LTA4H — 64 ClinVar variants
All ClinVar germline LTA4H variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
4 Benign · 1 Benign/Likely benign · 4 Likely benign · 55 Uncertain significance
Full LTA4H gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LTA4H p.Ala204Val Uncertain significance Single submitter
- LTA4H p.Ala479Thr Uncertain significance Single submitter
- LTA4H p.Ala479Val Uncertain significance Single submitter
- LTA4H p.Ala555Val Uncertain significance Single submitter
- LTA4H p.Arg175His Uncertain significance Single submitter
- LTA4H p.Arg327His Uncertain significance Single submitter
- LTA4H p.Arg332Gln Uncertain significance Single submitter
- LTA4H p.Arg520Gln Uncertain significance Single submitter
- LTA4H p.Arg569Trp Uncertain significance Single submitter
- LTA4H p.Arg587Gln Uncertain significance Single submitter
- LTA4H p.Asp423Glu Uncertain significance Single submitter
- LTA4H p.Glu239Val Uncertain significance Single submitter
- LTA4H p.Glu402Asp Uncertain significance Single submitter
- LTA4H p.Glu481Lys Uncertain significance Single submitter
- LTA4H p.Leu116Phe Uncertain significance Single submitter
- LTA4H p.Leu155Ser Uncertain significance Single submitter
- LTA4H p.Leu170Ile Uncertain significance Single submitter
- LTA4H p.Leu333Ser Uncertain significance Single submitter
- LTA4H p.Leu366Val Uncertain significance Single submitter
- LTA4H p.Leu398His Uncertain significance Single submitter
- LTA4H p.Leu554Phe Uncertain significance Single submitter
- LTA4H p.Lys414Thr Uncertain significance Single submitter
- LTA4H p.Lys426Arg Uncertain significance Single submitter
- LTA4H p.Met87Val Uncertain significance Single submitter
- LTA4H p.Phe266Val Uncertain significance Single submitter
- LTA4H p.Pro182Leu Uncertain significance Single submitter
- LTA4H p.Pro512Ser Uncertain significance Single submitter
- LTA4H p.Ser223Cys Uncertain significance Single submitter
- LTA4H p.Ser223Phe Uncertain significance Single submitter
- LTA4H p.Ser90Phe Uncertain significance Single submitter
- LTA4H p.Thr560Ala Uncertain significance Single submitter
- LTA4H p.Thr57Ser Uncertain significance Single submitter
- LTA4H p.Thr588Ser Uncertain significance Single submitter
- LTA4H p.Tyr417Cys Uncertain significance Single submitter
- LTA4H p.Tyr74His Uncertain significance Single submitter
- LTA4H p.Val168Leu Uncertain significance Single submitter
- LTA4H p.Val604Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- LTA4H p.Ala285Val Uncertain significance Single submitter
- LTA4H p.Arg541Gln Uncertain significance Single submitter
- LTA4H p.Asp176Gly Uncertain significance Single submitter
- LTA4H p.Asp574Tyr Uncertain significance Single submitter
- LTA4H p.Gly77Val Uncertain significance Single submitter
- LTA4H p.Ile103Met Uncertain significance Single submitter
- LTA4H p.Pro375His Uncertain significance Single submitter
- LTA4H p.Ser85Leu Uncertain significance Single submitter
- LTA4H p.Thr124Ser Uncertain significance Single submitter
- LTA4H p.Thr490Pro Uncertain significance Single submitter
- LTA4H p.Tyr432Cys Uncertain significance Single submitter
- LTA4H p.Val599Leu Uncertain significance Single submitter
- LTA4H p.Val604Ala Uncertain significance Single submitter
- LTA4H p.Val65Ala Uncertain significance Single submitter
All LTA4H variants
Benign 4
- c.290+9G>C Multiple submitters
- p.Glu481Asp Multiple submitters
- p.Tyr268= Multiple submitters
- p.Tyr450= Multiple submitters
Benign/Likely benign 1
- p.Gly358= Multiple submitters
Likely benign 4
- p.Ala94Thr Multiple submitters
- p.Arg510Lys Single submitter
- p.Asn488Ser Single submitter
- p.Cys330= Single submitter
Uncertain significance 55
- p.Ala204Val Single submitter ⚠
- p.Ala285Val Single submitter ⚠
- p.Ala479Thr Single submitter ⚠
- p.Ala479Val Single submitter ⚠
- p.Ala555Val Single submitter ⚠
- p.Arg175His Single submitter ⚠
- p.Arg327His Single submitter ⚠
- p.Arg332Gln Single submitter ⚠
- p.Arg520Gln Single submitter ⚠
- p.Arg541Gln Single submitter ⚠
- p.Arg569Trp Single submitter ⚠
- p.Arg587Gln Single submitter ⚠
- p.Asp176Gly Single submitter ⚠
- p.Asp423Glu Single submitter ⚠
- p.Asp574Tyr Single submitter ⚠
- p.Glu239Val Single submitter ⚠
- p.Glu402Asp Single submitter ⚠
- p.Glu481Lys Single submitter ⚠
- p.Gly69Val Single submitter
- p.Gly77Val Single submitter ⚠
- p.Ile103Met Single submitter ⚠
- p.Leu116Phe Single submitter ⚠
- p.Leu155Ser Single submitter ⚠
- p.Leu170Ile Single submitter ⚠
- p.Leu333Ser Single submitter ⚠
- p.Leu366Val Single submitter ⚠
- p.Leu398His Single submitter ⚠
- p.Leu504Phe Single submitter
- p.Leu554Phe Single submitter ⚠
- p.Lys414Thr Single submitter ⚠
- p.Lys426Arg Single submitter ⚠
- p.Met87Val Single submitter ⚠
- p.Phe266Val Single submitter ⚠
- p.Pro182Leu Single submitter ⚠
- p.Pro375His Single submitter ⚠
- p.Pro512Ser Single submitter ⚠
- p.Ser223Cys Single submitter ⚠
- p.Ser223Phe Single submitter ⚠
- p.Ser85Leu Single submitter ⚠
- p.Ser90Phe Single submitter ⚠
- p.Thr124Ser Single submitter ⚠
- p.Thr156Asn Single submitter
- p.Thr490Pro Single submitter ⚠
- p.Thr560Ala Single submitter ⚠
- p.Thr57Ser Single submitter ⚠
- p.Thr588Ser Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Tyr432Cys Single submitter ⚠
- p.Tyr74His Single submitter ⚠
- p.Val168Leu Single submitter ⚠
- p.Val367Ala Single submitter
- p.Val599Leu Single submitter ⚠
- p.Val604Ala Single submitter ⚠
- p.Val604Leu Single submitter ⚠
- p.Val65Ala Single submitter ⚠