LRRC59 — 49 ClinVar variants
All ClinVar germline LRRC59 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 2 Likely benign · 46 Uncertain significance
Full LRRC59 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LRRC59 p.Ala260Val Uncertain significance Single submitter
- LRRC59 p.Ala287Val Uncertain significance Single submitter
- LRRC59 p.Arg162Gln Uncertain significance Single submitter
- LRRC59 p.Arg178Gln Uncertain significance Single submitter
- LRRC59 p.Arg190Gln Uncertain significance Single submitter
- LRRC59 p.Arg243His Uncertain significance Single submitter
- LRRC59 p.Arg267Gln Uncertain significance Single submitter
- LRRC59 p.Asn86His Uncertain significance Single submitter
- LRRC59 p.Asp21Val Uncertain significance Single submitter
- LRRC59 p.Asp304Asn Uncertain significance Single submitter
- LRRC59 p.Cys137Arg Uncertain significance Single submitter
- LRRC59 p.Gln152Arg Uncertain significance Single submitter
- LRRC59 p.Gln273His Uncertain significance Single submitter
- LRRC59 p.Glu29Asp Uncertain significance Single submitter
- LRRC59 p.Gly60Asp Uncertain significance Single submitter
- LRRC59 p.His241Arg Uncertain significance Single submitter
- LRRC59 p.Leu27Arg Uncertain significance Single submitter
- LRRC59 p.Lys108Arg Uncertain significance Single submitter
- LRRC59 p.Lys138Arg Uncertain significance Single submitter
- LRRC59 p.Lys172Gln Uncertain significance Single submitter
- LRRC59 p.Lys201Arg Uncertain significance Single submitter
- LRRC59 p.Pro225Leu Uncertain significance Single submitter
- LRRC59 p.Pro233Ser Uncertain significance Single submitter
- LRRC59 p.Pro237Ser Uncertain significance Single submitter
- LRRC59 p.Pro31Arg Uncertain significance Single submitter
- LRRC59 p.Ser6Gly Uncertain significance Single submitter
- LRRC59 p.Thr42Ile Uncertain significance Single submitter
- LRRC59 p.Thr52Ile Uncertain significance Single submitter
- LRRC59 p.Val259Met Uncertain significance Single submitter
- LRRC59 p.Val280Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- LRRC59 p.Ala141Thr Uncertain significance Single submitter
- LRRC59 p.Arg12Pro Uncertain significance Single submitter
- LRRC59 p.Arg157Trp Uncertain significance Single submitter
- LRRC59 p.Arg161Trp Uncertain significance Single submitter
- LRRC59 p.Arg162Trp Uncertain significance Single submitter
- LRRC59 p.Arg185Trp Uncertain significance Single submitter
- LRRC59 p.Arg188Trp Uncertain significance Single submitter
- LRRC59 p.Arg239Trp Uncertain significance Single submitter
- LRRC59 p.Arg83Cys Uncertain significance Single submitter
- LRRC59 p.Asn109Tyr Uncertain significance Single submitter
- LRRC59 p.Asn10Lys Uncertain significance Single submitter
- LRRC59 p.Gln213Pro Uncertain significance Single submitter
- LRRC59 p.Glu202Lys Uncertain significance Single submitter
- LRRC59 p.Gly258Asp Uncertain significance Single submitter
- LRRC59 p.Lys50Glu Uncertain significance Single submitter
All LRRC59 variants
Benign 1
- c.165+20G>A Single submitter
Likely benign 2
- p.Gln289Arg Single submitter
- p.Lys96Arg Single submitter
Uncertain significance 46
- p.Ala141Thr Single submitter ⚠
- p.Ala260Val Single submitter ⚠
- p.Ala287Val Single submitter ⚠
- p.Arg12Pro Single submitter ⚠
- p.Arg157Trp Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg162Trp Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg185Trp Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Asn109Tyr Single submitter ⚠
- p.Asn10Lys Single submitter ⚠
- p.Asn86His Single submitter ⚠
- p.Asp13Gly Single submitter
- p.Asp21Val Single submitter ⚠
- p.Asp304Asn Single submitter ⚠
- p.Cys137Arg Single submitter ⚠
- p.Gln152Arg Single submitter ⚠
- p.Gln213Pro Single submitter ⚠
- p.Gln273His Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Glu29Asp Single submitter ⚠
- p.Gly258Asp Single submitter ⚠
- p.Gly60Asp Single submitter ⚠
- p.His241Arg Single submitter ⚠
- p.Leu27Arg Single submitter ⚠
- p.Lys108Arg Single submitter ⚠
- p.Lys138Arg Single submitter ⚠
- p.Lys172Gln Single submitter ⚠
- p.Lys201Arg Single submitter ⚠
- p.Lys50Glu Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Pro233Ser Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Pro31Arg Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Thr42Ile Single submitter ⚠
- p.Thr52Ile Single submitter ⚠
- p.Val259Met Single submitter ⚠
- p.Val280Met Single submitter ⚠