LSM14A — 45 ClinVar variants
All ClinVar germline LSM14A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Likely benign · 43 Uncertain significance
Full LSM14A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LSM14A c.1369-950C>T Uncertain significance Single submitter
- LSM14A p.Ala161Gly Uncertain significance Single submitter
- LSM14A p.Ala161Val Uncertain significance Single submitter
- LSM14A p.Ala202Thr Uncertain significance Single submitter
- LSM14A p.Ala264Val Uncertain significance Single submitter
- LSM14A p.Arg181His Uncertain significance Single submitter
- LSM14A p.Arg285Gln Uncertain significance Single submitter
- LSM14A p.Arg435Gln Uncertain significance Single submitter
- LSM14A p.Asn350His Uncertain significance Single submitter
- LSM14A p.Asp169Gly Uncertain significance Single submitter
- LSM14A p.Asp255Gly Uncertain significance Single submitter
- LSM14A p.Asp255His Uncertain significance Single submitter
- LSM14A p.Asp352Asn Uncertain significance Single submitter
- LSM14A p.Gln122His Uncertain significance Single submitter
- LSM14A p.Gln168Arg Uncertain significance Single submitter
- LSM14A p.Gln176Glu Uncertain significance Single submitter
- LSM14A p.Gln84Arg Uncertain significance Single submitter
- LSM14A p.Glu250Gln Uncertain significance Single submitter
- LSM14A p.Leu128Phe Uncertain significance Single submitter
- LSM14A p.Met195Val Uncertain significance Single submitter
- LSM14A p.Ser141Gly Uncertain significance Single submitter
- LSM14A p.Ser172Cys Uncertain significance Single submitter
- LSM14A p.Thr170Ile Uncertain significance Single submitter
- LSM14A p.Thr194Ala Uncertain significance Single submitter
- LSM14A p.Val218Leu Uncertain significance Single submitter
- LSM14A p.Val61Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- LSM14A p.Ala386Thr Uncertain significance Single submitter
- LSM14A p.Arg276Gln Uncertain significance Single submitter
- LSM14A p.Arg381Gln Uncertain significance Single submitter
- LSM14A p.Arg406Cys Uncertain significance Single submitter
- LSM14A p.Arg406His Uncertain significance Single submitter
- LSM14A p.Arg423Cys Uncertain significance Single submitter
- LSM14A p.Arg438Ser Uncertain significance Single submitter
- LSM14A p.Arg445His Uncertain significance Single submitter
- LSM14A p.Arg456Thr Uncertain significance Single submitter
- LSM14A p.Asp339His Uncertain significance Single submitter
- LSM14A p.Gly419Ser Uncertain significance Single submitter
- LSM14A p.Gly428Val Uncertain significance Single submitter
- LSM14A p.Gly446Arg Uncertain significance Single submitter
- LSM14A p.Met108Lys Uncertain significance Single submitter
- LSM14A p.Pro399Ser Uncertain significance Single submitter
- LSM14A p.Thr76Asn Uncertain significance Single submitter
- LSM14A p.Val342Asp Uncertain significance Single submitter
All LSM14A variants
Likely benign 2
- p.Asn256Ser Single submitter
- p.Ser10= Single submitter
Uncertain significance 43
- c.1369-950C>T Single submitter ⚠
- p.Ala161Gly Single submitter ⚠
- p.Ala161Val Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala386Thr Single submitter ⚠
- p.Arg181His Single submitter ⚠
- p.Arg276Gln Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg406Cys Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg423Cys Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Arg438Ser Single submitter ⚠
- p.Arg445His Single submitter ⚠
- p.Arg456Thr Single submitter ⚠
- p.Asn350His Single submitter ⚠
- p.Asp169Gly Single submitter ⚠
- p.Asp255Gly Single submitter ⚠
- p.Asp255His Single submitter ⚠
- p.Asp339His Single submitter ⚠
- p.Asp352Asn Single submitter ⚠
- p.Gln122His Single submitter ⚠
- p.Gln168Arg Single submitter ⚠
- p.Gln176Glu Single submitter ⚠
- p.Gln84Arg Single submitter ⚠
- p.Glu250Gln Single submitter ⚠
- p.Gly419Ser Single submitter ⚠
- p.Gly428Val Single submitter ⚠
- p.Gly446Arg Single submitter ⚠
- p.Leu128Phe Single submitter ⚠
- p.Met108Lys Single submitter ⚠
- p.Met195Val Single submitter ⚠
- p.Pro399Ser Single submitter ⚠
- p.Ser141Gly Single submitter ⚠
- p.Ser172Cys Single submitter ⚠
- p.Thr170Ile Single submitter ⚠
- p.Thr194Ala Single submitter ⚠
- p.Thr76Asn Single submitter ⚠
- p.Val218Leu Single submitter ⚠
- p.Val342Asp Single submitter ⚠
- p.Val61Ile Single submitter ⚠