LRRFIP1 — 137 ClinVar variants
All ClinVar germline LRRFIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 122 flagged for review →
1 Benign · 8 Likely benign · 128 Uncertain significance
Full LRRFIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 122
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 105
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LRRFIP1 c.1459+2433G>A Uncertain significance Multiple submitters
- LRRFIP1 c.1459+2437C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2445G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2511G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2514G>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2566A>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2580T>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2599G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2619G>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2655G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2670G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2691G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2692G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2695C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2704A>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2719C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2725A>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2738T>G Uncertain significance Single submitter
- LRRFIP1 c.1459+2767C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2769G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2788C>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2815G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2823G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2824C>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2842A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+2863A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+2872A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+2886G>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2890C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2907A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+2953C>G Uncertain significance Single submitter
- LRRFIP1 c.1459+2964G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+2967G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+2967G>T Uncertain significance Single submitter
- LRRFIP1 c.1459+2998A>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3039G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3051A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3066G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3109G>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3111C>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3117A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3139C>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3144G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3145A>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3149G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3211A>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3264G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3279G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3295C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3309G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3333G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3420A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3428A>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3445A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3450C>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3466A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3489G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3574C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3579G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3609G>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3669G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3684T>C Uncertain significance Single submitter
- LRRFIP1 c.1459+3705A>G Uncertain significance Single submitter
- LRRFIP1 c.1459+3708C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3750G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3763T>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3771C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3774C>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3816G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3822G>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3830G>T Uncertain significance Single submitter
- LRRFIP1 c.1459+3850C>A Uncertain significance Single submitter
- LRRFIP1 c.1459+3871G>A Uncertain significance Single submitter
- LRRFIP1 p.Ala450Thr Uncertain significance Single submitter
- LRRFIP1 p.Ala47Ser Uncertain significance Single submitter
- LRRFIP1 p.Ala99Val Uncertain significance Single submitter
- LRRFIP1 p.Arg105His Uncertain significance Single submitter
- LRRFIP1 p.Arg226His Uncertain significance Single submitter
- LRRFIP1 p.Arg36Trp Uncertain significance Single submitter
- LRRFIP1 p.Arg41Trp Uncertain significance Single submitter
-
LRRFIP1 p.Arg44His
Uncertain significance
Single submitter
myoepithelial tumor
- LRRFIP1 p.Arg51Gly Uncertain significance Single submitter
- LRRFIP1 p.Arg51His Uncertain significance Single submitter
- LRRFIP1 p.Asn268Ser Uncertain significance Single submitter
- LRRFIP1 p.Asn460Asp Uncertain significance Single submitter
- LRRFIP1 p.Asp103Gly Uncertain significance Single submitter
- LRRFIP1 p.Asp276Asn Uncertain significance Single submitter
- LRRFIP1 p.Asp457Asn Uncertain significance Single submitter
- LRRFIP1 p.Asp483His Uncertain significance Single submitter
- LRRFIP1 p.Glu102Lys Uncertain significance Single submitter
- LRRFIP1 p.Glu312Val Uncertain significance Single submitter
- LRRFIP1 p.Glu377Lys Uncertain significance Single submitter
- LRRFIP1 p.Gly249Arg Uncertain significance Single submitter
- LRRFIP1 p.Gly484Glu Uncertain significance Single submitter
- LRRFIP1 p.Ile255Val Uncertain significance Single submitter
- LRRFIP1 p.Ile261Phe Uncertain significance Single submitter
- LRRFIP1 p.Leu376Arg Uncertain significance Single submitter
- LRRFIP1 p.Leu478Pro Uncertain significance Single submitter
- LRRFIP1 p.Leu55Pro Uncertain significance Single submitter
- LRRFIP1 p.Met228Lys Uncertain significance Single submitter
- LRRFIP1 p.Met303Val Uncertain significance Single submitter
- LRRFIP1 p.Met326Val Uncertain significance Single submitter
- LRRFIP1 p.Ser456Cys Uncertain significance Single submitter
- LRRFIP1 p.Ser93Phe Uncertain significance Single submitter
- LRRFIP1 p.Thr481Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- LRRFIP1 p.Ala38Thr Uncertain significance Single submitter
- LRRFIP1 p.Ala42Val Uncertain significance Single submitter
- LRRFIP1 p.Ala45Thr Uncertain significance Single submitter
- LRRFIP1 p.Arg88Cys Uncertain significance Single submitter
- LRRFIP1 p.Asn452Lys Uncertain significance Single submitter
- LRRFIP1 p.Gln333Arg Uncertain significance Single submitter
- LRRFIP1 p.Gln340Arg Uncertain significance Single submitter
- LRRFIP1 p.Glu49Lys Uncertain significance Single submitter
- LRRFIP1 p.Gly109Asp Uncertain significance Single submitter
- LRRFIP1 p.Gly279Arg Uncertain significance Single submitter
- LRRFIP1 p.His355Asn Uncertain significance Single submitter
- LRRFIP1 p.Leu330Ile Uncertain significance Single submitter
- LRRFIP1 p.Lys301Arg Uncertain significance Single submitter
- LRRFIP1 p.Lys53Thr Uncertain significance Single submitter
- LRRFIP1 p.Met52Ile Uncertain significance Single submitter
- LRRFIP1 p.Ser356Arg Uncertain significance Single submitter
- LRRFIP1 p.Ser93Cys Uncertain significance Single submitter
All LRRFIP1 variants
Benign 1
- p.Ser260= Multiple submitters
Likely benign 8
- c.1459+3019A>G Single submitter
- c.1459+3038C>T Single submitter
- c.1459+3380C>T Single submitter
- c.1459+3487G>A Single submitter
- c.1459+3611A>C Single submitter
- c.1459+3681C>A Single submitter
- c.1459+3753A>G Single submitter
- p.Tyr341= Single submitter
Uncertain significance 128
- c.1459+2433G>A Multiple submitters ⚠
- c.1459+2437C>T Single submitter ⚠
- c.1459+2445G>A Single submitter ⚠
- c.1459+2511G>A Single submitter ⚠
- c.1459+2514G>T Single submitter ⚠
- c.1459+2566A>C Single submitter ⚠
- c.1459+2580T>C Single submitter ⚠
- c.1459+2599G>A Single submitter ⚠
- c.1459+2619G>T Single submitter ⚠
- c.1459+2655G>A Single submitter ⚠
- c.1459+2670G>A Single submitter ⚠
- c.1459+2691G>C Single submitter ⚠
- c.1459+2692G>A Single submitter ⚠
- c.1459+2695C>T Single submitter ⚠
- c.1459+2704A>T Single submitter ⚠
- c.1459+2719C>T Single submitter ⚠
- c.1459+2725A>C Single submitter ⚠
- c.1459+2738T>G Single submitter ⚠
- c.1459+2767C>T Single submitter ⚠
- c.1459+2769G>C Single submitter ⚠
- c.1459+2788C>A Single submitter ⚠
- c.1459+2815G>A Single submitter ⚠
- c.1459+2823G>C Single submitter ⚠
- c.1459+2824C>A Single submitter ⚠
- c.1459+2842A>G Single submitter ⚠
- c.1459+2863A>G Single submitter ⚠
- c.1459+2872A>G Single submitter ⚠
- c.1459+2886G>T Single submitter ⚠
- c.1459+2890C>T Single submitter ⚠
- c.1459+2907A>G Single submitter ⚠
- c.1459+2953C>G Single submitter ⚠
- c.1459+2964G>A Single submitter ⚠
- c.1459+2967G>C Single submitter ⚠
- c.1459+2967G>T Single submitter ⚠
- c.1459+2998A>T Single submitter ⚠
- c.1459+3039G>A Single submitter ⚠
- c.1459+3051A>G Single submitter ⚠
- c.1459+3066G>C Single submitter ⚠
- c.1459+3109G>T Single submitter ⚠
- c.1459+3111C>G Single submitter ⚠
- c.1459+3117A>G Single submitter ⚠
- c.1459+3139C>G Single submitter ⚠
- c.1459+3144G>C Single submitter ⚠
- c.1459+3145A>T Single submitter ⚠
- c.1459+3149G>A Single submitter ⚠
- c.1459+3211A>C Single submitter ⚠
- c.1459+3264G>A Single submitter ⚠
- c.1459+3279G>A Single submitter ⚠
- c.1459+3295C>T Single submitter ⚠
- c.1459+3309G>A Single submitter ⚠
- c.1459+3333G>A Single submitter ⚠
- c.1459+3420A>G Single submitter ⚠
- c.1459+3428A>C Single submitter ⚠
- c.1459+3445A>G Single submitter ⚠
- c.1459+3450C>A Single submitter ⚠
- c.1459+3466A>G Single submitter ⚠
- c.1459+3489G>A Single submitter ⚠
- c.1459+3574C>T Single submitter ⚠
- c.1459+3579G>C Single submitter ⚠
- c.1459+3609G>C Single submitter ⚠
- c.1459+3669G>A Single submitter ⚠
- c.1459+3684T>C Single submitter ⚠
- c.1459+3705A>G Single submitter ⚠
- c.1459+3708C>T Single submitter ⚠
- c.1459+3750G>A Single submitter ⚠
- c.1459+3763T>A Single submitter ⚠
- c.1459+3771C>T Single submitter ⚠
- c.1459+3774C>T Single submitter ⚠
- c.1459+3816G>A Single submitter ⚠
- c.1459+3822G>A Single submitter ⚠
- c.1459+3830G>T Single submitter ⚠
- c.1459+3850C>A Single submitter ⚠
- c.1459+3871G>A Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Ala42Val Single submitter ⚠
- p.Ala450Thr Single submitter ⚠
- p.Ala45Thr Single submitter ⚠
- p.Ala47Ser Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg44His Single submitter myoepithelial tumor ⚠
- p.Arg51Gly Single submitter ⚠
- p.Arg51His Single submitter ⚠
- p.Arg88Cys Single submitter ⚠
- p.Asn268Ser Single submitter ⚠
- p.Asn452Lys Single submitter ⚠
- p.Asn460Asp Single submitter ⚠
- p.Asp103Gly Single submitter ⚠
- p.Asp276Asn Single submitter ⚠
- p.Asp457Asn Single submitter ⚠
- p.Asp483His Single submitter ⚠
- p.Gln273Arg Single submitter
- p.Gln333Arg Single submitter ⚠
- p.Gln340Arg Single submitter ⚠
- p.Gln361Arg Single submitter
- p.Glu102Lys Single submitter ⚠
- p.Glu312Val Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu49Lys Single submitter ⚠
- p.Gly109Asp Single submitter ⚠
- p.Gly249Arg Single submitter ⚠
- p.Gly279Arg Single submitter ⚠
- p.Gly484Glu Single submitter ⚠
- p.His355Asn Single submitter ⚠
- p.Ile255Val Single submitter ⚠
- p.Ile261Phe Single submitter ⚠
- p.Leu330Ile Single submitter ⚠
- p.Leu376Arg Single submitter ⚠
- p.Leu478Pro Single submitter ⚠
- p.Leu552Pro Single submitter
- p.Leu55Pro Single submitter ⚠
- p.Leu636Phe Single submitter
- p.Lys301Arg Single submitter ⚠
- p.Lys53Thr Single submitter ⚠
- p.Met228Lys Single submitter ⚠
- p.Met303Val Single submitter ⚠
- p.Met326Val Single submitter ⚠
- p.Met52Ile Single submitter ⚠
- p.Pro125fs Single submitter
- p.Ser356Arg Single submitter ⚠
- p.Ser456Cys Single submitter ⚠
- p.Ser93Cys Single submitter ⚠
- p.Ser93Phe Single submitter ⚠
- p.Thr235Met Single submitter
- p.Thr481Ile Single submitter ⚠