LYAR — 65 ClinVar variants
All ClinVar germline LYAR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
2 Likely benign · 63 Uncertain significance
Full LYAR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LYAR p.Ser276Leu Uncertain significance Multiple submitters
- LYAR p.Ala259Thr Uncertain significance Single submitter
- LYAR p.Ala303Pro Uncertain significance Single submitter
- LYAR p.Arg109Gly Uncertain significance Single submitter
- LYAR p.Arg153Trp Uncertain significance Single submitter
- LYAR p.Arg265Cys Uncertain significance Single submitter
- LYAR p.Asn106Lys Uncertain significance Single submitter
- LYAR p.Asn126Tyr Uncertain significance Single submitter
- LYAR p.Asn242Ile Uncertain significance Single submitter
- LYAR p.Asn242Ser Uncertain significance Single submitter
- LYAR p.Asn310Ser Uncertain significance Single submitter
- LYAR p.Asn89Tyr Uncertain significance Single submitter
- LYAR p.Asp131Val Uncertain significance Single submitter
- LYAR p.Asp176Glu Uncertain significance Single submitter
- LYAR p.Asp301Asn Uncertain significance Single submitter
- LYAR p.Gln132Arg Uncertain significance Single submitter
- LYAR p.Gln196Arg Uncertain significance Single submitter
- LYAR p.Gln212Arg Uncertain significance Single submitter
- LYAR p.Gln254Arg Uncertain significance Single submitter
- LYAR p.Glu11Gly Uncertain significance Single submitter
- LYAR p.Glu19Asp Uncertain significance Single submitter
- LYAR p.Glu237Gly Uncertain significance Single submitter
- LYAR p.Glu294Gln Uncertain significance Single submitter
- LYAR p.Glu299Gly Uncertain significance Single submitter
- LYAR p.Glu346Lys Uncertain significance Single submitter
- LYAR p.Glu351Lys Uncertain significance Single submitter
- LYAR p.Glu99Asp Uncertain significance Single submitter
- LYAR p.Gly313Ala Uncertain significance Single submitter
- LYAR p.Gly70Arg Uncertain significance Single submitter
- LYAR p.His162Leu Uncertain significance Single submitter
- LYAR p.His21Arg Uncertain significance Single submitter
- LYAR p.His292Tyr Uncertain significance Single submitter
- LYAR p.Ile129Phe Uncertain significance Single submitter
- LYAR p.Ile52Val Uncertain significance Single submitter
- LYAR p.Leu371Phe Uncertain significance Single submitter
- LYAR p.Lys203Asn Uncertain significance Single submitter
- LYAR p.Lys207Gln Uncertain significance Single submitter
- LYAR p.Lys253Gln Uncertain significance Single submitter
- LYAR p.Lys364Arg Uncertain significance Single submitter
- LYAR p.Lys50Gln Uncertain significance Single submitter
- LYAR p.Pro145Thr Uncertain significance Single submitter
- LYAR p.Pro154Gln Uncertain significance Single submitter
- LYAR p.Pro293Arg Uncertain significance Single submitter
- LYAR p.Pro304Ser Uncertain significance Single submitter
- LYAR p.Pro323Ser Uncertain significance Single submitter
- LYAR p.Pro366Arg Uncertain significance Single submitter
- LYAR p.Ser128Pro Uncertain significance Single submitter
- LYAR p.Ser141Phe Uncertain significance Single submitter
- LYAR p.Tyr45Cys Uncertain significance Single submitter
- LYAR p.Val124Leu Uncertain significance Single submitter
- LYAR p.Val146Ile Uncertain significance Single submitter
- LYAR p.Val146Phe Uncertain significance Single submitter
- LYAR p.Val184Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- LYAR p.Arg255Cys Uncertain significance Single submitter
- LYAR p.Asp105Val Uncertain significance Single submitter
- LYAR p.Asp43His Uncertain significance Single submitter
- LYAR p.Glu29Gln Uncertain significance Single submitter
- LYAR p.Gly65Asp Uncertain significance Single submitter
- LYAR p.Lys188Ile Uncertain significance Single submitter
- LYAR p.Lys69Asn Uncertain significance Single submitter
- LYAR p.Phe368Cys Uncertain significance Single submitter
- LYAR p.Thr342Pro Uncertain significance Single submitter
- LYAR p.Tyr58Phe Uncertain significance Single submitter
All LYAR variants
Likely benign 2
- p.Ala177Thr Single submitter
- p.Asp131Glu Single submitter
Uncertain significance 63
- p.Ser276Leu Multiple submitters ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala303Pro Single submitter ⚠
- p.Arg109Gly Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Asn106Lys Single submitter ⚠
- p.Asn126Tyr Single submitter ⚠
- p.Asn242Ile Single submitter ⚠
- p.Asn242Ser Single submitter ⚠
- p.Asn310Ser Single submitter ⚠
- p.Asn89Tyr Single submitter ⚠
- p.Asp105Val Single submitter ⚠
- p.Asp131Val Single submitter ⚠
- p.Asp176Glu Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp43His Single submitter ⚠
- p.Gln132Arg Single submitter ⚠
- p.Gln196Arg Single submitter ⚠
- p.Gln212Arg Single submitter ⚠
- p.Gln254Arg Single submitter ⚠
- p.Glu11Gly Single submitter ⚠
- p.Glu19Asp Single submitter ⚠
- p.Glu237Gly Single submitter ⚠
- p.Glu294Gln Single submitter ⚠
- p.Glu299Gly Single submitter ⚠
- p.Glu29Gln Single submitter ⚠
- p.Glu346Lys Single submitter ⚠
- p.Glu351Lys Single submitter ⚠
- p.Glu99Asp Single submitter ⚠
- p.Gly313Ala Single submitter ⚠
- p.Gly65Asp Single submitter ⚠
- p.Gly70Arg Single submitter ⚠
- p.His162Leu Single submitter ⚠
- p.His21Arg Single submitter ⚠
- p.His292Tyr Single submitter ⚠
- p.Ile129Phe Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu371Phe Single submitter ⚠
- p.Lys188Ile Single submitter ⚠
- p.Lys203Asn Single submitter ⚠
- p.Lys207Gln Single submitter ⚠
- p.Lys253Gln Single submitter ⚠
- p.Lys364Arg Single submitter ⚠
- p.Lys50Gln Single submitter ⚠
- p.Lys69Asn Single submitter ⚠
- p.Phe368Cys Single submitter ⚠
- p.Pro145Thr Single submitter ⚠
- p.Pro154Gln Single submitter ⚠
- p.Pro293Arg Single submitter ⚠
- p.Pro304Ser Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro366Arg Single submitter ⚠
- p.Ser128Pro Single submitter ⚠
- p.Ser141Phe Single submitter ⚠
- p.Thr342Pro Single submitter ⚠
- p.Tyr45Cys Single submitter ⚠
- p.Tyr58Phe Single submitter ⚠
- p.Val124Leu Single submitter ⚠
- p.Val146Ile Single submitter ⚠
- p.Val146Phe Single submitter ⚠
- p.Val184Leu Single submitter ⚠