MAL2 — 11 ClinVar variants
All ClinVar germline MAL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
11 Uncertain significance
Full MAL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAL2 p.Ala15Thr Uncertain significance Single submitter
- MAL2 p.Asn147Ser Uncertain significance Single submitter
- MAL2 p.Gly4Asp Uncertain significance Single submitter
- MAL2 p.Gly4Ser Uncertain significance Single submitter
- MAL2 p.Gly4Val Uncertain significance Single submitter
- MAL2 p.Gly84Ala Uncertain significance Single submitter
- MAL2 p.Phe77Ser Uncertain significance Single submitter
- MAL2 p.Pro19Leu Uncertain significance Single submitter
- MAL2 p.Tyr163Asn Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All MAL2 variants
Uncertain significance 11
- p.Ala15Thr Single submitter ⚠
- p.Asn13Lys Single submitter
- p.Asn147Ser Single submitter ⚠
- p.Gly4Asp Single submitter ⚠
- p.Gly4Ser Single submitter ⚠
- p.Gly4Val Single submitter ⚠
- p.Gly84Ala Single submitter ⚠
- p.Leu119Ser Single submitter ⚠
- p.Phe77Ser Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Tyr163Asn Single submitter ⚠