LY75-CD302 — 7 ClinVar variants
All ClinVar germline LY75-CD302 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
7 Uncertain significance
Full LY75-CD302 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LY75-CD302 p.Ala243Val Uncertain significance Single submitter
- LY75-CD302 p.Arg2Ser Uncertain significance Single submitter
- LY75-CD302 p.Gly207Ser Uncertain significance Single submitter
- LY75-CD302 p.Pro642Leu Uncertain significance Single submitter
- LY75-CD302 p.Pro957Ser Uncertain significance Single submitter
- LY75-CD302 p.Val92Gly Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All LY75-CD302 variants
Uncertain significance 7
- p.Ala243Val Single submitter ⚠
- p.Arg2Ser Single submitter ⚠
- p.Gly207Ser Single submitter ⚠
- p.Pro642Leu Single submitter ⚠
- p.Pro957Ser Single submitter ⚠
- p.Ser1840Pro Single submitter ⚠
- p.Val92Gly Single submitter ⚠