LYPLA1 — 19 ClinVar variants
All ClinVar germline LYPLA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
1 Benign · 2 Likely benign · 16 Uncertain significance
Full LYPLA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LYPLA1 p.Gln168His Uncertain significance Single submitter
- LYPLA1 p.Glu103Val Uncertain significance Single submitter
- LYPLA1 p.His170Leu Uncertain significance Single submitter
- LYPLA1 p.Ile108Val Uncertain significance Single submitter
- LYPLA1 p.Ile49Val Uncertain significance Single submitter
- LYPLA1 p.Lys201Asn Uncertain significance Single submitter
- LYPLA1 p.Met206Thr Uncertain significance Single submitter
- LYPLA1 p.Pro54Leu Uncertain significance Single submitter
- LYPLA1 p.Thr33Ile Uncertain significance Single submitter
- LYPLA1 p.Tyr127Phe Uncertain significance Single submitter
- LYPLA1 p.Val177Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All LYPLA1 variants
Benign 1
- p.Pro153Ser Multiple submitters
Likely benign 2
- p.Gly158Ser Single submitter
- p.His170= Single submitter
Uncertain significance 16
- p.Ala141Gly Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Gln168His Single submitter ⚠
- p.Glu103Val Single submitter ⚠
- p.His170Leu Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile49Thr Single submitter ⚠
- p.Ile49Val Single submitter ⚠
- p.Lys201Asn Single submitter ⚠
- p.Met206Thr Single submitter ⚠
- p.Pro195Ala Single submitter ⚠
- p.Pro54Leu Single submitter ⚠
- p.Ser209Cys Single submitter ⚠
- p.Thr33Ile Single submitter ⚠
- p.Tyr127Phe Single submitter ⚠
- p.Val177Ile Single submitter ⚠