ⚠
- p.Thr332Ala Single submitter ⚠
- p.Tyr205Asp Single submitter ⚠
- p.Val133Met Single submitter ⚠
- p.Val151Met Single submitter
- p.Val189Ile Single submitter ⚠
- p.Val223Gly Single submitter ⚠
- p.Val41Leu Single submitter ⚠