LPCAT3 — 50 ClinVar variants
All ClinVar germline LPCAT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 4 Likely benign · 44 Uncertain significance
Full LPCAT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPCAT3 p.Ala123Val Uncertain significance Single submitter
- LPCAT3 p.Ala475Thr Uncertain significance Single submitter
- LPCAT3 p.Ala5Thr Uncertain significance Single submitter
- LPCAT3 p.Arg105Gln Uncertain significance Single submitter
- LPCAT3 p.Arg109His Uncertain significance Single submitter
- LPCAT3 p.Arg179Pro Uncertain significance Single submitter
- LPCAT3 p.Asp314Asn Uncertain significance Single submitter
- LPCAT3 p.Gln24Pro Uncertain significance Single submitter
- LPCAT3 p.Glu25Gly Uncertain significance Single submitter
- LPCAT3 p.Gly135Ser Uncertain significance Single submitter
- LPCAT3 p.Ile468Val Uncertain significance Single submitter
- LPCAT3 p.Leu104Val Uncertain significance Single submitter
- LPCAT3 p.Leu15Pro Uncertain significance Single submitter
- LPCAT3 p.Leu361Ile Uncertain significance Single submitter
- LPCAT3 p.Leu400Pro Uncertain significance Single submitter
- LPCAT3 p.Leu72Phe Uncertain significance Single submitter
- LPCAT3 p.Lys232Thr Uncertain significance Single submitter
- LPCAT3 p.Lys354Arg Uncertain significance Single submitter
- LPCAT3 p.Lys359Gln Uncertain significance Single submitter
- LPCAT3 p.Met143Val Uncertain significance Single submitter
- LPCAT3 p.Met273Val Uncertain significance Single submitter
- LPCAT3 p.Met476Ile Uncertain significance Single submitter
- LPCAT3 p.Phe461Ile Uncertain significance Single submitter
- LPCAT3 p.Ser4Leu Uncertain significance Single submitter
- LPCAT3 p.Ser93Phe Uncertain significance Single submitter
- LPCAT3 p.Thr116Ala Uncertain significance Single submitter
- LPCAT3 p.Thr406Ile Uncertain significance Single submitter
- LPCAT3 p.Tyr272His Uncertain significance Single submitter
- LPCAT3 p.Val114Ile Uncertain significance Single submitter
- LPCAT3 p.Val18Leu Uncertain significance Single submitter
- LPCAT3 p.Val18Phe Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- LPCAT3 p.Asn342His Uncertain significance Single submitter
- LPCAT3 p.Gly163Arg Uncertain significance Single submitter
- LPCAT3 p.Ile334Thr Uncertain significance Single submitter
- LPCAT3 p.Ile460Thr Uncertain significance Single submitter
- LPCAT3 p.Leu465Ile Uncertain significance Single submitter
- LPCAT3 p.Lys485Asn Uncertain significance Single submitter
- LPCAT3 p.Met107Thr Uncertain significance Single submitter
- LPCAT3 p.Tyr255His Uncertain significance Single submitter
- LPCAT3 p.Val345Leu Uncertain significance Single submitter
All LPCAT3 variants
Benign 2
- p.Tyr137= Multiple submitters
- c.367-6T>C Single submitter
Likely benign 4
- p.Ala113= Single submitter
- p.Ile349Thr Single submitter
- p.Leu430= Single submitter
- p.Thr443= Single submitter
Uncertain significance 44
- p.Ala123Val Single submitter ⚠
- p.Ala475Thr Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg179Pro Single submitter ⚠
- p.Asn342His Single submitter ⚠
- p.Asp314Asn Single submitter ⚠
- p.Cys270fs Single submitter
- p.Gln24Pro Single submitter ⚠
- p.Glu25Gly Single submitter ⚠
- p.Gly135Ser Single submitter ⚠
- p.Gly163Arg Single submitter ⚠
- p.His74fs Single submitter
- p.Ile334Thr Single submitter ⚠
- p.Ile460Thr Single submitter ⚠
- p.Ile468Val Single submitter ⚠
- p.Leu104Val Single submitter ⚠
- p.Leu15Pro Single submitter ⚠
- p.Leu361Ile Single submitter ⚠
- p.Leu400Pro Single submitter ⚠
- p.Leu465Ile Single submitter ⚠
- p.Leu72Phe Single submitter ⚠
- p.Lys232Thr Single submitter ⚠
- p.Lys354Arg Single submitter ⚠
- p.Lys359Gln Single submitter ⚠
- p.Lys485Asn Single submitter ⚠
- p.Met107Thr Single submitter ⚠
- p.Met143Val Single submitter ⚠
- p.Met273Val Single submitter ⚠
- p.Met476Ile Single submitter ⚠
- p.Phe279Ser Single submitter
- p.Phe461Ile Single submitter ⚠
- p.Ser4Leu Single submitter ⚠
- p.Ser93Phe Single submitter ⚠
- p.Thr116Ala Single submitter ⚠
- p.Thr331Ile Single submitter
- p.Thr406Ile Single submitter ⚠
- p.Tyr255His Single submitter ⚠
- p.Tyr272His Single submitter ⚠
- p.Val114Ile Single submitter ⚠
- p.Val18Leu Single submitter ⚠
- p.Val18Phe Single submitter ⚠
- p.Val345Leu Single submitter ⚠