LPAR5 — 62 ClinVar variants
All ClinVar germline LPAR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
62 Uncertain significance
Full LPAR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPAR5 p.Ala138Val Uncertain significance Single submitter
- LPAR5 p.Ala153Thr Uncertain significance Single submitter
- LPAR5 p.Ala223Pro Uncertain significance Single submitter
- LPAR5 p.Ala238Thr Uncertain significance Single submitter
- LPAR5 p.Ala267Thr Uncertain significance Single submitter
- LPAR5 p.Arg136His Uncertain significance Single submitter
- LPAR5 p.Arg139Gln Uncertain significance Single submitter
- LPAR5 p.Arg161Thr Uncertain significance Single submitter
- LPAR5 p.Arg187Thr Uncertain significance Single submitter
- LPAR5 p.Arg220His Uncertain significance Single submitter
- LPAR5 p.Arg23His Uncertain significance Single submitter
- LPAR5 p.Arg326Trp Uncertain significance Single submitter
- LPAR5 p.Arg49Ser Uncertain significance Single submitter
- LPAR5 p.Gln225Glu Uncertain significance Single submitter
- LPAR5 p.Gln365His Uncertain significance Single submitter
- LPAR5 p.Glu302Gln Uncertain significance Single submitter
- LPAR5 p.Glu302Lys Uncertain significance Single submitter
- LPAR5 p.Gly212Val Uncertain significance Single submitter
- LPAR5 p.Gly277Arg Uncertain significance Single submitter
- LPAR5 p.Gly277Glu Uncertain significance Single submitter
- LPAR5 p.His125Asp Uncertain significance Single submitter
- LPAR5 p.His358Leu Uncertain significance Single submitter
- LPAR5 p.Leu191Val Uncertain significance Single submitter
- LPAR5 p.Leu198Val Uncertain significance Single submitter
- LPAR5 p.Leu202Gln Uncertain significance Single submitter
- LPAR5 p.Leu244Val Uncertain significance Single submitter
- LPAR5 p.Leu329Val Uncertain significance Single submitter
- LPAR5 p.Met105Leu Uncertain significance Single submitter
- LPAR5 p.Pro16Ala Uncertain significance Single submitter
- LPAR5 p.Pro249Ser Uncertain significance Single submitter
- LPAR5 p.Pro270Leu Uncertain significance Single submitter
- LPAR5 p.Ser163Trp Uncertain significance Single submitter
- LPAR5 p.Ser58Asn Uncertain significance Single submitter
- LPAR5 p.Thr232Ser Uncertain significance Single submitter
- LPAR5 p.Thr313Ala Uncertain significance Single submitter
- LPAR5 p.Thr8Asn Uncertain significance Single submitter
- LPAR5 p.Thr96Met Uncertain significance Single submitter
- LPAR5 p.Trp216Arg Uncertain significance Single submitter
- LPAR5 p.Val12Leu Uncertain significance Single submitter
- LPAR5 p.Val137Met Uncertain significance Single submitter
- LPAR5 p.Val151Leu Uncertain significance Single submitter
- LPAR5 p.Val233Met Uncertain significance Single submitter
- LPAR5 p.Val241Asp Uncertain significance Single submitter
- LPAR5 p.Val269Leu Uncertain significance Single submitter
- LPAR5 p.Val269Met Uncertain significance Single submitter
- LPAR5 p.Val275Leu Uncertain significance Single submitter
- LPAR5 p.Val28Ile Uncertain significance Single submitter
- LPAR5 p.Val56Met Uncertain significance Single submitter
- LPAR5 p.Val57Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- LPAR5 p.Arg134Trp Uncertain significance Single submitter
- LPAR5 p.Arg229Leu Uncertain significance Single submitter
- LPAR5 p.Arg52Ser Uncertain significance Single submitter
- LPAR5 p.Asp17His Uncertain significance Single submitter
- LPAR5 p.Glu177Gly Uncertain significance Single submitter
- LPAR5 p.Met282Ile Uncertain significance Single submitter
- LPAR5 p.Phe47Leu Uncertain significance Single submitter
- LPAR5 p.Trp184Arg Uncertain significance Single submitter
- LPAR5 p.Val57Leu Uncertain significance Single submitter
- LPAR5 p.Val59Met Uncertain significance Single submitter
All LPAR5 variants
Uncertain significance 62
- p.Ala138Thr Single submitter
- p.Ala138Val Single submitter ⚠
- p.Ala153Thr Single submitter ⚠
- p.Ala223Pro Single submitter ⚠
- p.Ala238Thr Single submitter ⚠
- p.Ala267Thr Single submitter ⚠
- p.Arg134Trp Single submitter ⚠
- p.Arg136His Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.Arg161Thr Single submitter ⚠
- p.Arg187Thr Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg229Leu Single submitter ⚠
- p.Arg23His Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg49Ser Single submitter ⚠
- p.Arg52Ser Single submitter ⚠
- p.Asp17His Single submitter ⚠
- p.Gln225Glu Single submitter ⚠
- p.Gln365His Single submitter ⚠
- p.Glu177Gly Single submitter ⚠
- p.Glu302Gln Single submitter ⚠
- p.Glu302Lys Single submitter ⚠
- p.Gly212Arg Single submitter
- p.Gly212Val Single submitter ⚠
- p.Gly277Arg Single submitter ⚠
- p.Gly277Glu Single submitter ⚠
- p.His125Asp Single submitter ⚠
- p.His160Tyr Single submitter
- p.His358Leu Single submitter ⚠
- p.Leu191Val Single submitter ⚠
- p.Leu198Val Single submitter ⚠
- p.Leu202Gln Single submitter ⚠
- p.Leu244Val Single submitter ⚠
- p.Leu329Val Single submitter ⚠
- p.Met105Leu Single submitter ⚠
- p.Met282Ile Single submitter ⚠
- p.Phe47Leu Single submitter ⚠
- p.Pro16Ala Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Pro270Leu Single submitter ⚠
- p.Ser163Trp Single submitter ⚠
- p.Ser58Asn Single submitter ⚠
- p.Thr232Ser Single submitter ⚠
- p.Thr313Ala Single submitter ⚠
- p.Thr8Asn Single submitter ⚠
- p.Thr96Met Single submitter ⚠
- p.Trp184Arg Single submitter ⚠
- p.Trp216Arg Single submitter ⚠
- p.Val12Leu Single submitter ⚠
- p.Val137Met Single submitter ⚠
- p.Val151Leu Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val241Asp Single submitter ⚠
- p.Val269Leu Single submitter ⚠
- p.Val269Met Single submitter ⚠
- p.Val275Leu Single submitter ⚠
- p.Val28Ile Single submitter ⚠
- p.Val56Met Single submitter ⚠
- p.Val57Ala Single submitter ⚠
- p.Val57Leu Single submitter ⚠
- p.Val59Met Single submitter ⚠