LTB4R — 46 ClinVar variants
All ClinVar germline LTB4R variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 4 Likely benign · 40 Uncertain significance
Full LTB4R gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LTB4R p.Ala103Thr Uncertain significance Single submitter
- LTB4R p.Ala286Thr Uncertain significance Single submitter
- LTB4R p.Ala30Ser Uncertain significance Single submitter
- LTB4R p.Ala325Pro Uncertain significance Single submitter
- LTB4R p.Ala330Asp Uncertain significance Single submitter
- LTB4R p.Ala330Thr Uncertain significance Single submitter
- LTB4R p.Ala331Thr Uncertain significance Single submitter
- LTB4R p.Ala342Pro Uncertain significance Single submitter
- LTB4R p.Arg214His Uncertain significance Single submitter
- LTB4R p.Gln80Glu Uncertain significance Single submitter
- LTB4R p.Gly140Ala Uncertain significance Single submitter
- LTB4R p.Gly297Val Uncertain significance Single submitter
- LTB4R p.Gly98Ala Uncertain significance Single submitter
- LTB4R p.Ile204Thr Uncertain significance Single submitter
- LTB4R p.Ile226Val Uncertain significance Single submitter
- LTB4R p.Ile227Val Uncertain significance Single submitter
- LTB4R p.Leu258Val Uncertain significance Single submitter
- LTB4R p.Leu69Arg Uncertain significance Single submitter
- LTB4R p.Lys45Thr Uncertain significance Single submitter
- LTB4R p.Met133Leu Uncertain significance Single submitter
- LTB4R p.Phe146Leu Uncertain significance Single submitter
- LTB4R p.Phe230Leu Uncertain significance Single submitter
- LTB4R p.Phe300Cys Uncertain significance Single submitter
- LTB4R p.Pro9Thr Uncertain significance Single submitter
- LTB4R p.Ser202Trp Uncertain significance Single submitter
- LTB4R p.Ser279Arg Uncertain significance Single submitter
- LTB4R p.Thr130Ser Uncertain significance Single submitter
- LTB4R p.Thr163Arg Uncertain significance Single submitter
- LTB4R p.Thr308Arg Uncertain significance Single submitter
- LTB4R p.Thr324Ser Uncertain significance Single submitter
- LTB4R p.Thr3Ile Uncertain significance Single submitter
- LTB4R p.Trp83Cys Uncertain significance Single submitter
- LTB4R p.Val14Ile Uncertain significance Single submitter
- LTB4R p.Val239Met Uncertain significance Single submitter
- LTB4R p.Val298Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All LTB4R variants
Benign 2
- p.Ala118= Multiple submitters
- p.Ala79Ser Single submitter
Likely benign 4
- p.Asn268Ser Single submitter
- p.Leu332Pro Single submitter
- p.Met56Leu Single submitter
- p.Ser18Phe Single submitter
Uncertain significance 40
- p.Ala103Thr Single submitter ⚠
- p.Ala286Thr Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Ala325Pro Single submitter ⚠
- p.Ala330Asp Single submitter ⚠
- p.Ala330Thr Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Ala342Pro Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Gln80Glu Single submitter ⚠
- p.Gly140Ala Single submitter ⚠
- p.Gly251Ala Single submitter ⚠
- p.Gly260Arg Single submitter ⚠
- p.Gly297Val Single submitter ⚠
- p.Gly98Ala Single submitter ⚠
- p.Ile204Thr Single submitter ⚠
- p.Ile226Val Single submitter ⚠
- p.Ile227Val Single submitter ⚠
- p.Leu258Val Single submitter ⚠
- p.Leu69Arg Single submitter ⚠
- p.Lys45Thr Single submitter ⚠
- p.Met133Leu Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Phe230Leu Single submitter ⚠
- p.Phe300Cys Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser112Gly Single submitter ⚠
- p.Ser202Trp Single submitter ⚠
- p.Ser279Arg Single submitter ⚠
- p.Ser6Phe Single submitter ⚠
- p.Thr130Ser Single submitter ⚠
- p.Thr163Arg Single submitter ⚠
- p.Thr308Arg Single submitter ⚠
- p.Thr324Ser Single submitter ⚠
- p.Thr3Ile Single submitter ⚠
- p.Trp83Cys Single submitter ⚠
- p.Val14Ile Single submitter ⚠
- p.Val239Met Single submitter ⚠
- p.Val298Leu Single submitter ⚠