LRRC19 — 59 ClinVar variants
All ClinVar germline LRRC19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Benign · 9 Likely benign · 49 Uncertain significance
Full LRRC19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LRRC19 p.Ala116Thr Uncertain significance Single submitter
- LRRC19 p.Ala224Val Uncertain significance Single submitter
- LRRC19 p.Arg106Thr Uncertain significance Single submitter
- LRRC19 p.Arg307His Uncertain significance Single submitter
- LRRC19 p.Asn121His Uncertain significance Single submitter
- LRRC19 p.Asn186Asp Uncertain significance Single submitter
- LRRC19 p.Asn200Lys Uncertain significance Single submitter
- LRRC19 p.Asn202Thr Uncertain significance Single submitter
- LRRC19 p.Asn247Lys Uncertain significance Single submitter
- LRRC19 p.Asn90Asp Uncertain significance Single submitter
- LRRC19 p.Asp53Ala Uncertain significance Single submitter
- LRRC19 p.Gly119Arg Uncertain significance Single submitter
- LRRC19 p.Gly154Asp Uncertain significance Single submitter
- LRRC19 p.Gly5Ala Uncertain significance Single submitter
- LRRC19 p.His346Tyr Uncertain significance Single submitter
- LRRC19 p.Ile16Thr Uncertain significance Single submitter
- LRRC19 p.Ile289Thr Uncertain significance Single submitter
- LRRC19 p.Ile291Val Uncertain significance Single submitter
- LRRC19 p.Ile330Thr Uncertain significance Single submitter
- LRRC19 p.Ile341Val Uncertain significance Single submitter
- LRRC19 p.Ile361Thr Uncertain significance Single submitter
- LRRC19 p.Ile8Val Uncertain significance Single submitter
- LRRC19 p.Leu88Ser Uncertain significance Single submitter
- LRRC19 p.Lys26Arg Uncertain significance Single submitter
- LRRC19 p.Phe185Tyr Uncertain significance Single submitter
- LRRC19 p.Phe320Val Uncertain significance Single submitter
- LRRC19 p.Ser108Phe Uncertain significance Single submitter
- LRRC19 p.Ser211Arg Uncertain significance Single submitter
- LRRC19 p.Ser211Asn Uncertain significance Single submitter
- LRRC19 p.Ser232Leu Uncertain significance Single submitter
- LRRC19 p.Ser325Arg Uncertain significance Single submitter
- LRRC19 p.Thr279Ser Uncertain significance Single submitter
- LRRC19 p.Thr315Ile Uncertain significance Single submitter
- LRRC19 p.Thr86Ser Uncertain significance Single submitter
- LRRC19 p.Trp11Gly Uncertain significance Single submitter
- LRRC19 p.Tyr208Ser Uncertain significance Single submitter
- LRRC19 p.Tyr215Cys Uncertain significance Single submitter
- LRRC19 p.Tyr56His Uncertain significance Single submitter
- LRRC19 p.Tyr72His Uncertain significance Single submitter
- LRRC19 p.Val142Leu Uncertain significance Single submitter
- LRRC19 p.Val276Gly Uncertain significance Single submitter
- LRRC19 p.Val29Phe Uncertain significance Single submitter
- LRRC19 p.Val350Ala Uncertain significance Single submitter
- LRRC19 p.Val85Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All LRRC19 variants
Benign 1
- p.Asn37fs Single submitter
Likely benign 9
- p.Ala271Thr Single submitter
- p.Asp351Val Single submitter ⚠
- p.Gly5Ser Single submitter
- p.Ile240= Single submitter
- p.Leu118Ser Single submitter
- p.Leu156= Single submitter
- p.Lys46Asn Single submitter
- p.Phe185Leu Single submitter
- p.Ser254Leu Single submitter
Uncertain significance 49
- p.Ala116Thr Single submitter ⚠
- p.Ala224Val Single submitter ⚠
- p.Arg106Thr Single submitter ⚠
- p.Arg307His Single submitter ⚠
- p.Asn103Ile Single submitter ⚠
- p.Asn121His Single submitter ⚠
- p.Asn186Asp Single submitter ⚠
- p.Asn200Lys Single submitter ⚠
- p.Asn202Thr Single submitter ⚠
- p.Asn247Lys Single submitter ⚠
- p.Asn90Asp Single submitter ⚠
- p.Asn90Tyr Single submitter ⚠
- p.Asp53Ala Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly154Asp Single submitter ⚠
- p.Gly5Ala Single submitter ⚠
- p.His346Tyr Single submitter ⚠
- p.Ile16Thr Single submitter ⚠
- p.Ile289Thr Single submitter ⚠
- p.Ile291Val Single submitter ⚠
- p.Ile330Thr Single submitter ⚠
- p.Ile341Val Single submitter ⚠
- p.Ile361Thr Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Leu88Ser Single submitter ⚠
- p.Lys26Arg Single submitter ⚠
- p.Phe185Tyr Single submitter ⚠
- p.Phe320Val Single submitter ⚠
- p.Ser108Phe Single submitter ⚠
- p.Ser211Arg Single submitter ⚠
- p.Ser211Asn Single submitter ⚠
- p.Ser232Leu Single submitter ⚠
- p.Ser269Ile Single submitter
- p.Ser325Arg Single submitter ⚠
- p.Thr279Ser Single submitter ⚠
- p.Thr315Ile Single submitter ⚠
- p.Thr86Ser Single submitter ⚠
- p.Trp11Gly Single submitter ⚠
- p.Tyr208Ser Single submitter ⚠
- p.Tyr215Cys Single submitter ⚠
- p.Tyr56His Single submitter ⚠
- p.Tyr72His Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val196Leu Single submitter ⚠
- p.Val276Gly Single submitter ⚠
- p.Val29Phe Single submitter ⚠
- p.Val350Ala Single submitter ⚠
- p.Val85Ala Single submitter ⚠