LPCAT1 — 66 ClinVar variants
All ClinVar germline LPCAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Benign · 5 Likely benign · 59 Uncertain significance
Full LPCAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPCAT1 p.Ala319Val Uncertain significance Single submitter
- LPCAT1 p.Ala327Thr Uncertain significance Single submitter
- LPCAT1 p.Ala370Val Uncertain significance Single submitter
- LPCAT1 p.Ala487Thr Uncertain significance Single submitter
- LPCAT1 p.Ala524Thr Uncertain significance Single submitter
- LPCAT1 p.Ala62Thr Uncertain significance Single submitter
- LPCAT1 p.Ala75Thr Uncertain significance Single submitter
- LPCAT1 p.Arg193Gln Uncertain significance Single submitter
- LPCAT1 p.Arg296Gln Uncertain significance Single submitter
- LPCAT1 p.Arg324Cys Uncertain significance Single submitter
- LPCAT1 p.Arg339Gln Uncertain significance Single submitter
- LPCAT1 p.Arg413Gln Uncertain significance Single submitter
- LPCAT1 p.Arg413Trp Uncertain significance Single submitter
- LPCAT1 p.Arg530His Uncertain significance Single submitter
- LPCAT1 p.Asp181Asn Uncertain significance Single submitter
- LPCAT1 p.Asp328His Uncertain significance Single submitter
- LPCAT1 p.Cys501Arg Uncertain significance Single submitter
- LPCAT1 p.Gln168His Uncertain significance Single submitter
- LPCAT1 p.Gln180Arg Uncertain significance Single submitter
- LPCAT1 p.Gln195Leu Uncertain significance Single submitter
- LPCAT1 p.Gln495Lys Uncertain significance Single submitter
- LPCAT1 p.Glu346Gln Uncertain significance Single submitter
- LPCAT1 p.Glu481Asp Uncertain significance Single submitter
- LPCAT1 p.Glu499Lys Uncertain significance Single submitter
- LPCAT1 p.Glu85Lys Uncertain significance Single submitter
- LPCAT1 p.Gly434Asp Uncertain significance Single submitter
- LPCAT1 p.Gly525Arg Uncertain significance Single submitter
- LPCAT1 p.His477Arg Uncertain significance Single submitter
- LPCAT1 p.His497Arg Uncertain significance Single submitter
- LPCAT1 p.Ile367Thr Uncertain significance Single submitter
- LPCAT1 p.Leu337Val Uncertain significance Single submitter
- LPCAT1 p.Lys347Glu Uncertain significance Single submitter
- LPCAT1 p.Lys426Arg Uncertain significance Single submitter
- LPCAT1 p.Lys470Gln Uncertain significance Single submitter
- LPCAT1 p.Met298Leu Uncertain significance Single submitter
- LPCAT1 p.Met482Val Uncertain significance Single submitter
- LPCAT1 p.Pro287His Uncertain significance Single submitter
- LPCAT1 p.Pro493Leu Uncertain significance Single submitter
- LPCAT1 p.Pro510Arg Uncertain significance Single submitter
- LPCAT1 p.Ser394Gly Uncertain significance Single submitter
- LPCAT1 p.Ser505Leu Uncertain significance Single submitter
- LPCAT1 p.Ser518Ile Uncertain significance Single submitter
- LPCAT1 p.Ser79Phe Uncertain significance Single submitter
- LPCAT1 p.Thr244Ile Uncertain significance Single submitter
- LPCAT1 p.Val231Ile Uncertain significance Single submitter
- LPCAT1 p.Val410Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- LPCAT1 p.Ala480Gly Likely benign Single submitter
- LPCAT1 p.Arg295Gln Uncertain significance Single submitter
- LPCAT1 p.Asp392Asn Uncertain significance Single submitter
- LPCAT1 p.Asp440Val Uncertain significance Single submitter
- LPCAT1 p.Gly198Arg Uncertain significance Single submitter
- LPCAT1 p.Gly303Arg Uncertain significance Single submitter
- LPCAT1 p.Ile471Met Uncertain significance Single submitter
- LPCAT1 p.Met204Thr Uncertain significance Single submitter
- LPCAT1 p.Met64Ile Uncertain significance Single submitter
- LPCAT1 p.Thr52Met Uncertain significance Single submitter
- LPCAT1 p.Tyr309Cys Uncertain significance Single submitter
All LPCAT1 variants
Likely benign 5
- p.Ala229Val Single submitter
- p.Ala480Gly Single submitter ⚠
- p.Pro508Leu Single submitter
- p.Pro88Leu Single submitter
- p.Ser356Ala Single submitter
Uncertain significance 59
- p.Ala319Val Single submitter ⚠
- p.Ala327Thr Single submitter ⚠
- p.Ala370Val Single submitter ⚠
- p.Ala487Thr Single submitter ⚠
- p.Ala524Thr Single submitter ⚠
- p.Ala62Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg193Gln Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg296Gln Single submitter ⚠
- p.Arg324Cys Single submitter ⚠
- p.Arg339Gln Single submitter ⚠
- p.Arg413Gln Single submitter ⚠
- p.Arg413Trp Single submitter ⚠
- p.Arg530His Single submitter ⚠
- p.Asp181Asn Single submitter ⚠
- p.Asp328His Single submitter ⚠
- p.Asp392Asn Single submitter ⚠
- p.Asp440Val Single submitter ⚠
- p.Cys412Phe Single submitter
- p.Cys501Arg Single submitter ⚠
- p.Gln168His Single submitter ⚠
- p.Gln180Arg Single submitter ⚠
- p.Gln195Leu Single submitter ⚠
- p.Gln495Lys Single submitter ⚠
- p.Glu346Gln Single submitter ⚠
- p.Glu481Asp Single submitter ⚠
- p.Glu499Lys Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly198Arg Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly342Arg Single submitter
- p.Gly434Asp Single submitter ⚠
- p.Gly525Arg Single submitter ⚠
- p.His477Arg Single submitter ⚠
- p.His497Arg Single submitter ⚠
- p.Ile367Thr Single submitter ⚠
- p.Ile471Met Single submitter ⚠
- p.Leu337Phe Single submitter
- p.Leu337Val Single submitter ⚠
- p.Lys347Glu Single submitter ⚠
- p.Lys426Arg Single submitter ⚠
- p.Lys470Gln Single submitter ⚠
- p.Met204Thr Single submitter ⚠
- p.Met298Leu Single submitter ⚠
- p.Met482Val Single submitter ⚠
- p.Met64Ile Single submitter ⚠
- p.Pro287His Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Pro510Arg Single submitter ⚠
- p.Ser394Gly Single submitter ⚠
- p.Ser505Leu Single submitter ⚠
- p.Ser518Ile Single submitter ⚠
- p.Ser79Phe Single submitter ⚠
- p.Thr244Ile Single submitter ⚠
- p.Thr52Met Single submitter ⚠
- p.Tyr309Cys Single submitter ⚠
- p.Val231Ile Single submitter ⚠
- p.Val410Ala Single submitter ⚠