LPAR3 — 64 ClinVar variants
All ClinVar germline LPAR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
3 Benign · 61 Uncertain significance
Full LPAR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPAR3 p.Ala53Thr Uncertain significance Single submitter
- LPAR3 p.Ala53Val Uncertain significance Single submitter
- LPAR3 p.Arg101His Uncertain significance Single submitter
- LPAR3 p.Arg101Ser Uncertain significance Single submitter
- LPAR3 p.Arg105Cys Uncertain significance Single submitter
- LPAR3 p.Arg105His Uncertain significance Single submitter
- LPAR3 p.Arg135Gln Uncertain significance Single submitter
- LPAR3 p.Arg16Gly Uncertain significance Single submitter
- LPAR3 p.Arg208Gln Uncertain significance Single submitter
- LPAR3 p.Arg319Cys Uncertain significance Single submitter
- LPAR3 p.Asp76Asn Uncertain significance Single submitter
- LPAR3 p.Cys169Trp Uncertain significance Single submitter
- LPAR3 p.Cys176Phe Uncertain significance Single submitter
- LPAR3 p.Gln336Arg Uncertain significance Single submitter
- LPAR3 p.Glu298Lys Uncertain significance Single submitter
- LPAR3 p.Glu317Lys Uncertain significance Single submitter
- LPAR3 p.Gly263Arg Uncertain significance Single submitter
- LPAR3 p.Gly345Asp Uncertain significance Single submitter
- LPAR3 p.Gly345Ser Uncertain significance Single submitter
- LPAR3 p.Ile131Val Uncertain significance Single submitter
- LPAR3 p.Ile173Val Uncertain significance Single submitter
- LPAR3 p.Ile182Val Uncertain significance Single submitter
- LPAR3 p.Leu165Arg Uncertain significance Single submitter
- LPAR3 p.Met307Leu Uncertain significance Single submitter
- LPAR3 p.Phe248Cys Uncertain significance Single submitter
- LPAR3 p.Phe311Leu Uncertain significance Single submitter
- LPAR3 p.Pro163Leu Uncertain significance Single submitter
- LPAR3 p.Pro254Leu Uncertain significance Single submitter
- LPAR3 p.Pro324Thr Uncertain significance Single submitter
- LPAR3 p.Ser225Cys Uncertain significance Single submitter
- LPAR3 p.Thr164Ala Uncertain significance Single submitter
- LPAR3 p.Thr164Ile Uncertain significance Single submitter
- LPAR3 p.Thr217Asn Uncertain significance Single submitter
- LPAR3 p.Thr240Met Uncertain significance Single submitter
- LPAR3 p.Thr96Ile Uncertain significance Single submitter
- LPAR3 p.Tyr210His Uncertain significance Single submitter
- LPAR3 p.Tyr295Cys Uncertain significance Single submitter
- LPAR3 p.Tyr83Asn Uncertain significance Single submitter
- LPAR3 p.Tyr83Cys Uncertain significance Single submitter
- LPAR3 p.Val125Gly Uncertain significance Single submitter
- LPAR3 p.Val125Leu Uncertain significance Single submitter
- LPAR3 p.Val125Met Uncertain significance Single submitter
- LPAR3 p.Val136Phe Uncertain significance Single submitter
- LPAR3 p.Val189Phe Uncertain significance Single submitter
- LPAR3 p.Val193Ala Uncertain significance Single submitter
- LPAR3 p.Val287Ile Uncertain significance Single submitter
- LPAR3 p.Val31Leu Uncertain significance Single submitter
- LPAR3 p.Val33Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- LPAR3 p.Ala54Thr Uncertain significance Single submitter
- LPAR3 p.Arg144Ser Uncertain significance Single submitter
- LPAR3 p.Arg208Gly Uncertain significance Single submitter
- LPAR3 p.Asn58Thr Uncertain significance Single submitter
- LPAR3 p.Asp299His Uncertain significance Single submitter
- LPAR3 p.His137Arg Uncertain significance Single submitter
- LPAR3 p.Lys57Asn Uncertain significance Single submitter
- LPAR3 p.Met300Ile Uncertain significance Single submitter
- LPAR3 p.Phe78Leu Uncertain significance Single submitter
- LPAR3 p.Pro234Thr Uncertain significance Single submitter
- LPAR3 p.Pro64Ala Uncertain significance Single submitter
- LPAR3 p.Trp25Arg Uncertain significance Single submitter
All LPAR3 variants
Benign 3
- p.Lys275= Multiple submitters
- p.Thr114= Multiple submitters
- p.Val288Met Multiple submitters
Uncertain significance 61
- p.Ala53Thr Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Arg101His Single submitter ⚠
- p.Arg101Ser Single submitter ⚠
- p.Arg105Cys Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg144Ser Single submitter ⚠
- p.Arg16Gly Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg208Gly Single submitter ⚠
- p.Arg231Trp Single submitter
- p.Arg319Cys Single submitter ⚠
- p.Asn58Thr Single submitter ⚠
- p.Asp299His Single submitter ⚠
- p.Asp76Asn Single submitter ⚠
- p.Cys169Trp Single submitter ⚠
- p.Cys176Phe Single submitter ⚠
- p.Gln336Arg Single submitter ⚠
- p.Glu298Lys Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Gly263Arg Single submitter ⚠
- p.Gly345Asp Single submitter ⚠
- p.Gly345Ser Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile173Val Single submitter ⚠
- p.Ile182Val Single submitter ⚠
- p.Leu165Arg Single submitter ⚠
- p.Lys57Asn Single submitter ⚠
- p.Met300Ile Single submitter ⚠
- p.Met307Leu Single submitter ⚠
- p.Phe248Cys Single submitter ⚠
- p.Phe311Leu Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro234Thr Single submitter ⚠
- p.Pro254Leu Single submitter ⚠
- p.Pro324Thr Single submitter ⚠
- p.Pro64Ala Single submitter ⚠
- p.Ser225Cys Single submitter ⚠
- p.Thr164Ala Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Thr217Asn Single submitter ⚠
- p.Thr240Met Single submitter ⚠
- p.Thr96Ile Single submitter ⚠
- p.Trp25Arg Single submitter ⚠
- p.Tyr210His Single submitter ⚠
- p.Tyr295Cys Single submitter ⚠
- p.Tyr83Asn Single submitter ⚠
- p.Tyr83Cys Single submitter ⚠
- p.Val125Gly Single submitter ⚠
- p.Val125Leu Single submitter ⚠
- p.Val125Met Single submitter ⚠
- p.Val136Phe Single submitter ⚠
- p.Val189Phe Single submitter ⚠
- p.Val193Ala Single submitter ⚠
- p.Val287Ile Single submitter ⚠
- p.Val31Leu Single submitter ⚠
- p.Val33Ile Single submitter ⚠