LY6K — 39 ClinVar variants
All ClinVar germline LY6K variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
5 Likely benign · 34 Uncertain significance
Full LY6K gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LY6K p.Ala19Ser Uncertain significance Single submitter
- LY6K p.Ala2Ser Uncertain significance Single submitter
- LY6K p.Ala2Val Uncertain significance Single submitter
- LY6K p.Ala87Thr Uncertain significance Single submitter
- LY6K p.Arg101Trp Uncertain significance Single submitter
- LY6K p.Arg119His Uncertain significance Single submitter
- LY6K p.Arg58Ser Uncertain significance Single submitter
- LY6K p.Arg94Lys Uncertain significance Single submitter
- LY6K p.Asp38Glu Uncertain significance Single submitter
- LY6K p.Cys116Arg Uncertain significance Single submitter
- LY6K p.Glu99Lys Uncertain significance Single submitter
- LY6K p.Gly161Ser Uncertain significance Single submitter
- LY6K p.Gly37Ala Uncertain significance Single submitter
- LY6K p.Ile158Met Uncertain significance Single submitter
- LY6K p.Ile74Val Uncertain significance Single submitter
- LY6K p.Leu103Pro Uncertain significance Single submitter
- LY6K p.Leu164Pro Uncertain significance Single submitter
- LY6K p.Leu21Val Uncertain significance Single submitter
- LY6K p.Pro127Arg Uncertain significance Single submitter
- LY6K p.Ser143Asn Uncertain significance Single submitter
- LY6K p.Trp148Arg Uncertain significance Single submitter
- LY6K p.Trp16Arg Uncertain significance Single submitter
- LY6K p.Trp62Arg Uncertain significance Single submitter
- LY6K p.Val15Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- LY6K p.Ala5Pro Uncertain significance Single submitter
- LY6K p.Arg77Cys Uncertain significance Single submitter
- LY6K p.Asn122Ser Uncertain significance Single submitter
- LY6K p.Phe110Leu Uncertain significance Single submitter
- LY6K p.Phe52Ser Uncertain significance Single submitter
- LY6K p.Phe78Leu Uncertain significance Single submitter
- LY6K p.Ser86Cys Uncertain significance Single submitter
- LY6K p.Thr17Lys Uncertain significance Single submitter
- LY6K p.Thr51Ile Uncertain significance Single submitter
- LY6K p.Val72Glu Uncertain significance Single submitter
All LY6K variants
Likely benign 5
Uncertain significance 34
- p.Ala19Ser Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala5Pro Single submitter ⚠
- p.Ala87Thr Single submitter ⚠
- p.Arg101Trp Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg58Ser Single submitter ⚠
- p.Arg77Cys Single submitter ⚠
- p.Arg94Lys Single submitter ⚠
- p.Asn122Ser Single submitter ⚠
- p.Asp38Glu Single submitter ⚠
- p.Cys116Arg Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Gly161Ser Single submitter ⚠
- p.Gly37Ala Single submitter ⚠
- p.Ile158Met Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Leu103Pro Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu21Val Single submitter ⚠
- p.Phe110Leu Single submitter ⚠
- p.Phe52Ser Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Pro127Arg Single submitter ⚠
- p.Ser143Asn Single submitter ⚠
- p.Ser86Cys Single submitter ⚠
- p.Thr17Lys Single submitter ⚠
- p.Thr51Ile Single submitter ⚠
- p.Trp148Arg Single submitter ⚠
- p.Trp16Arg Single submitter ⚠
- p.Trp62Arg Single submitter ⚠
- p.Val15Leu Single submitter ⚠
- p.Val72Glu Single submitter ⚠