LTB4R2 — 79 ClinVar variants
All ClinVar germline LTB4R2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
2 Benign · 77 Uncertain significance
Full LTB4R2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LTB4R2 p.Ala102Thr Uncertain significance Single submitter
- LTB4R2 p.Ala129Ser Uncertain significance Single submitter
- LTB4R2 p.Ala189Val Uncertain significance Single submitter
- LTB4R2 p.Ala268Thr Uncertain significance Single submitter
- LTB4R2 p.Ala65Val Uncertain significance Single submitter
- LTB4R2 p.Ala70Thr Uncertain significance Single submitter
- LTB4R2 p.Ala70Val Uncertain significance Single submitter
- LTB4R2 p.Arg52Gln Uncertain significance Single submitter
- LTB4R2 p.Asn342Ser Uncertain significance Single submitter
- LTB4R2 p.Cys4Tyr Uncertain significance Single submitter
- LTB4R2 p.Gly113Ala Uncertain significance Single submitter
- LTB4R2 p.Gly113Cys Uncertain significance Single submitter
- LTB4R2 p.Gly216Arg Uncertain significance Single submitter
- LTB4R2 p.Gly316Arg Uncertain significance Single submitter
- LTB4R2 p.Gly353Arg Uncertain significance Single submitter
- LTB4R2 p.His181Leu Uncertain significance Single submitter
- LTB4R2 p.Leu236Arg Uncertain significance Single submitter
- LTB4R2 p.Leu236Pro Uncertain significance Single submitter
- LTB4R2 p.Met105Leu Uncertain significance Single submitter
- LTB4R2 p.Pro126Ser Uncertain significance Single submitter
- LTB4R2 p.Pro155Leu Uncertain significance Single submitter
- LTB4R2 p.Pro193Thr Uncertain significance Single submitter
- LTB4R2 p.Pro285Gln Uncertain significance Single submitter
- LTB4R2 p.Pro331Arg Uncertain significance Single submitter
- LTB4R2 p.Pro331Leu Uncertain significance Single submitter
- LTB4R2 p.Pro76Gln Uncertain significance Single submitter
- LTB4R2 p.Pro7Ala Uncertain significance Single submitter
- LTB4R2 p.Ser215Pro Uncertain significance Single submitter
- LTB4R2 p.Ser282Cys Uncertain significance Single submitter
- LTB4R2 p.Thr186Ser Uncertain significance Single submitter
- LTB4R2 p.Thr22Ile Uncertain significance Single submitter
- LTB4R2 p.Trp146Ser Uncertain significance Single submitter
- LTB4R2 p.Trp16Cys Uncertain significance Single submitter
- LTB4R2 p.Trp356Arg Uncertain significance Single submitter
- LTB4R2 p.Val154Leu Uncertain significance Single submitter
- LTB4R2 p.Val41Leu Uncertain significance Single submitter
- LTB4R2 p.Val42Ala Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- LTB4R2 p.Ala144Thr Uncertain significance Single submitter
- LTB4R2 p.Ala156Val Uncertain significance Single submitter
- LTB4R2 p.Ala157Val Uncertain significance Single submitter
- LTB4R2 p.Ala178Thr Uncertain significance Single submitter
- LTB4R2 p.Ala265Thr Uncertain significance Single submitter
- LTB4R2 p.Ala57Val Uncertain significance Single submitter
- LTB4R2 p.Arg131Gln Uncertain significance Single submitter
- LTB4R2 p.Arg131Trp Uncertain significance Single submitter
- LTB4R2 p.Arg20Trp Uncertain significance Single submitter
- LTB4R2 p.Arg217Gln Uncertain significance Single submitter
- LTB4R2 p.Arg306Trp Uncertain significance Single submitter
- LTB4R2 p.Arg340His Uncertain significance Single submitter
- LTB4R2 p.Arg52Pro Uncertain significance Single submitter
- LTB4R2 p.Asp294Asn Uncertain significance Single submitter
- LTB4R2 p.Glu185Gln Uncertain significance Single submitter
- LTB4R2 p.Gly199Ser Uncertain significance Single submitter
- LTB4R2 p.Gly214Cys Uncertain significance Single submitter
- LTB4R2 p.Gly257Glu Uncertain significance Single submitter
- LTB4R2 p.Gly318Asp Uncertain significance Single submitter
- LTB4R2 p.Leu152Phe Uncertain significance Single submitter
- LTB4R2 p.Leu245Phe Uncertain significance Single submitter
- LTB4R2 p.Leu246Gln Uncertain significance Single submitter
- LTB4R2 p.Leu246Pro Uncertain significance Single submitter
- LTB4R2 p.Leu262Pro Uncertain significance Single submitter
- LTB4R2 p.Leu56Pro Uncertain significance Single submitter
- LTB4R2 p.Leu89Arg Uncertain significance Single submitter
- LTB4R2 p.Pro130Leu Uncertain significance Single submitter
- LTB4R2 p.Pro135Leu Uncertain significance Single submitter
- LTB4R2 p.Pro135Ser Uncertain significance Single submitter
- LTB4R2 p.Pro254Ser Uncertain significance Single submitter
- LTB4R2 p.Pro254Thr Uncertain significance Single submitter
- LTB4R2 p.Pro36Leu Uncertain significance Single submitter
- LTB4R2 p.Thr112Ala Uncertain significance Single submitter
- LTB4R2 p.Thr24Arg Uncertain significance Single submitter
- LTB4R2 p.Thr59Lys Uncertain significance Single submitter
- LTB4R2 p.Thr83Ile Uncertain significance Single submitter
- LTB4R2 p.Trp48Arg Uncertain significance Single submitter
- LTB4R2 p.Tyr98Cys Uncertain significance Single submitter
- LTB4R2 p.Val203Met Uncertain significance Single submitter
- LTB4R2 p.Val283Phe Uncertain significance Single submitter
All LTB4R2 variants
Benign 2
- p.Thr188= Multiple submitters
- p.Leu187fs Single submitter
Uncertain significance 77
- p.Ala102Thr Single submitter ⚠
- p.Ala129Ser Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Ala157Val Single submitter ⚠
- p.Ala178Thr Single submitter ⚠
- p.Ala189Val Single submitter ⚠
- p.Ala265Thr Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala57Val Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala70Thr Single submitter ⚠
- p.Ala70Val Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg131Trp Single submitter ⚠
- p.Arg20Trp Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Arg340His Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg52Pro Single submitter ⚠
- p.Asn342Ser Single submitter ⚠
- p.Asp294Asn Single submitter ⚠
- p.Cys4Tyr Single submitter ⚠
- p.Glu185Gln Single submitter ⚠
- p.Gly113Ala Single submitter ⚠
- p.Gly113Cys Single submitter ⚠
- p.Gly199Ser Single submitter ⚠
- p.Gly214Cys Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly257Glu Single submitter ⚠
- p.Gly316Arg Single submitter ⚠
- p.Gly318Asp Single submitter ⚠
- p.Gly353Arg Single submitter ⚠
- p.His181Leu Single submitter ⚠
- p.Leu152Phe Single submitter ⚠
- p.Leu236Arg Single submitter ⚠
- p.Leu236Pro Single submitter ⚠
- p.Leu245Phe Single submitter ⚠
- p.Leu246Gln Single submitter ⚠
- p.Leu246Pro Single submitter ⚠
- p.Leu262Pro Single submitter ⚠
- p.Leu56Pro Single submitter ⚠
- p.Leu89Arg Single submitter ⚠
- p.Met105Leu Single submitter ⚠
- p.Pro126Ser Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro135Ser Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro193Thr Single submitter ⚠
- p.Pro254Ser Single submitter ⚠
- p.Pro254Thr Single submitter ⚠
- p.Pro285Gln Single submitter ⚠
- p.Pro331Arg Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro76Gln Single submitter ⚠
- p.Pro7Ala Single submitter ⚠
- p.Ser215Pro Single submitter ⚠
- p.Ser282Cys Single submitter ⚠
- p.Thr112Ala Single submitter ⚠
- p.Thr186Ser Single submitter ⚠
- p.Thr22Ile Single submitter ⚠
- p.Thr24Arg Single submitter ⚠
- p.Thr59Lys Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Trp146Ser Single submitter ⚠
- p.Trp16Cys Single submitter ⚠
- p.Trp356Arg Single submitter ⚠
- p.Trp48Arg Single submitter ⚠
- p.Tyr98Cys Single submitter ⚠
- p.Val154Leu Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val283Phe Single submitter ⚠
- p.Val41Leu Single submitter ⚠
- p.Val42Ala Single submitter ⚠