Sugi Variant

Sugi Variant/LRP12

LRP12 — 125 ClinVar variants

All ClinVar germline LRP12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →

1 Pathogenic · 1 Conflicting · 2 Benign · 14 Likely benign · 107 Uncertain significance

Full LRP12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 103

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 83

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All LRP12 variants

Pathogenic 1

Conflicting classifications of pathogenicity 1

Benign 2

Likely benign 14

Uncertain significance 107