Sugi Variant

Sugi Variant/MANBA

MANBA — 814 ClinVar variants

All ClinVar germline MANBA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 221 flagged for review →

59 Pathogenic · 12 Pathogenic/Likely pathogenic · 34 Likely pathogenic · 27 Conflicting · 72 Benign · 16 Benign/Likely benign · 353 Likely benign · 241 Uncertain significance

Full MANBA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 221

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 10

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 155

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 155

Predictors split 56

The independent predictors disagree with each other — read with care.

All MANBA variants

Pathogenic 59

Pathogenic/Likely pathogenic 12

Likely pathogenic 34

Conflicting classifications of pathogenicity 27

Benign 72

Benign/Likely benign 16

Likely benign 353

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 241