LTC4S — 19 ClinVar variants
All ClinVar germline LTC4S variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Benign · 1 Likely benign · 17 Uncertain significance
Full LTC4S gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LTC4S p.Ala106Thr Uncertain significance Single submitter
- LTC4S p.Ala10Val Uncertain significance Single submitter
- LTC4S p.Ala114Val Uncertain significance Single submitter
- LTC4S p.Arg31Lys Uncertain significance Single submitter
- LTC4S p.Cys56Arg Uncertain significance Single submitter
- LTC4S p.Leu108Met Uncertain significance Single submitter
- LTC4S p.Leu131Phe Uncertain significance Single submitter
- LTC4S p.Leu87Pro Uncertain significance Single submitter
- LTC4S p.Leu91Arg Uncertain significance Single submitter
- LTC4S p.Leu91Phe Uncertain significance Single submitter
- LTC4S p.Pro61Thr Uncertain significance Single submitter
- LTC4S p.Thr12Pro Uncertain significance Single submitter
All LTC4S variants
Benign 1
- p.Leu8= Single submitter
Likely benign 1
- c.229+7G>A Single submitter
Uncertain significance 17
- c.158+4A>C Single submitter hypotonia-failure to thrive-microcephaly syndrome
- c.229+1G>A Single submitter asthma, nasal polyps, and aspirin intolerance
- p.Ala106Thr Single submitter ⚠
- p.Ala10Val Single submitter ⚠
- p.Ala114Val Single submitter ⚠
- p.Arg31Lys Single submitter ⚠
- p.Cys56Arg Single submitter ⚠
- p.Leu108Met Single submitter ⚠
- p.Leu127His Single submitter
- p.Leu131Phe Single submitter ⚠
- p.Leu87Pro Single submitter ⚠
- p.Leu91Arg Single submitter ⚠
- p.Leu91Phe Single submitter ⚠
- p.Pro107Ser Single submitter
- p.Pro44His Single submitter
- p.Pro61Thr Single submitter ⚠
- p.Thr12Pro Single submitter ⚠