LYPLAL1 — 39 ClinVar variants
All ClinVar germline LYPLAL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Benign · 3 Likely benign · 35 Uncertain significance
Full LYPLAL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LYPLAL1 p.Asn75Ser Uncertain significance Single submitter
- LYPLAL1 p.Asn85Ser Uncertain significance Single submitter
- LYPLAL1 p.Asp103Gly Uncertain significance Single submitter
- LYPLAL1 p.Asp106Glu Uncertain significance Single submitter
- LYPLAL1 p.Asp179Gly Uncertain significance Single submitter
- LYPLAL1 p.Gln162His Uncertain significance Single submitter
- LYPLAL1 p.Gly143Glu Uncertain significance Single submitter
- LYPLAL1 p.Gly176Asp Uncertain significance Single submitter
- LYPLAL1 p.Gly6Ala Uncertain significance Single submitter
- LYPLAL1 p.His175Arg Uncertain significance Single submitter
- LYPLAL1 p.Ile220Val Uncertain significance Single submitter
- LYPLAL1 p.Ile225Val Uncertain significance Single submitter
- LYPLAL1 p.Ile54Met Uncertain significance Single submitter
- LYPLAL1 p.Ile54Val Uncertain significance Single submitter
- LYPLAL1 p.Leu181Ser Uncertain significance Single submitter
- LYPLAL1 p.Leu45Phe Uncertain significance Single submitter
- LYPLAL1 p.Leu91Val Uncertain significance Single submitter
- LYPLAL1 p.Met125Val Uncertain significance Single submitter
- LYPLAL1 p.Met129Thr Uncertain significance Single submitter
- LYPLAL1 p.Met193Arg Uncertain significance Single submitter
- LYPLAL1 p.Met193Ile Uncertain significance Single submitter
- LYPLAL1 p.Met97Thr Uncertain significance Single submitter
- LYPLAL1 p.Ser148Cys Uncertain significance Single submitter
- LYPLAL1 p.Thr50Ile Uncertain significance Single submitter
- LYPLAL1 p.Thr84Asn Uncertain significance Single submitter
- LYPLAL1 p.Val100Ala Uncertain significance Single submitter
- LYPLAL1 p.Val182Ala Uncertain significance Single submitter
- LYPLAL1 p.Val76Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All LYPLAL1 variants
Benign 1
- p.Leu197Val Multiple submitters
Likely benign 3
- p.Ala154Thr Single submitter
- p.Asn165Asp Single submitter
- p.Ser164Asn Single submitter
Uncertain significance 35
- p.Asn75Ser Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asp103Gly Single submitter ⚠
- p.Asp106Glu Single submitter ⚠
- p.Asp179Gly Single submitter ⚠
- p.Gln162His Single submitter ⚠
- p.Gly143Glu Single submitter ⚠
- p.Gly176Asp Single submitter ⚠
- p.Gly6Ala Single submitter ⚠
- p.His175Arg Single submitter ⚠
- p.Ile118Val Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Ile225Val Single submitter ⚠
- p.Ile54Met Single submitter ⚠
- p.Ile54Val Single submitter ⚠
- p.Leu161Phe Single submitter ⚠
- p.Leu181Ser Single submitter ⚠
- p.Leu45Phe Single submitter ⚠
- p.Leu91Val Single submitter ⚠
- p.Lys42Glu Single submitter ⚠
- p.Met125Val Single submitter ⚠
- p.Met129Thr Single submitter ⚠
- p.Met193Arg Single submitter ⚠
- p.Met193Ile Single submitter ⚠
- p.Met97Thr Single submitter ⚠
- p.Phe145Val Single submitter
- p.Pro230Leu Single submitter
- p.Pro68Leu Single submitter
- p.Ser148Cys Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Thr84Asn Single submitter ⚠
- p.Tyr135Cys Single submitter ⚠
- p.Val100Ala Single submitter ⚠
- p.Val182Ala Single submitter ⚠
- p.Val76Ile Single submitter ⚠