LYPLA2 — 25 ClinVar variants
All ClinVar germline LYPLA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
25 Uncertain significance
Full LYPLA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LYPLA2 p.Ala101Thr Uncertain significance Single submitter
- LYPLA2 p.Ala185Thr Uncertain significance Single submitter
- LYPLA2 p.Ala43Thr Uncertain significance Single submitter
- LYPLA2 p.Ala59Thr Uncertain significance Single submitter
- LYPLA2 p.Ala95Thr Uncertain significance Single submitter
- LYPLA2 p.Arg48Gln Uncertain significance Single submitter
- LYPLA2 p.Asp165Asn Uncertain significance Single submitter
- LYPLA2 p.Glu21Gln Uncertain significance Single submitter
- LYPLA2 p.Glu225Ala Uncertain significance Single submitter
- LYPLA2 p.Leu78Val Uncertain significance Single submitter
- LYPLA2 p.Lys94Thr Uncertain significance Single submitter
- LYPLA2 p.Met209Thr Uncertain significance Single submitter
- LYPLA2 p.Thr196Ile Uncertain significance Single submitter
- LYPLA2 p.Val17Gly Uncertain significance Single submitter
- LYPLA2 p.Val52Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- LYPLA2 p.Ala113Thr Uncertain significance Single submitter
- LYPLA2 p.Ala188Pro Uncertain significance Single submitter
- LYPLA2 p.Arg153Trp Uncertain significance Single submitter
- LYPLA2 p.Arg48Trp Uncertain significance Single submitter
- LYPLA2 p.Asp42His Uncertain significance Single submitter
- LYPLA2 p.Met217Ile Uncertain significance Single submitter
- LYPLA2 p.Pro206Ala Uncertain significance Single submitter
- LYPLA2 p.Val220Met Uncertain significance Single submitter
All LYPLA2 variants
Uncertain significance 25
- p.Ala101Thr Single submitter ⚠
- p.Ala113Thr Single submitter ⚠
- p.Ala185Thr Single submitter ⚠
- p.Ala188Pro Single submitter ⚠
- p.Ala43Thr Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Ala95Thr Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg22Trp Single submitter
- p.Arg48Gln Single submitter ⚠
- p.Arg48Trp Single submitter ⚠
- p.Asp165Asn Single submitter ⚠
- p.Asp42His Single submitter ⚠
- p.Glu21Gln Single submitter ⚠
- p.Glu225Ala Single submitter ⚠
- p.Glu89Lys Single submitter
- p.Leu78Val Single submitter ⚠
- p.Lys94Thr Single submitter ⚠
- p.Met209Thr Single submitter ⚠
- p.Met217Ile Single submitter ⚠
- p.Pro206Ala Single submitter ⚠
- p.Thr196Ile Single submitter ⚠
- p.Val17Gly Single submitter ⚠
- p.Val220Met Single submitter ⚠
- p.Val52Ile Single submitter ⚠