LPP — 157 ClinVar variants
All ClinVar germline LPP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
1 Conflicting · 39 Benign · 1 Benign/Likely benign · 13 Likely benign · 103 Uncertain significance
Full LPP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LPP p.Ala185Ser Uncertain significance Single submitter
- LPP p.Ala237Ser Uncertain significance Single submitter
- LPP p.Ala290Val Uncertain significance Single submitter
- LPP p.Ala518Val Uncertain significance Single submitter
- LPP p.Arg140Gln Uncertain significance Single submitter
- LPP p.Arg268Trp Uncertain significance Single submitter
- LPP p.Arg600Gly Uncertain significance Single submitter
- LPP p.Asn31Tyr Uncertain significance Single submitter
- LPP p.Asn448Lys Uncertain significance Single submitter
- LPP p.Asp312Tyr Uncertain significance Single submitter
- LPP p.Asp358Glu Uncertain significance Single submitter
- LPP p.Asp410Asn Uncertain significance Single submitter
- LPP p.Cys262Arg Uncertain significance Single submitter
- LPP p.Cys364Arg Uncertain significance Single submitter
- LPP p.Cys441Ser Uncertain significance Single submitter
- LPP p.Cys468Arg Uncertain significance Single submitter
- LPP p.Gln224Leu Uncertain significance Single submitter
- LPP p.Gln249Lys Uncertain significance Single submitter
- LPP p.Glu284Ala Uncertain significance Single submitter
- LPP p.Glu298Gly Uncertain significance Single submitter
- LPP p.Gly147Arg Uncertain significance Single submitter
- LPP p.Gly241Arg Uncertain significance Single submitter
- LPP p.Gly270Ser Uncertain significance Single submitter
- LPP p.Gly286Glu Uncertain significance Single submitter
- LPP p.Gly308Arg Uncertain significance Single submitter
- LPP p.Gly308Glu Uncertain significance Single submitter
- LPP p.Gly321Asp Uncertain significance Single submitter
- LPP p.Gly372Asp Uncertain significance Single submitter
- LPP p.Gly420Arg Uncertain significance Single submitter
- LPP p.Gly520Arg Uncertain significance Single submitter
- LPP p.Gly63Val Uncertain significance Single submitter
- LPP p.Ile356Leu Uncertain significance Single submitter
- LPP p.Ile356Val Uncertain significance Single submitter
- LPP p.Ile446Met Uncertain significance Single submitter
- LPP p.Ile470Val Uncertain significance Single submitter
- LPP p.Leu117Pro Uncertain significance Single submitter
- LPP p.Leu368Ser Uncertain significance Single submitter
- LPP p.Leu393Pro Uncertain significance Single submitter
- LPP p.Lys100Thr Uncertain significance Single submitter
- LPP p.Lys450Arg Uncertain significance Single submitter
- LPP p.Lys531Thr Uncertain significance Single submitter
- LPP p.Met235Val Uncertain significance Single submitter
- LPP p.Met345Arg Uncertain significance Single submitter
- LPP p.Met345Leu Uncertain significance Single submitter
- LPP p.Met504Ile Uncertain significance Single submitter
- LPP p.Phe532Tyr Uncertain significance Single submitter
- LPP p.Pro142Ser Uncertain significance Single submitter
- LPP p.Pro152Leu Uncertain significance Single submitter
- LPP p.Pro201Ala Uncertain significance Single submitter
- LPP p.Pro20Arg Uncertain significance Single submitter
- LPP p.Pro232Thr Uncertain significance Single submitter
- LPP p.Pro278Thr Uncertain significance Single submitter
- LPP p.Pro283Leu Uncertain significance Single submitter
- LPP p.Pro291Ser Uncertain significance Single submitter
- LPP p.Pro315His Uncertain significance Single submitter
- LPP p.Pro342Ala Uncertain significance Single submitter
- LPP p.Pro370Leu Uncertain significance Single submitter
- LPP p.Pro389Gln Uncertain significance Single submitter
- LPP p.Pro467Leu Uncertain significance Single submitter
- LPP p.Pro74Leu Uncertain significance Single submitter
- LPP p.Ser11Asn Uncertain significance Single submitter
- LPP p.Ser123Tyr Uncertain significance Single submitter
-
LPP p.Ser151Pro
Uncertain significance
Single submitter
acute myeloid leukemia
- LPP p.Ser155Leu Uncertain significance Single submitter
- LPP p.Ser178Cys Uncertain significance Single submitter
- LPP p.Ser227Leu Uncertain significance Single submitter
- LPP p.Ser266Leu Uncertain significance Single submitter
- LPP p.Ser381Leu Uncertain significance Single submitter
- LPP p.Thr156Ile Uncertain significance Single submitter
- LPP p.Thr211Ala Uncertain significance Single submitter
- LPP p.Thr605Asn Uncertain significance Single submitter
- LPP p.Tyr251Cys Uncertain significance Single submitter
- LPP p.Tyr251His Uncertain significance Single submitter
- LPP p.Tyr317Cys Uncertain significance Single submitter
- LPP p.Val193Leu Uncertain significance Single submitter
- LPP p.Val348Asp Uncertain significance Single submitter
- LPP p.Val360Ala Uncertain significance Single submitter
- LPP p.Val436Ile Uncertain significance Single submitter
- LPP p.Val439Met Uncertain significance Single submitter
- LPP p.Val603Met Uncertain significance Single submitter
- LPP p.Pro153Thr Uncertain significance No assertion criteria
Predictors split 23
The independent predictors disagree with each other — read with care.
-
LPP p.Arg140Trp
Uncertain significance
Multiple submitters
acute myeloid leukemia
- LPP p.Gly573Ser Likely benign Multiple submitters
- LPP p.Pro167Leu Benign/Likely benign Multiple submitters
- LPP p.Ala50Thr Uncertain significance Single submitter
- LPP p.Arg114Cys Uncertain significance Single submitter
- LPP p.Arg114His Uncertain significance Single submitter
- LPP p.Arg218Trp Uncertain significance Single submitter
- LPP p.Arg388Cys Likely benign Single submitter
- LPP p.Arg388Leu Uncertain significance Single submitter
- LPP p.Arg418His Uncertain significance Single submitter
- LPP p.Arg507His Uncertain significance Single submitter
- LPP p.Asn168Lys Uncertain significance Single submitter
- LPP p.Gln549Arg Uncertain significance Single submitter
- LPP p.Ile356Thr Uncertain significance Single submitter
- LPP p.Ile601Val Uncertain significance Single submitter
- LPP p.Lys461Asn Uncertain significance Single submitter
- LPP p.Pro170Ser Uncertain significance Single submitter
- LPP p.Pro219Leu Uncertain significance Single submitter
- LPP p.Pro277Leu Uncertain significance Single submitter
- LPP p.Pro57Ala Uncertain significance Single submitter
- LPP p.Val503Met Uncertain significance Single submitter
-
LPP p.Arg22Trp
Likely benign
No assertion criteria
LPP-related disorder
-
LPP p.Thr212Met
Likely benign
No assertion criteria
LPP-related disorder
All LPP variants
Conflicting classifications of pathogenicity 1
- p.Arg452Ter Single submitter acute myeloid leukemia
Benign 39
- c.1113+51T>C Multiple submitters
- c.1240+249G>A Multiple submitters
- c.1240+75A>G Multiple submitters
- c.1410+155C>T Multiple submitters
- c.1410+157T>C Multiple submitters
- c.1410+162G>A Multiple submitters
- c.1410+165T>C Multiple submitters
- c.1589+20G>A Multiple submitters
- c.1590-73C>T Multiple submitters
- c.1710+99G>T Multiple submitters
- c.1711-143G>A Multiple submitters
- c.306+58A>T Multiple submitters
- c.306+90G>T Multiple submitters
- c.429+106G>T Multiple submitters
- c.429+118T>G Multiple submitters
- c.429+122T>G Multiple submitters
- c.429+126T>G Multiple submitters
- c.429+130T>G Multiple submitters
- c.-9-81T>G Multiple submitters
- p.Arg535= Multiple submitters
- p.Asp314= Multiple submitters
- p.Cys465= Multiple submitters
- p.Gly453= Multiple submitters
- p.Ile196= Multiple submitters
- p.Ser259Pro Multiple submitters
- p.Ser381= Multiple submitters
- p.Thr146Ala Multiple submitters
- p.Tyr346His Multiple submitters
- c.1241-311A>G Single submitter
- c.1710+112G>A Single submitter
- c.1710+310del Single submitter
- c.193+253C>A Single submitter
- c.429+106_429+117del Single submitter
- c.429+106_429+121del Single submitter
- c.429+199dup Single submitter
- c.-9-202C>T Single submitter
- c.-9-216_-9-214del Single submitter
- p.Gly309Asp Single submitter
- p.Pro363Ser No assertion criteria LPP-related disorder
Benign/Likely benign 1
- p.Pro167Leu Multiple submitters ⚠
Likely benign 13
- p.Gly573Ser Multiple submitters ⚠
- p.Ala290Thr Single submitter
- p.Ala365= Single submitter
- p.Arg388Cys Single submitter ⚠
- p.Pro545= Single submitter
- p.Ser155= Single submitter
- p.Ser246Leu Single submitter
- c.1589+8A>G No assertion criteria LPP-related disorder
- p.Ala302= No assertion criteria LPP-related disorder
- p.Arg22Trp No assertion criteria LPP-related disorder ⚠
- p.Gly245= No assertion criteria LPP-related disorder
- p.Ser145= No assertion criteria LPP-related disorder
- p.Thr212Met No assertion criteria LPP-related disorder ⚠
Uncertain significance 103
- p.Arg140Trp Multiple submitters acute myeloid leukemia ⚠
- p.Ala185Ser Single submitter ⚠
- p.Ala237Ser Single submitter ⚠
- p.Ala290Val Single submitter ⚠
- p.Ala50Thr Single submitter ⚠
- p.Ala518Val Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg218Trp Single submitter ⚠
- p.Arg268Trp Single submitter ⚠
- p.Arg388Leu Single submitter ⚠
- p.Arg418Gly Single submitter
- p.Arg418His Single submitter ⚠
- p.Arg507His Single submitter ⚠
- p.Arg600Gly Single submitter ⚠
- p.Asn168Lys Single submitter ⚠
- p.Asn31Tyr Single submitter ⚠
- p.Asn448Lys Single submitter ⚠
- p.Asp312Tyr Single submitter ⚠
- p.Asp358Glu Single submitter ⚠
- p.Asp410Asn Single submitter ⚠
- p.Cys262Arg Single submitter ⚠
- p.Cys364Arg Single submitter ⚠
- p.Cys441Ser Single submitter ⚠
- p.Cys468Arg Single submitter ⚠
- p.Gln224Leu Single submitter ⚠
- p.Gln249Lys Single submitter ⚠
- p.Gln435Arg Single submitter
- p.Gln549Arg Single submitter ⚠
- p.Glu284Ala Single submitter ⚠
- p.Glu298Gly Single submitter ⚠
- p.Gly147Arg Single submitter ⚠
- p.Gly241Arg Single submitter ⚠
- p.Gly270Ser Single submitter ⚠
- p.Gly286Glu Single submitter ⚠
- p.Gly308Arg Single submitter ⚠
- p.Gly308Glu Single submitter ⚠
- p.Gly321Asp Single submitter ⚠
- p.Gly372Asp Single submitter ⚠
- p.Gly420Arg Single submitter ⚠
- p.Gly520Arg Single submitter ⚠
- p.Gly63Val Single submitter ⚠
- p.Ile356Leu Single submitter ⚠
- p.Ile356Thr Single submitter ⚠
- p.Ile356Val Single submitter ⚠
- p.Ile446Met Single submitter ⚠
- p.Ile470Val Single submitter ⚠
- p.Ile601Val Single submitter ⚠
- p.Leu117Pro Single submitter ⚠
- p.Leu368Ser Single submitter ⚠
- p.Leu393Pro Single submitter ⚠
- p.Lys100Thr Single submitter ⚠
- p.Lys450Arg Single submitter ⚠
- p.Lys461Asn Single submitter ⚠
- p.Lys531Thr Single submitter ⚠
- p.Met235Val Single submitter ⚠
- p.Met345Arg Single submitter ⚠
- p.Met345Leu Single submitter ⚠
- p.Met504Ile Single submitter ⚠
- p.Phe532Tyr Single submitter ⚠
- p.Pro142Ser Single submitter ⚠
- p.Pro152Leu Single submitter ⚠
- p.Pro170Ser Single submitter ⚠
- p.Pro201Ala Single submitter ⚠
- p.Pro20Arg Single submitter ⚠
- p.Pro219Leu Single submitter ⚠
- p.Pro232Thr Single submitter ⚠
- p.Pro277Leu Single submitter ⚠
- p.Pro278Thr Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro291Ser Single submitter ⚠
- p.Pro315His Single submitter ⚠
- p.Pro342Ala Single submitter ⚠
- p.Pro370Leu Single submitter ⚠
- p.Pro389Gln Single submitter ⚠
- p.Pro467Arg Single submitter
- p.Pro467Leu Single submitter ⚠
- p.Pro57Ala Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Ser11Asn Single submitter ⚠
- p.Ser123Tyr Single submitter ⚠
- p.Ser151Pro Single submitter acute myeloid leukemia ⚠
- p.Ser155Leu Single submitter ⚠
- p.Ser178Cys Single submitter ⚠
- p.Ser227Leu Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser381Leu Single submitter ⚠
- p.Thr156Ile Single submitter ⚠
- p.Thr211Ala Single submitter ⚠
- p.Thr605Asn Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Tyr251His Single submitter ⚠
- p.Tyr317Cys Single submitter ⚠
- p.Val193Leu Single submitter ⚠
- p.Val348Asp Single submitter ⚠
- p.Val360Ala Single submitter ⚠
- p.Val423Ile Single submitter
- p.Val436Ile Single submitter ⚠
- p.Val439Met Single submitter ⚠
- p.Val503Met Single submitter ⚠
- p.Val603Met Single submitter ⚠
- p.Pro153Thr No assertion criteria ⚠