Sugi Variant

Sugi Variant/MAGED2

MAGED2 — 182 ClinVar variants

All ClinVar germline MAGED2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →

10 Pathogenic · 10 Likely pathogenic · 5 Conflicting · 38 Benign · 5 Benign/Likely benign · 35 Likely benign · 79 Uncertain significance

Full MAGED2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 66

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 55

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 7

The independent predictors disagree with each other — read with care.

All MAGED2 variants

Pathogenic 10

Likely pathogenic 10

Conflicting classifications of pathogenicity 5

Benign 38

Benign/Likely benign 5

Likely benign 35

Uncertain significance 79