LSM12 — 12 ClinVar variants
All ClinVar germline LSM12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Likely benign · 11 Uncertain significance
Full LSM12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LSM12 p.Arg92Trp Uncertain significance Single submitter
- LSM12 p.Asn51Ser Uncertain significance Single submitter
- LSM12 p.Gln61Lys Uncertain significance Single submitter
- LSM12 p.His52Arg Uncertain significance Single submitter
- LSM12 p.Ile105Val Uncertain significance Single submitter
- LSM12 p.Pro4Ser Uncertain significance Single submitter
- LSM12 p.Thr73Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All LSM12 variants
Likely benign 1
- p.Thr123= Single submitter
Uncertain significance 11
- p.Arg163Cys Single submitter ⚠
- p.Arg181Cys Single submitter ⚠
- p.Arg24Pro Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asn51Ser Single submitter ⚠
- p.Gln61Lys Single submitter ⚠
- p.His52Arg Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Phe170Leu Single submitter ⚠
- p.Pro4Ser Single submitter ⚠
- p.Thr73Ala Single submitter ⚠