LTA — 12 ClinVar variants
All ClinVar germline LTA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Benign · 1 Likely benign · 10 Uncertain significance
Full LTA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LTA p.Ala171Thr Uncertain significance Single submitter
- LTA p.Gln141Pro Uncertain significance Single submitter
- LTA p.Gly91Arg Uncertain significance Single submitter
- LTA p.His51Asn Uncertain significance Single submitter
- LTA p.Ile106Val Uncertain significance Single submitter
- LTA p.Leu35Ile Uncertain significance Single submitter
- LTA p.Lys53Arg Uncertain significance Single submitter
- LTA p.Thr60Ala Uncertain significance Single submitter
- LTA p.Thr83Met Uncertain significance Single submitter
- LTA p.Val109Ile Uncertain significance Single submitter
All LTA variants
Benign 1
- p.Cys13Arg No assertion criteria LTA-related disorder
Likely benign 1
- p.Ala64= No assertion criteria LTA-related disorder
Uncertain significance 10
- p.Ala171Thr Single submitter ⚠
- p.Gln141Pro Single submitter ⚠
- p.Gly91Arg Single submitter ⚠
- p.His51Asn Single submitter ⚠
- p.Ile106Val Single submitter ⚠
- p.Leu35Ile Single submitter ⚠
- p.Lys53Arg Single submitter ⚠
- p.Thr60Ala Single submitter ⚠
- p.Thr83Met Single submitter ⚠
- p.Val109Ile Single submitter ⚠