LPAR4 — 34 ClinVar variants
All ClinVar germline LPAR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 1 Likely benign · 32 Uncertain significance
Full LPAR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPAR4 p.Arg195His Uncertain significance Single submitter
- LPAR4 p.Arg232Cys Uncertain significance Single submitter
- LPAR4 p.Arg67His Uncertain significance Single submitter
- LPAR4 p.Asn101Ser Uncertain significance Single submitter
- LPAR4 p.Asn80Ser Uncertain significance Single submitter
- LPAR4 p.Asp135Val Uncertain significance Single submitter
- LPAR4 p.Asp13His Uncertain significance Single submitter
- LPAR4 p.Cys159Arg Uncertain significance Single submitter
- LPAR4 p.Glu331Asp Uncertain significance Single submitter
- LPAR4 p.Gly2Ser Uncertain significance Single submitter
- LPAR4 p.Ile157Val Uncertain significance Single submitter
- LPAR4 p.Ile218Thr Uncertain significance Single submitter
- LPAR4 p.Ile328Asn Uncertain significance Single submitter
- LPAR4 p.Leu248Val Uncertain significance Single submitter
- LPAR4 p.Leu315Phe Uncertain significance Single submitter
- LPAR4 p.Leu86Val Uncertain significance Single submitter
- LPAR4 p.Met365Thr Uncertain significance Single submitter
- LPAR4 p.Phe62Ser Uncertain significance Single submitter
- LPAR4 p.Phe66Cys Uncertain significance Single submitter
- LPAR4 p.Phe94Cys Uncertain significance Single submitter
- LPAR4 p.Ser155Tyr Uncertain significance Single submitter
- LPAR4 p.Thr185Asn Uncertain significance Single submitter
- LPAR4 p.Thr199Ser Uncertain significance Single submitter
- LPAR4 p.Thr236Ile Uncertain significance Single submitter
- LPAR4 p.Trp197Arg Uncertain significance Single submitter
- LPAR4 p.Tyr311Asn Uncertain significance Single submitter
- LPAR4 p.Val226Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All LPAR4 variants
Benign 1
- p.Leu54Met Single submitter
Likely benign 1
- p.Val45Ile Single submitter
Uncertain significance 32
- p.Arg147His Single submitter ⚠
- p.Arg195His Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg67His Single submitter ⚠
- p.Asn101Ser Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Asp135Val Single submitter ⚠
- p.Asp13His Single submitter ⚠
- p.Cys159Arg Single submitter ⚠
- p.Glu286Gly Single submitter ⚠
- p.Glu331Asp Single submitter ⚠
- p.Gly191Ala Single submitter ⚠
- p.Gly2Ser Single submitter ⚠
- p.Ile157Val Single submitter ⚠
- p.Ile218Thr Single submitter ⚠
- p.Ile328Asn Single submitter ⚠
- p.Leu248Val Single submitter ⚠
- p.Leu315Phe Single submitter ⚠
- p.Leu86Val Single submitter ⚠
- p.Met365Thr Single submitter ⚠
- p.Phe334Leu Single submitter
- p.Phe62Ser Single submitter ⚠
- p.Phe66Cys Single submitter ⚠
- p.Phe94Cys Single submitter ⚠
- p.Ser155Tyr Single submitter ⚠
- p.Ser277Tyr Single submitter ⚠
- p.Thr185Asn Single submitter ⚠
- p.Thr199Ser Single submitter ⚠
- p.Thr236Ile Single submitter ⚠
- p.Trp197Arg Single submitter ⚠
- p.Tyr311Asn Single submitter ⚠
- p.Val226Ala Single submitter ⚠