Sugi Variant

Sugi Variant/LPAR6

LPAR6 — 95 ClinVar variants

All ClinVar germline LPAR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →

3 Pathogenic · 2 Pathogenic/Likely pathogenic · 11 Likely pathogenic · 3 Conflicting · 8 Benign · 1 Benign/Likely benign · 21 Likely benign · 46 Uncertain significance

Full LPAR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 47

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 40

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 5

The independent predictors disagree with each other — read with care.

All LPAR6 variants

Pathogenic 3

Pathogenic/Likely pathogenic 2

Likely pathogenic 11

Conflicting classifications of pathogenicity 3

Benign 8

Benign/Likely benign 1

Likely benign 21

Uncertain significance 46