Sugi Variant

Sugi Variant/MAGI2

MAGI2 — 652 ClinVar variants

All ClinVar germline MAGI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 322 flagged for review →

4 Pathogenic · 8 Likely pathogenic · 19 Conflicting · 86 Benign · 12 Benign/Likely benign · 159 Likely benign · 364 Uncertain significance

Full MAGI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 322

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 256

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 256

Predictors split 58

The independent predictors disagree with each other — read with care.

All MAGI2 variants

Pathogenic 4

Likely pathogenic 8

Conflicting classifications of pathogenicity 19

Benign 86

Benign/Likely benign 12

Likely benign 159

Uncertain significance 364

Showing the top 300 by review status; the full set is in the sitemap.