MAGI3 — 153 ClinVar variants

All ClinVar germline MAGI3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →

2 Benign · 5 Likely benign · 146 Uncertain significance

Full MAGI3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 140

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 120

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 20

The independent predictors disagree with each other — read with care.

All MAGI3 variants

Benign 2

p.Gly1321= Multiple submitters
p.Thr223= Multiple submitters

Likely benign 5

p.Arg768His Single submitter
p.Gln1278His Single submitter
p.Met536Val Single submitter
p.Thr1441Ser Single submitter
p.Val1145Met Single submitter

Uncertain significance 146

p.Ala1287Pro Single submitter ⚠
p.Ala1477Thr Single submitter ⚠
p.Ala149Ser Single submitter ⚠
p.Ala170Ser Single submitter ⚠
p.Ala247Pro Single submitter ⚠
p.Ala374Gly Single submitter ⚠
p.Ala64Val Single submitter ⚠
p.Ala664Val Single submitter ⚠
p.Ala754Thr Single submitter ⚠
p.Ala770Ser Single submitter ⚠
p.Ala796Ser Single submitter ⚠
p.Ala926Gly Single submitter
p.Arg1029Gln Single submitter ⚠
p.Arg1029Trp Single submitter ⚠
p.Arg114Gln Single submitter
p.Arg114Trp Single submitter ⚠
p.Arg1480Gln Single submitter ⚠
p.Arg410Gln Single submitter ⚠
p.Arg47Gln Single submitter ⚠
p.Arg47Trp Single submitter ⚠
p.Arg730Gln Single submitter ⚠
p.Arg766Gln Single submitter
p.Arg766Pro Single submitter ⚠
p.Arg768Cys Single submitter
p.Arg798Gln Single submitter ⚠
p.Arg837Trp Single submitter ⚠
p.Arg884Gln Single submitter ⚠
p.Arg92Leu Single submitter ⚠
p.Asn1093Ser Single submitter ⚠
p.Asn1207Thr Single submitter ⚠
p.Asn256Ser Single submitter ⚠
p.Asn626Ser Single submitter ⚠
p.Asn967Ser Single submitter ⚠
p.Asp1335Asn Single submitter ⚠
p.Asp1398Asn Single submitter ⚠
p.Asp206Glu Single submitter ⚠
p.Asp281Val Single submitter ⚠
p.Asp338Asn Single submitter ⚠
p.Asp530Tyr Single submitter ⚠
p.Asp669Glu Single submitter ⚠
p.Asp820Asn Single submitter ⚠
p.Cys1157Arg Single submitter ⚠
p.Cys1266Tyr Single submitter ⚠
p.Cys1279Arg Single submitter ⚠
p.Cys491Tyr Single submitter ⚠
p.Gln1293Arg Single submitter ⚠
p.Gln447Glu Single submitter ⚠
p.Gln475His Single submitter ⚠
p.Gln641Arg Single submitter ⚠
p.Gln855His Single submitter arthrogryposis multiplex congenita ⚠
p.Glu1149Lys Single submitter ⚠
p.Glu1169Gln Single submitter ⚠
p.Glu1176Asp Single submitter ⚠
p.Glu1233Gln Single submitter ⚠
p.Glu1310Ala Single submitter ⚠
p.Glu1347Lys Single submitter ⚠
p.Glu1383Val Single submitter ⚠
p.Glu1447Gln Single submitter ⚠
p.Glu337Ala Single submitter ⚠
p.Glu51Val Single submitter ⚠
p.Glu682Gln Single submitter ⚠
p.Glu682Gly Single submitter ⚠
p.Glu848Lys Single submitter ⚠
p.Gly1037Glu Single submitter ⚠
p.Gly1091Asp Single submitter ⚠
p.Gly1311Val Single submitter ⚠
p.Gly1472Arg Single submitter ⚠
p.Gly27Val Single submitter ⚠
p.Gly406Ser Single submitter ⚠
p.Gly467Ala Single submitter ⚠
p.Gly493Asp Single submitter ⚠
p.Gly534Arg Single submitter ⚠
p.Gly54Arg Single submitter ⚠
p.Gly550Arg Single submitter ⚠
p.Gly698Arg Single submitter ⚠
p.Gly742Arg Single submitter ⚠
p.Gly783Glu Single submitter ⚠
p.His1109Tyr Single submitter ⚠
p.His1144Leu Single submitter ⚠
p.His1183Asn Single submitter ⚠
p.His1202Gln Single submitter ⚠
p.His940Leu Single submitter ⚠
p.Ile126Val Single submitter ⚠
p.Ile1457Val Single submitter ⚠
p.Ile460Met Single submitter ⚠
p.Ile592Val Single submitter ⚠
p.Ile694Val Single submitter ⚠
p.Ile755Val Single submitter ⚠
p.Ile776Val Single submitter ⚠
p.Leu48Phe Single submitter ⚠
p.Leu490Val Single submitter ⚠
p.Leu714Ser Single submitter ⚠
p.Lys1264Thr Single submitter ⚠
p.Lys1312Arg Single submitter ⚠
p.Lys1399Asn Single submitter ⚠
p.Lys1428Arg Single submitter ⚠
p.Lys1430Arg Single submitter ⚠
p.Lys297Gln Single submitter ⚠
p.Lys662Glu Single submitter ⚠
p.Lys718Asn Single submitter ⚠
p.Lys996Asn Single submitter ⚠
p.Met280Val Single submitter ⚠
p.Met308Leu Single submitter
p.Met418Val Single submitter ⚠
p.Met688Val Single submitter ⚠
p.Phe642Leu Single submitter ⚠
p.Pro1131Ser Single submitter ⚠
p.Pro1168Ala Single submitter ⚠
p.Pro1196Leu Single submitter ⚠
p.Pro657Leu Single submitter ⚠
p.Pro692Gln Single submitter ⚠
p.Pro692Leu Single submitter ⚠
p.Pro873Leu Single submitter ⚠
p.Pro875Leu Single submitter ⚠
p.Pro944Leu Single submitter ⚠
p.Ser1151Thr Single submitter ⚠
p.Ser1172Cys Single submitter ⚠
p.Ser1221Leu Single submitter ⚠
p.Ser1286Leu Single submitter ⚠
p.Ser1313Asn Single submitter ⚠
p.Ser1394Asn Single submitter ⚠
p.Ser1394Ile Single submitter ⚠
p.Ser235Cys Single submitter ⚠
p.Ser278Asn Single submitter ⚠
p.Ser544Leu Single submitter ⚠
p.Ser61Trp Single submitter ⚠
p.Ser749Phe Single submitter
p.Ser80Thr Single submitter ⚠
p.Ser904Phe Single submitter ⚠
p.Ser991Ala Single submitter ⚠
p.Thr1320Met Single submitter ⚠
p.Thr147Ala Single submitter ⚠
p.Thr417Ile Single submitter ⚠
p.Thr56Ser Single submitter ⚠
p.Thr828Ile Single submitter ⚠
p.Thr87Ala Single submitter ⚠
p.Thr933Met Single submitter ⚠
p.Tyr303Cys Single submitter ⚠
p.Tyr812Cys Single submitter ⚠
p.Val1191Ala Single submitter ⚠
p.Val1336Ala Single submitter ⚠
p.Val1336Ile Single submitter ⚠
p.Val205Leu Single submitter ⚠
p.Val504Ile Single submitter ⚠
p.Val638Met Single submitter ⚠
p.Val885Ile Single submitter ⚠