Sugi Variant

Sugi Variant/LPIN2

LPIN2 — 1015 ClinVar variants

All ClinVar germline LPIN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 332 flagged for review →

22 Pathogenic · 6 Pathogenic/Likely pathogenic · 20 Likely pathogenic · 57 Conflicting · 68 Benign · 31 Benign/Likely benign · 360 Likely benign · 451 Uncertain significance

Full LPIN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 332

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 14

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 289

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 289

Predictors split 28

The independent predictors disagree with each other — read with care.

All LPIN2 variants

Pathogenic 22

Pathogenic/Likely pathogenic 6

Likely pathogenic 20

Conflicting classifications of pathogenicity 57

Benign 68

Benign/Likely benign 31

Likely benign 360

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 451

Showing the top 300 by review status; the full set is in the sitemap.