Sugi Variant

Sugi Variant/LYN

LYN — 298 ClinVar variants

All ClinVar germline LYN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →

4 Pathogenic · 2 Conflicting · 10 Benign · 2 Benign/Likely benign · 154 Likely benign · 126 Uncertain significance

Full LYN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 104

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 78

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 25

The independent predictors disagree with each other — read with care.

All LYN variants

Pathogenic 4

  • p.Gln507Ter No assertion criteria autoinflammatory disease, systemic, with vasculitis
  • p.Tyr508His No assertion criteria autoinflammatory disease, systemic, with vasculitis ⚠
  • p.Tyr508Phe No assertion criteria autoinflammatory disease, systemic, with vasculitis ⚠
  • p.Tyr508Ter No assertion criteria autoinflammatory disease, systemic, with vasculitis

Conflicting classifications of pathogenicity 2

Benign 10

Benign/Likely benign 2

Likely benign 154

Uncertain significance 126