LY96 — 12 ClinVar variants
All ClinVar germline LY96 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Likely benign · 10 Uncertain significance
Full LY96 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LY96 p.Asn77His Uncertain significance Single submitter
- LY96 p.Gly110Arg Uncertain significance Single submitter
- LY96 p.Ile117Met Uncertain significance Single submitter
- LY96 p.Ile46Val Uncertain significance Single submitter
- LY96 p.Pro157Leu Uncertain significance Single submitter
- LY96 p.Thr84Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All LY96 variants
Likely benign 2
- p.Asn83Lys Single submitter
- p.Leu71Ile Single submitter
Uncertain significance 10
- p.Ala137Thr Single submitter ⚠
- p.Asn77His Single submitter ⚠
- p.Gly110Arg Single submitter ⚠
- p.Ile117Met Single submitter ⚠
- p.Ile46Val Single submitter ⚠
- p.Phe76Leu Single submitter ⚠
- p.Pro157Leu Single submitter ⚠
- p.Thr84Ile Single submitter ⚠
- p.Tyr36Cys Single submitter
- p.Tyr42Cys Single submitter ⚠