Sugi Variant

Sugi Variant/LSS

LSS — 371 ClinVar variants

All ClinVar germline LSS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 133 flagged for review →

18 Pathogenic · 2 Pathogenic/Likely pathogenic · 12 Likely pathogenic · 5 Conflicting · 72 Benign · 12 Benign/Likely benign · 102 Likely benign · 148 Uncertain significance

Full LSS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 133

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 95

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All LSS variants

Pathogenic 18

Pathogenic/Likely pathogenic 2

Likely pathogenic 12

Conflicting classifications of pathogenicity 5

Benign 72

Benign/Likely benign 12

Likely benign 102

Uncertain significance 148