LRFN5 — 80 ClinVar variants
All ClinVar germline LRFN5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
6 Benign · 7 Likely benign · 67 Uncertain significance
Full LRFN5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LRFN5 p.Ala148Thr Uncertain significance Single submitter
- LRFN5 p.Ala17Ser Uncertain significance Single submitter
- LRFN5 p.Ala424Thr Uncertain significance Single submitter
- LRFN5 p.Ala701Ser Uncertain significance Single submitter
- LRFN5 p.Arg252Gly Uncertain significance Single submitter
- LRFN5 p.Arg272His Uncertain significance Single submitter
- LRFN5 p.Arg462Gly Uncertain significance Single submitter
- LRFN5 p.Arg715Ser Uncertain significance Single submitter
- LRFN5 p.Asn32Thr Uncertain significance Single submitter
- LRFN5 p.Asn440His Uncertain significance Single submitter
- LRFN5 p.Asn662Asp Uncertain significance Single submitter
- LRFN5 p.Asn671Ser Uncertain significance Single submitter
- LRFN5 p.Asp419His Uncertain significance Single submitter
- LRFN5 p.Cys263Tyr Uncertain significance Single submitter
- LRFN5 p.Cys602Ser Uncertain significance Single submitter
- LRFN5 p.Gln18His Uncertain significance Single submitter
- LRFN5 p.Gln368Glu Uncertain significance Single submitter
- LRFN5 p.Gln601Glu Uncertain significance Single submitter
- LRFN5 p.Gln612Leu Uncertain significance Single submitter
- LRFN5 p.Gln612Lys Uncertain significance Single submitter
- LRFN5 p.Gln643Arg Uncertain significance Single submitter
- LRFN5 p.Gly535Arg Uncertain significance Single submitter
- LRFN5 p.His294Gln Uncertain significance Single submitter
- LRFN5 p.His386Gln Uncertain significance Single submitter
- LRFN5 p.His596Arg Uncertain significance Single submitter
- LRFN5 p.His696Gln Uncertain significance Single submitter
- LRFN5 p.Ile277Thr Uncertain significance Single submitter
- LRFN5 p.Lys469Arg Uncertain significance Single submitter
- LRFN5 p.Lys646Arg Uncertain significance Single submitter
- LRFN5 p.Lys67Arg Uncertain significance Single submitter
- LRFN5 p.Met118Val Uncertain significance Single submitter
- LRFN5 p.Met520Leu Uncertain significance Single submitter
- LRFN5 p.Phe6Leu Uncertain significance Single submitter
- LRFN5 p.Pro586Ser Uncertain significance Single submitter
- LRFN5 p.Pro631Ala Uncertain significance Single submitter
- LRFN5 p.Pro631Ser Uncertain significance Single submitter
- LRFN5 p.Ser172Asn Uncertain significance Single submitter
- LRFN5 p.Ser567Asn Uncertain significance Single submitter
- LRFN5 p.Ser618Leu Uncertain significance Single submitter
- LRFN5 p.Ser692Tyr Uncertain significance Single submitter
- LRFN5 p.Thr332Ser Uncertain significance Single submitter
- LRFN5 p.Thr564Ile Uncertain significance Single submitter
- LRFN5 p.Thr606Pro Uncertain significance Single submitter
- LRFN5 p.Thr624Ser Uncertain significance Single submitter
- LRFN5 p.Thr649Pro Uncertain significance Single submitter
- LRFN5 p.Thr691Lys Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- LRFN5 p.Asn48Lys Uncertain significance Single submitter
- LRFN5 p.Asp259His Uncertain significance Single submitter
- LRFN5 p.Asp492Gly Uncertain significance Single submitter
- LRFN5 p.Cys555Phe Uncertain significance Single submitter
- LRFN5 p.Gln450His Uncertain significance Single submitter
- LRFN5 p.Gly189Glu Uncertain significance Single submitter
- LRFN5 p.Gly41Glu Uncertain significance Single submitter
- LRFN5 p.Gly443Arg Uncertain significance Single submitter
- LRFN5 p.His180Arg Uncertain significance Single submitter
- LRFN5 p.Lys376Asn Uncertain significance Single submitter
- LRFN5 p.Lys553Thr Uncertain significance Single submitter
- LRFN5 p.Phe274Tyr Uncertain significance Single submitter
- LRFN5 p.Ser139Cys Uncertain significance Single submitter
-
LRFN5 p.Ser192Phe
Uncertain significance
Single submitter
Inborn genetic diseases
- LRFN5 p.Thr190Ile Uncertain significance Single submitter
-
LRFN5 p.Thr290Ile
Uncertain significance
Single submitter
Inborn genetic diseases
- LRFN5 p.Thr356Ala Uncertain significance Single submitter
- LRFN5 p.Thr430Met Uncertain significance Single submitter
- LRFN5 p.Tyr156Cys Uncertain significance Single submitter
-
LRFN5 p.Phe544Val
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All LRFN5 variants
Benign 6
- p.Ala59= No assertion criteria LRFN5-related disorder
- p.Glu717= No assertion criteria LRFN5-related disorder
- p.Phe147= No assertion criteria LRFN5-related disorder
- p.Ser522= No assertion criteria LRFN5-related disorder
- p.Ser622Phe No assertion criteria LRFN5-related disorder
- p.Ser685= No assertion criteria LRFN5-related disorder
Likely benign 7
- p.Thr198= Single submitter
- p.Thr86= Single submitter
- c.2143-24CTTTTT[3] No assertion criteria LRFN5-related disorder
- p.Arg681= No assertion criteria LRFN5-related disorder
- p.Glu315= No assertion criteria LRFN5-related disorder
- p.Phe544Val No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
- p.Thr407= No assertion criteria LRFN5-related disorder
Uncertain significance 67
- p.Ala148Thr Single submitter ⚠
- p.Ala17Ser Single submitter ⚠
- p.Ala424Thr Single submitter ⚠
- p.Ala701Ser Single submitter ⚠
- p.Arg252Gly Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg462Gly Single submitter ⚠
- p.Arg715Ser Single submitter ⚠
- p.Asn32Thr Single submitter ⚠
- p.Asn440His Single submitter ⚠
- p.Asn48Lys Single submitter ⚠
- p.Asn662Asp Single submitter ⚠
- p.Asn671Ser Single submitter ⚠
- p.Asp259His Single submitter ⚠
- p.Asp419His Single submitter ⚠
- p.Asp492Gly Single submitter ⚠
- p.Cys263Tyr Single submitter ⚠
- p.Cys555Phe Single submitter ⚠
- p.Cys602Ser Single submitter ⚠
- p.Gln18His Single submitter ⚠
- p.Gln368Glu Single submitter ⚠
- p.Gln450His Single submitter ⚠
- p.Gln601Glu Single submitter ⚠
- p.Gln612Leu Single submitter ⚠
- p.Gln612Lys Single submitter ⚠
- p.Gln643Arg Single submitter ⚠
- p.Gly189Glu Single submitter ⚠
- p.Gly325Glu Single submitter
- p.Gly41Glu Single submitter ⚠
- p.Gly443Arg Single submitter ⚠
- p.Gly535Arg Single submitter ⚠
- p.His180Arg Single submitter ⚠
- p.His294Gln Single submitter ⚠
- p.His386Gln Single submitter ⚠
- p.His596Arg Single submitter ⚠
- p.His696Gln Single submitter ⚠
- p.Ile186Val Single submitter
- p.Ile277Thr Single submitter ⚠
- p.Lys376Asn Single submitter ⚠
- p.Lys469Arg Single submitter ⚠
- p.Lys553Thr Single submitter ⚠
- p.Lys646Arg Single submitter ⚠
- p.Lys67Arg Single submitter ⚠
- p.Met118Val Single submitter ⚠
- p.Met520Leu Single submitter ⚠
- p.Phe274Tyr Single submitter ⚠
- p.Phe6Leu Single submitter ⚠
- p.Pro586Ser Single submitter ⚠
- p.Pro631Ala Single submitter ⚠
- p.Pro631Ser Single submitter ⚠
- p.Ser139Cys Single submitter ⚠
- p.Ser172Asn Single submitter ⚠
- p.Ser192Phe Single submitter Inborn genetic diseases ⚠
- p.Ser567Asn Single submitter ⚠
- p.Ser618Leu Single submitter ⚠
- p.Ser692Tyr Single submitter ⚠
- p.Thr190Ile Single submitter ⚠
- p.Thr290Ile Single submitter Inborn genetic diseases ⚠
- p.Thr332Ser Single submitter ⚠
- p.Thr356Ala Single submitter ⚠
- p.Thr430Met Single submitter ⚠
- p.Thr564Ile Single submitter ⚠
- p.Thr606Pro Single submitter ⚠
- p.Thr624Ser Single submitter ⚠
- p.Thr649Pro Single submitter ⚠
- p.Thr691Lys Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠