LRRTM3 — 51 ClinVar variants
All ClinVar germline LRRTM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 49 Uncertain significance
Full LRRTM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LRRTM3 p.Ala372Ser Uncertain significance Single submitter
- LRRTM3 p.Ala401Ser Uncertain significance Single submitter
- LRRTM3 p.Ala581Thr Uncertain significance Single submitter
- LRRTM3 p.Arg109His Uncertain significance Single submitter
- LRRTM3 p.Arg282Leu Uncertain significance Single submitter
- LRRTM3 p.Arg460Lys Uncertain significance Single submitter
- LRRTM3 p.Arg572Gln Uncertain significance Single submitter
- LRRTM3 p.Asn288Ser Uncertain significance Single submitter
- LRRTM3 p.Glu31Gln Uncertain significance Single submitter
- LRRTM3 p.Glu407Val Uncertain significance Single submitter
- LRRTM3 p.Glu413Asp Uncertain significance Single submitter
- LRRTM3 p.Gly362Asp Uncertain significance Single submitter
- LRRTM3 p.Gly83Glu Uncertain significance Single submitter
- LRRTM3 p.His146Tyr Uncertain significance Single submitter
- LRRTM3 p.His557Gln Uncertain significance Single submitter
- LRRTM3 p.His557Tyr Uncertain significance Single submitter
- LRRTM3 p.Ile438Asn Uncertain significance Single submitter
- LRRTM3 p.Leu290Arg Uncertain significance Single submitter
- LRRTM3 p.Leu8Pro Uncertain significance Single submitter
- LRRTM3 p.Lys77Asn Uncertain significance Single submitter
- LRRTM3 p.Pro131Thr Uncertain significance Single submitter
- LRRTM3 p.Pro393Leu Uncertain significance Single submitter
- LRRTM3 p.Pro394Leu Uncertain significance Single submitter
- LRRTM3 p.Pro396Leu Uncertain significance Single submitter
- LRRTM3 p.Pro397Thr Uncertain significance Single submitter
- LRRTM3 p.Pro56Thr Uncertain significance Single submitter
- LRRTM3 p.Ser10Arg Uncertain significance Single submitter
- LRRTM3 p.Ser322Phe Uncertain significance Single submitter
- LRRTM3 p.Ser391Gly Uncertain significance Single submitter
- LRRTM3 p.Ser506Leu Uncertain significance Single submitter
- LRRTM3 p.Thr21Ala Uncertain significance Single submitter
- LRRTM3 p.Thr379Arg Uncertain significance Single submitter
- LRRTM3 p.Thr547Met Uncertain significance Single submitter
- LRRTM3 p.Thr553Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- LRRTM3 p.Ala223Val Uncertain significance Single submitter
- LRRTM3 p.Arg109Cys Uncertain significance Single submitter
- LRRTM3 p.Arg444Leu Uncertain significance Single submitter
- LRRTM3 p.Asn85Lys Uncertain significance Single submitter
- LRRTM3 p.Cys533Arg Uncertain significance Single submitter
- LRRTM3 p.Gln451Pro Uncertain significance Single submitter
- LRRTM3 p.Glu510Lys Uncertain significance Single submitter
- LRRTM3 p.Gly37Cys Uncertain significance Single submitter
- LRRTM3 p.Phe417Ser Uncertain significance Single submitter
- LRRTM3 p.Ser303Phe Uncertain significance Single submitter
- LRRTM3 p.Thr128Ile Uncertain significance Single submitter
All LRRTM3 variants
Uncertain significance 49
- p.Ala223Val Single submitter ⚠
- p.Ala372Ser Single submitter ⚠
- p.Ala401Ser Single submitter ⚠
- p.Ala581Thr Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg109His Single submitter ⚠
- p.Arg282Leu Single submitter ⚠
- p.Arg444Leu Single submitter ⚠
- p.Arg460Lys Single submitter ⚠
- p.Arg572Gln Single submitter ⚠
- p.Asn288Ser Single submitter ⚠
- p.Asn85Lys Single submitter ⚠
- p.Asp353His Single submitter
- p.Cys533Arg Single submitter ⚠
- p.Gln232Ter Single submitter
- p.Gln451Pro Single submitter ⚠
- p.Glu31Gln Single submitter ⚠
- p.Glu407Val Single submitter ⚠
- p.Glu413Asp Single submitter ⚠
- p.Glu510Lys Single submitter ⚠
- p.Gly362Asp Single submitter ⚠
- p.Gly37Cys Single submitter ⚠
- p.Gly83Glu Single submitter ⚠
- p.His146Tyr Single submitter ⚠
- p.His557Gln Single submitter ⚠
- p.His557Tyr Single submitter ⚠
- p.Ile438Asn Single submitter ⚠
- p.Leu290Arg Single submitter ⚠
- p.Leu436Met Single submitter
- p.Leu8Pro Single submitter ⚠
- p.Lys77Asn Single submitter ⚠
- p.Phe417Ser Single submitter ⚠
- p.Pro131Thr Single submitter ⚠
- p.Pro393Leu Single submitter ⚠
- p.Pro394Leu Single submitter ⚠
- p.Pro396Leu Single submitter ⚠
- p.Pro397Thr Single submitter ⚠
- p.Pro56Thr Single submitter ⚠
- p.Ser10Arg Single submitter ⚠
- p.Ser303Phe Single submitter ⚠
- p.Ser322Phe Single submitter ⚠
- p.Ser391Gly Single submitter ⚠
- p.Ser506Leu Single submitter ⚠
- p.Thr128Ile Single submitter ⚠
- p.Thr21Ala Single submitter ⚠
- p.Thr379Arg Single submitter ⚠
- p.Thr547Met Single submitter ⚠
- p.Thr553Met Single submitter ⚠
- p.Val425Met Single submitter