LPO — 118 ClinVar variants
All ClinVar germline LPO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 105 flagged for review →
8 Benign · 4 Likely benign · 106 Uncertain significance
Full LPO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 105
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 83
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPO p.Ala152Glu Uncertain significance Single submitter
- LPO p.Ala161Glu Uncertain significance Single submitter
- LPO p.Ala192Thr Uncertain significance Single submitter
- LPO p.Ala231Thr Uncertain significance Single submitter
- LPO p.Ala231Val Uncertain significance Single submitter
- LPO p.Ala26Val Uncertain significance Single submitter
- LPO p.Ala317Thr Uncertain significance Single submitter
- LPO p.Ala708Gly Uncertain significance Single submitter
- LPO p.Arg193Gln Uncertain significance Single submitter
- LPO p.Arg319Cys Uncertain significance Single submitter
- LPO p.Arg362His Uncertain significance Single submitter
- LPO p.Arg414Trp Uncertain significance Single submitter
- LPO p.Arg427Lys Uncertain significance Single submitter
- LPO p.Arg535His Uncertain significance Single submitter
- LPO p.Arg53Gln Uncertain significance Single submitter
- LPO p.Arg544Gly Uncertain significance Single submitter
- LPO p.Arg557Pro Uncertain significance Single submitter
- LPO p.Arg559Gln Uncertain significance Single submitter
- LPO p.Arg621Ser Uncertain significance Single submitter
- LPO p.Arg623Gln Uncertain significance Single submitter
- LPO p.Arg640His Uncertain significance Single submitter
- LPO p.Arg68Gln Uncertain significance Single submitter
- LPO p.Arg80Gln Uncertain significance Single submitter
- LPO p.Arg80Trp Uncertain significance Single submitter
- LPO p.Asn146His Uncertain significance Single submitter
- LPO p.Asn391Lys Uncertain significance Single submitter
- LPO p.Asn401Lys Uncertain significance Single submitter
- LPO p.Asn649Lys Uncertain significance Single submitter
- LPO p.Asp453Tyr Uncertain significance Single submitter
- LPO p.Asp51Asn Uncertain significance Single submitter
- LPO p.Asp560His Uncertain significance Single submitter
- LPO p.Asp605His Uncertain significance Single submitter
- LPO p.Asp659Gly Uncertain significance Single submitter
- LPO p.Asp659Tyr Uncertain significance Single submitter
- LPO p.Asp672Val Uncertain significance Single submitter
- LPO p.Cys123Tyr Uncertain significance Single submitter
- LPO p.Cys274Tyr Uncertain significance Single submitter
- LPO p.Cys354Tyr Uncertain significance Single submitter
- LPO p.Gln271His Uncertain significance Single submitter
- LPO p.Gln662Leu Uncertain significance Single submitter
- LPO p.Glu313Lys Uncertain significance Single submitter
- LPO p.Glu583Asp Uncertain significance Single submitter
- LPO p.Gly281Trp Uncertain significance Single submitter
- LPO p.Gly532Arg Uncertain significance Single submitter
- LPO p.Gly602Arg Uncertain significance Single submitter
- LPO p.Gly612Glu Uncertain significance Single submitter
- LPO p.His546Arg Uncertain significance Single submitter
- LPO p.Ile377Thr Uncertain significance Single submitter
- LPO p.Leu430Val Uncertain significance Single submitter
- LPO p.Leu534Val Uncertain significance Single submitter
- LPO p.Lys273Thr Uncertain significance Single submitter
- LPO p.Lys440Arg Uncertain significance Single submitter
- LPO p.Lys440Gln Uncertain significance Single submitter
- LPO p.Lys591Glu Uncertain significance Single submitter
- LPO p.Met275Leu Uncertain significance Single submitter
- LPO p.Met330Leu Uncertain significance Single submitter
- LPO p.Met524Thr Uncertain significance Single submitter
- LPO p.Phe497Ser Uncertain significance Single submitter
- LPO p.Phe636Leu Uncertain significance Single submitter
- LPO p.Pro128Ala Uncertain significance Single submitter
- LPO p.Pro134Arg Uncertain significance Single submitter
- LPO p.Pro134Leu Uncertain significance Single submitter
- LPO p.Pro188Ser Uncertain significance Single submitter
- LPO p.Pro258Leu Uncertain significance Single submitter
- LPO p.Pro345His Uncertain significance Single submitter
- LPO p.Pro351Ser Uncertain significance Single submitter
- LPO p.Pro444Leu Uncertain significance Single submitter
- LPO p.Pro489Ser Uncertain significance Single submitter
- LPO p.Pro706Leu Uncertain significance Single submitter
- LPO p.Ser238Gly Uncertain significance Single submitter
- LPO p.Ser291Tyr Uncertain significance Single submitter
- LPO p.Thr179Met Uncertain significance Single submitter
- LPO p.Thr183Lys Uncertain significance Single submitter
- LPO p.Thr360Ile Uncertain significance Single submitter
- LPO p.Thr500Ser Uncertain significance Single submitter
- LPO p.Thr542Ala Uncertain significance Single submitter
- LPO p.Thr81Met Uncertain significance Single submitter
- LPO p.Tyr566Cys Uncertain significance Single submitter
- LPO p.Tyr691Cys Uncertain significance Single submitter
- LPO p.Val283Ile Uncertain significance Single submitter
- LPO p.Val471Ile Uncertain significance Single submitter
- LPO p.Val694Leu Uncertain significance Single submitter
- LPO p.Val694Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- LPO p.Ala166Val Uncertain significance Single submitter
- LPO p.Arg388His Uncertain significance Single submitter
- LPO p.Arg392Gln Uncertain significance Single submitter
- LPO p.Arg668His Uncertain significance Single submitter
- LPO p.Arg82Cys Uncertain significance Single submitter
- LPO p.Arg86Cys Uncertain significance Single submitter
- LPO p.Asn401His Uncertain significance Single submitter
- LPO p.Asp608Glu Uncertain significance Single submitter
- LPO p.Gly122Val Uncertain significance Single submitter
- LPO p.Gly186Asp Uncertain significance Single submitter
- LPO p.Ile199Thr Uncertain significance Single submitter
- LPO p.Ile297Asn Uncertain significance Single submitter
- LPO p.Leu661Val Uncertain significance Single submitter
- LPO p.Phe230Leu Uncertain significance Single submitter
- LPO p.Phe693Leu Uncertain significance Single submitter
- LPO p.Pro266Leu Uncertain significance Single submitter
- LPO p.Pro431Leu Uncertain significance Single submitter
- LPO p.Pro564Leu Uncertain significance Single submitter
- LPO p.Pro578Leu Uncertain significance Single submitter
- LPO p.Ser473Tyr Uncertain significance Single submitter
- LPO p.Tyr346Cys Uncertain significance Single submitter
- LPO p.Val45Ala Uncertain significance Single submitter
All LPO variants
Benign 8
- c.164+9G>C Multiple submitters
- c.1931+10T>C Multiple submitters
- p.Leu10= Multiple submitters
- p.Leu344= Multiple submitters
- p.Ser374= Multiple submitters
- p.Thr105Ile Multiple submitters
- c.164+10AC[22] Single submitter
- c.164+9_164+12del Single submitter
Likely benign 4
- p.Ala268Val Single submitter
- p.Asn673= Single submitter
- p.Asp109Gly Single submitter
- p.Ser312= Single submitter
Uncertain significance 106
- p.Ala152Glu Single submitter ⚠
- p.Ala161Glu Single submitter ⚠
- p.Ala166Val Single submitter ⚠
- p.Ala192Thr Single submitter ⚠
- p.Ala231Thr Single submitter ⚠
- p.Ala231Val Single submitter ⚠
- p.Ala26Val Single submitter ⚠
- p.Ala317Thr Single submitter ⚠
- p.Ala708Gly Single submitter ⚠
- p.Arg193Gln Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Arg392Gln Single submitter ⚠
- p.Arg414Trp Single submitter ⚠
- p.Arg427Lys Single submitter ⚠
- p.Arg477Cys Single submitter
- p.Arg535His Single submitter ⚠
- p.Arg53Gln Single submitter ⚠
- p.Arg544Gly Single submitter ⚠
- p.Arg557Pro Single submitter ⚠
- p.Arg559Gln Single submitter ⚠
- p.Arg621Ser Single submitter ⚠
- p.Arg623Gln Single submitter ⚠
- p.Arg640His Single submitter ⚠
- p.Arg668His Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg86Cys Single submitter ⚠
- p.Asn146His Single submitter ⚠
- p.Asn391Lys Single submitter ⚠
- p.Asn401His Single submitter ⚠
- p.Asn401Lys Single submitter ⚠
- p.Asn649Lys Single submitter ⚠
- p.Asp453Tyr Single submitter ⚠
- p.Asp51Asn Single submitter ⚠
- p.Asp560His Single submitter ⚠
- p.Asp605His Single submitter ⚠
- p.Asp608Glu Single submitter ⚠
- p.Asp659Gly Single submitter ⚠
- p.Asp659Tyr Single submitter ⚠
- p.Asp672Val Single submitter ⚠
- p.Cys123Tyr Single submitter ⚠
- p.Cys274Tyr Single submitter ⚠
- p.Cys354Tyr Single submitter ⚠
- p.Gln271His Single submitter ⚠
- p.Gln662Leu Single submitter ⚠
- p.Glu313Lys Single submitter ⚠
- p.Glu583Asp Single submitter ⚠
- p.Gly122Val Single submitter ⚠
- p.Gly186Asp Single submitter ⚠
- p.Gly281Trp Single submitter ⚠
- p.Gly532Arg Single submitter ⚠
- p.Gly602Arg Single submitter ⚠
- p.Gly612Glu Single submitter ⚠
- p.His546Arg Single submitter ⚠
- p.Ile199Thr Single submitter ⚠
- p.Ile297Asn Single submitter ⚠
- p.Ile377Thr Single submitter ⚠
- p.Leu430Val Single submitter ⚠
- p.Leu534Val Single submitter ⚠
- p.Leu661Val Single submitter ⚠
- p.Lys273Thr Single submitter ⚠
- p.Lys440Arg Single submitter ⚠
- p.Lys440Gln Single submitter ⚠
- p.Lys591Glu Single submitter ⚠
- p.Met275Leu Single submitter ⚠
- p.Met330Leu Single submitter ⚠
- p.Met524Thr Single submitter ⚠
- p.Phe230Leu Single submitter ⚠
- p.Phe497Ser Single submitter ⚠
- p.Phe636Leu Single submitter ⚠
- p.Phe693Leu Single submitter ⚠
- p.Pro128Ala Single submitter ⚠
- p.Pro134Arg Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Pro258Leu Single submitter ⚠
- p.Pro266Leu Single submitter ⚠
- p.Pro345His Single submitter ⚠
- p.Pro351Ser Single submitter ⚠
- p.Pro431Leu Single submitter ⚠
- p.Pro444Leu Single submitter ⚠
- p.Pro489Ser Single submitter ⚠
- p.Pro564Leu Single submitter ⚠
- p.Pro578Leu Single submitter ⚠
- p.Pro706Leu Single submitter ⚠
- p.Ser238Gly Single submitter ⚠
- p.Ser291Tyr Single submitter ⚠
- p.Ser473Tyr Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr183Lys Single submitter ⚠
- p.Thr360Ile Single submitter ⚠
- p.Thr500Ser Single submitter ⚠
- p.Thr542Ala Single submitter ⚠
- p.Thr81Met Single submitter ⚠
- p.Tyr346Cys Single submitter ⚠
- p.Tyr566Cys Single submitter ⚠
- p.Tyr691Cys Single submitter ⚠
- p.Val283Ile Single submitter ⚠
- p.Val45Ala Single submitter ⚠
- p.Val471Ile Single submitter ⚠
- p.Val694Leu Single submitter ⚠
- p.Val694Met Single submitter ⚠